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Secondary Parkinson disease

MedGen UID:
10592
•Concept ID:
C0030569
•
Disease or Syndrome
Synonyms: Parkinson Disease, Secondary; Parkinson Disease, Symptomatic; Parkinsonism, Secondary; Parkinsonism, Symptomatic; Secondary Parkinson Disease; Secondary Parkinsonism; Symptomatic Parkinson Disease; Symptomatic Parkinsonism
SNOMED CT: Secondary Parkinson's disease (230292008); Secondary Parkinson disease (230292008); Secondary parkinsonism (230292008); Symptomatic parkinsonism (265377002); Disorders presenting primarily with parkinsonism (32798002)
 
Monarch Initiative: MONDO:0006966

Definition

A condition with a clinical picture similar to that of Parkinson disease, but which is caused by external factors, including medication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Parkinson disease

Professional guidelines

PubMed

Management of Pain in Parkinson's Disease.
Buhmann C, Kassubek J, Jost WH
J Parkinsons Dis 2020;10(s1):S37-S48. doi: 10.3233/JPD-202069. PMID: 32568113Free PMC Article
Autonomic dysfunction: Diagnosis and management.
Rafanelli M, Walsh K, Hamdan MH, Buyan-Dent L
Handb Clin Neurol 2019;167:123-137. doi: 10.1016/B978-0-12-804766-8.00008-X. PMID: 31753129
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS).
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120

Recent clinical studies

Etiology

Drosophila Models of Sporadic Parkinson's Disease.
Nagoshi E
Int J Mol Sci 2018 Oct 26;19(11) doi: 10.3390/ijms19113343. PMID: 30373150Free PMC Article
Secondary parkinsonism.
Terashi H, Taguchi T, Aizawa H
Nihon Rinsho 2017 Jan;75(1):63-70. PMID: 30566296
Molecular imaging of dopamine transporters.
Brooks DJ
Ageing Res Rev 2016 Sep;30:114-21. Epub 2016 Jan 21 doi: 10.1016/j.arr.2015.12.009. PMID: 26802555
Trichloroethylene and Parkinson disease.
Zaheer F, Slevin JT
Neurol Clin 2011 Aug;29(3):657-65. Epub 2011 Jul 7 doi: 10.1016/j.ncl.2011.05.001. PMID: 21803216
Managing antipsychotic-induced parkinsonism.
Mamo DC, Sweet RA, Keshavan MS
Drug Saf 1999 Mar;20(3):269-75. doi: 10.2165/00002018-199920030-00006. PMID: 10221855

Diagnosis

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.
Travagli RA, Browning KN, Camilleri M
Nat Rev Gastroenterol Hepatol 2020 Nov;17(11):673-685. Epub 2020 Jul 31 doi: 10.1038/s41575-020-0339-z. PMID: 32737460
Secondary parkinsonism.
Terashi H, Taguchi T, Aizawa H
Nihon Rinsho 2017 Jan;75(1):63-70. PMID: 30566296
Parkinsonian-Pyramidal syndromes: A systematic review.
Tranchant C, Koob M, Anheim M
Parkinsonism Relat Disord 2017 Jun;39:4-16. Epub 2017 Feb 22 doi: 10.1016/j.parkreldis.2017.02.025. PMID: 28256436
Movement disorders and stroke.
Defebvre L, Krystkowiak P
Rev Neurol (Paris) 2016 Aug-Sep;172(8-9):483-487. Epub 2016 Jul 28 doi: 10.1016/j.neurol.2016.07.006. PMID: 27476417
The diagnosis of Parkinson's disease.
Tolosa E, Wenning G, Poewe W
Lancet Neurol 2006 Jan;5(1):75-86. doi: 10.1016/S1474-4422(05)70285-4. PMID: 16361025

Therapy

Pesticides and Parkinson's disease: Current and future perspective.
Islam MS, Azim F, Saju H, Zargaran A, Shirzad M, Kamal M, Fatema K, Rehman S, Azad MAM, Ebrahimi-Barough S
J Chem Neuroanat 2021 Sep;115:101966. Epub 2021 May 12 doi: 10.1016/j.jchemneu.2021.101966. PMID: 33991619
Agrochemicals, α-synuclein, and Parkinson's disease.
Silva BA, Breydo L, Fink AL, Uversky VN
Mol Neurobiol 2013 Apr;47(2):598-612. Epub 2012 Aug 30 doi: 10.1007/s12035-012-8333-2. PMID: 22933040
Managing antipsychotic-induced parkinsonism.
Mamo DC, Sweet RA, Keshavan MS
Drug Saf 1999 Mar;20(3):269-75. doi: 10.2165/00002018-199920030-00006. PMID: 10221855
Symptomatic Parkinsonism.
Pearce J
Postgrad Med J 1977 Dec;53(626):726-8. doi: 10.1136/pgmj.53.626.726. PMID: 343078Free PMC Article
Parkinsonism--neuropathology.
Lewis PD
Br Med J 1971 Sep 18;3(5776):690-2. doi: 10.1136/bmj.3.5776.690. PMID: 4936440Free PMC Article

Prognosis

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review.
Lappin JM, Darke S
Exp Neurol 2021 Sep;343:113793. Epub 2021 Jun 21 doi: 10.1016/j.expneurol.2021.113793. PMID: 34166684
Parkinsonian-Pyramidal syndromes: A systematic review.
Tranchant C, Koob M, Anheim M
Parkinsonism Relat Disord 2017 Jun;39:4-16. Epub 2017 Feb 22 doi: 10.1016/j.parkreldis.2017.02.025. PMID: 28256436
Movement disorders and stroke.
Defebvre L, Krystkowiak P
Rev Neurol (Paris) 2016 Aug-Sep;172(8-9):483-487. Epub 2016 Jul 28 doi: 10.1016/j.neurol.2016.07.006. PMID: 27476417
The diagnosis of Parkinson's disease.
Tolosa E, Wenning G, Poewe W
Lancet Neurol 2006 Jan;5(1):75-86. doi: 10.1016/S1474-4422(05)70285-4. PMID: 16361025
Metoclopramide-induced parkinsonism.
Sethi KD, Patel B, Meador KJ
South Med J 1989 Dec;82(12):1581-2. doi: 10.1097/00007611-198912000-00033. PMID: 2595431

Clinical prediction guides

Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review.
Lappin JM, Darke S
Exp Neurol 2021 Sep;343:113793. Epub 2021 Jun 21 doi: 10.1016/j.expneurol.2021.113793. PMID: 34166684
Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.
Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF 3rd
Lancet 2015 Dec 12;386(10011):2404-12. Epub 2015 Sep 27 doi: 10.1016/S0140-6736(15)00308-6. PMID: 26423182Free PMC Article
Vascular parkinsonism--characteristics, pathogenesis and treatment.
Korczyn AD
Nat Rev Neurol 2015 Jun;11(6):319-26. Epub 2015 Apr 28 doi: 10.1038/nrneurol.2015.61. PMID: 25917706
Trichloroethylene and Parkinson disease.
Zaheer F, Slevin JT
Neurol Clin 2011 Aug;29(3):657-65. Epub 2011 Jul 7 doi: 10.1016/j.ncl.2011.05.001. PMID: 21803216
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
Langston JW, Ballard P, Tetrud JW, Irwin I
Science 1983 Feb 25;219(4587):979-80. doi: 10.1126/science.6823561. PMID: 6823561

Recent systematic reviews

Metals and neurodegenerative diseases. A systematic review.
Cicero CE, Mostile G, Vasta R, Rapisarda V, Signorelli SS, Ferrante M, Zappia M, Nicoletti A
Environ Res 2017 Nov;159:82-94. Epub 2017 Aug 1 doi: 10.1016/j.envres.2017.07.048. PMID: 28777965
Chlorpromazine versus metiapine for schizophrenia.
Zare M, Bazrafshan A
Cochrane Database Syst Rev 2017 Mar 25;3(3):CD011655. doi: 10.1002/14651858.CD011655.pub2. PMID: 28349512Free PMC Article
Parkinsonian-Pyramidal syndromes: A systematic review.
Tranchant C, Koob M, Anheim M
Parkinsonism Relat Disord 2017 Jun;39:4-16. Epub 2017 Feb 22 doi: 10.1016/j.parkreldis.2017.02.025. PMID: 28256436
Solvents and Parkinson disease: a systematic review of toxicological and epidemiological evidence.
Lock EA, Zhang J, Checkoway H
Toxicol Appl Pharmacol 2013 Feb 1;266(3):345-55. Epub 2012 Dec 7 doi: 10.1016/j.taap.2012.11.016. PMID: 23220449Free PMC Article
Differentiating vascular parkinsonism from idiopathic Parkinson's disease: a systematic review.
Kalra S, Grosset DG, Benamer HT
Mov Disord 2010 Jan 30;25(2):149-56. doi: 10.1002/mds.22937. PMID: 20077476

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