U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polymyalgia rheumatica

MedGen UID:
19393
Concept ID:
C0032533
Disease or Syndrome
Synonyms: Forestier Certonciny Syndrome; Forestier-Certonciny Syndrome; Peri-Extra-Articular Rheumatism; Polymyalgia Rheumatica; Rheumatism, Peri Extra Articular; Rheumatism, Peri-Extra-Articular; Syndrome, Forestier-Certonciny
SNOMED CT: Polymyalgia rheumatica (65323003); Forestier-Certonciny syndrome (65323003); Senile arthritis (65323003); PMR - Polymyalgia rheumatica (65323003)
 
Monarch Initiative: MONDO:0019735
Orphanet: ORPHA93569

Definition

A rare rheumatologic disease characterized by bilateral morning stiffness which lasts > 45-60 min of duration associated with a subacute-onset of severe pain with active movements, typically affecting the shoulders, proximal upper limbs, neck and/or, less commonly, the pelvic girdle and proximal aspects of thighs, which are exacerbated with inactivity and improve progressively over the day. Muscle tenderness, peripheral synovitis, arthritis, carpal tunnel syndrome or distal tenosynovitis, as well as non-specific symptoms, such as fatigue, asthenia, malaise, low-grade fever, anorexia and weight loss, may be associated. Acute phase reactants (erythrocyte sedimentation rate, C-reactive protein) are increased. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolymyalgia rheumatica

Professional guidelines

PubMed

Ling ML, Yosar J, Lee BW, Shah SA, Jiang IW, Finniss A, Allende A, Francis IC
Clin Exp Optom 2020 Sep;103(5):572-582. Epub 2019 Oct 29 doi: 10.1111/cxo.12975. PMID: 31663193
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250

Recent clinical studies

Etiology

Wendling D
Expert Opin Biol Ther 2023 Jul-Dec;23(12):1255-1263. Epub 2023 Dec 28 doi: 10.1080/14712598.2023.2287097. PMID: 37994867
Espígol-Frigolé G, Dejaco C, Mackie SL, Salvarani C, Matteson EL, Cid MC
Lancet 2023 Oct 21;402(10411):1459-1472. Epub 2023 Oct 10 doi: 10.1016/S0140-6736(23)01310-7. PMID: 37832573
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
Slart RHJA; Writing group; Reviewer group; Members of EANM Cardiovascular; Members of EANM Infection & Inflammation; Members of Committees, SNMMI Cardiovascular; Members of Council, PET Interest Group; Members of ASNC; EANM Committee Coordinator
Eur J Nucl Med Mol Imaging 2018 Jul;45(7):1250-1269. Epub 2018 Apr 11 doi: 10.1007/s00259-018-3973-8. PMID: 29637252Free PMC Article
Buttgereit F, Dejaco C, Matteson EL, Dasgupta B
JAMA 2016 Jun 14;315(22):2442-58. doi: 10.1001/jama.2016.5444. PMID: 27299619

Diagnosis

Rosenberg H, Halman S, Yadav K
CMAJ 2021 Nov 22;193(46):E1770. doi: 10.1503/cmaj.210541. PMID: 34810164Free PMC Article
Mahmood SB, Nelson E, Padniewski J, Nasr R
Cleve Clin J Med 2020 Aug 31;87(9):549-556. doi: 10.3949/ccjm.87a.20008. PMID: 32868305
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
González-Gay MA, Matteson EL, Castañeda S
Lancet 2017 Oct 7;390(10103):1700-1712. Epub 2017 Jul 31 doi: 10.1016/S0140-6736(17)31825-1. PMID: 28774422
Matteson EL, Dejaco C
Ann Intern Med 2017 May 2;166(9):ITC65-ITC80. doi: 10.7326/AITC201705020. PMID: 28460395

Therapy

Espígol-Frigolé G, Dejaco C, Mackie SL, Salvarani C, Matteson EL, Cid MC
Lancet 2023 Oct 21;402(10411):1459-1472. Epub 2023 Oct 10 doi: 10.1016/S0140-6736(23)01310-7. PMID: 37832573
Spiera RF, Unizony S, Warrington KJ, Sloane J, Giannelou A, Nivens MC, Akinlade B, Wong W, Bhore R, Lin Y, Buttgereit F, Devauchelle-Pensec V, Rubbert-Roth A, Yancopoulos GD, Marrache F, Patel N, Dasgupta B; SAPHYR Investigators
N Engl J Med 2023 Oct 5;389(14):1263-1272. doi: 10.1056/NEJMoa2303452. PMID: 37792612
Mahmood SB, Nelson E, Padniewski J, Nasr R
Cleve Clin J Med 2020 Aug 31;87(9):549-556. doi: 10.3949/ccjm.87a.20008. PMID: 32868305
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
González-Gay MA, Matteson EL, Castañeda S
Lancet 2017 Oct 7;390(10103):1700-1712. Epub 2017 Jul 31 doi: 10.1016/S0140-6736(17)31825-1. PMID: 28774422

Prognosis

Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
Rosenberg H, Halman S, Yadav K
CMAJ 2021 Nov 22;193(46):E1770. doi: 10.1503/cmaj.210541. PMID: 34810164Free PMC Article
Camellino D, Giusti A, Girasole G, Bianchi G, Dejaco C
Drugs Aging 2019 Nov;36(11):1015-1026. doi: 10.1007/s40266-019-00705-5. PMID: 31493201
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250
González-Gay MA, Matteson EL, Castañeda S
Lancet 2017 Oct 7;390(10103):1700-1712. Epub 2017 Jul 31 doi: 10.1016/S0140-6736(17)31825-1. PMID: 28774422

Clinical prediction guides

Spiera RF, Unizony S, Warrington KJ, Sloane J, Giannelou A, Nivens MC, Akinlade B, Wong W, Bhore R, Lin Y, Buttgereit F, Devauchelle-Pensec V, Rubbert-Roth A, Yancopoulos GD, Marrache F, Patel N, Dasgupta B; SAPHYR Investigators
N Engl J Med 2023 Oct 5;389(14):1263-1272. doi: 10.1056/NEJMoa2303452. PMID: 37792612
Lundberg IE, Sharma A, Turesson C, Mohammad AJ
J Intern Med 2022 Nov;292(5):717-732. Epub 2022 Jun 11 doi: 10.1111/joim.13525. PMID: 35612524Free PMC Article
Stone JH, McDowell PJ, Jayne DRW, Merkel PA, Robson J, Patel NJ, Zhang Y, Yue H, Bekker P, Heaney LG
Semin Arthritis Rheum 2022 Aug;55:152010. Epub 2022 Apr 15 doi: 10.1016/j.semarthrit.2022.152010. PMID: 35486995
Bonelli M, Radner H, Kerschbaumer A, Mrak D, Durechova M, Stieger J, Husic R, Mandl P, Smolen JS, Dejaco C, Aletaha D
Ann Rheum Dis 2022 Jun;81(6):838-844. Epub 2022 Feb 24 doi: 10.1136/annrheumdis-2021-221126. PMID: 35210264
Sugihara T
Mod Rheumatol 2022 Apr 18;32(3):493-499. doi: 10.1093/mr/roab087. PMID: 34791359

Recent systematic reviews

Kawka L, Chevet B, Arnaud L, Becker G, Carvajal Alegria G, Felten R
Autoimmun Rev 2024 Jul-Aug;23(7-8):103590. Epub 2024 Aug 7 doi: 10.1016/j.autrev.2024.103590. PMID: 39122202
Dejaco C, Kerschbaumer A, Aletaha D, Bond M, Hysa E, Camellino D, Ehlers L, Abril A, Appenzeller S, Cid MC, Dasgupta B, Duftner C, Grayson PC, Hellmich B, Hočevar A, Kermani TA, Matteson EL, Mollan SP, Neill L, Ponte C, Salvarani C, Sattui SE, Schmidt WA, Seo P, Smolen JS, Thiel J, Toro-Gutiérrez CE, Whitlock M, Buttgereit F
Ann Rheum Dis 2024 Jan 2;83(1):48-57. doi: 10.1136/ard-2022-223429. PMID: 36828585Free PMC Article
Chatzigeorgiou C, Mackie SL
Reumatismo 2018 Mar 27;70(1):35-43. doi: 10.4081/reumatismo.2018.1039. PMID: 29589401
Dejaco C, Ramiro S, Duftner C, Besson FL, Bley TA, Blockmans D, Brouwer E, Cimmino MA, Clark E, Dasgupta B, Diamantopoulos AP, Direskeneli H, Iagnocco A, Klink T, Neill L, Ponte C, Salvarani C, Slart RHJA, Whitlock M, Schmidt WA
Ann Rheum Dis 2018 May;77(5):636-643. Epub 2018 Jan 22 doi: 10.1136/annrheumdis-2017-212649. PMID: 29358285
Buttgereit F, Dejaco C, Matteson EL, Dasgupta B
JAMA 2016 Jun 14;315(22):2442-58. doi: 10.1001/jama.2016.5444. PMID: 27299619

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...