U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sympathetic ophthalmia

MedGen UID:
45203
•Concept ID:
C0029077
•
Disease or Syndrome
Synonyms: Ophthalmia, Sympathetic; Ophthalmias, Sympathetic; Sympathetic Ophthalmia; Sympathetic Ophthalmias; Sympathetic Uveitides; Sympathetic Uveitis; Uveitides, Sympathetic; Uveitis, Sympathetic
SNOMED CT: Sympathetic uveitis (75315001); Sympathetic ophthalmitis (75315001); Sympathetic ophthalmia (75315001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019198
Orphanet: ORPHA79098

Definition

Sympathetic ophthalmia (SO) is a bilateral granulomatous anterior uveitis usually occurring within the three months following trauma or a surgical procedure involving one eye. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSympathetic ophthalmia
Follow this link to review classifications for Sympathetic ophthalmia in Orphanet.

Professional guidelines

PubMed

Sympathetic Ophthalmia: Demographic Characteristics, Clinical Findings, and Treatment Results.
Özdemir Yalçınsoy K, Özdamar Erol Y, Çakar Özdal P
Turk J Ophthalmol 2023 Feb 24;53(1):23-29. doi: 10.4274/tjo.galenos.2022.53383. PMID: 36847630Free PMC Article
Recent advances in diagnosis and management of sympathetic ophthalmia.
Fromal OV, Swaminathan V, Soares RR, Ho AC
Curr Opin Ophthalmol 2021 Nov 1;32(6):555-560. doi: 10.1097/ICU.0000000000000803. PMID: 34494974
Classification Criteria for Sympathetic Ophthalmia.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:212-219. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.048. PMID: 33845005Free PMC Article

Recent clinical studies

Etiology

The Ruptured Globe, Sympathetic Ophthalmia, and the 14-Day Rule.
Jordan DR, J Dutton J
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):315-324. Epub 2022 Sep 28 doi: 10.1097/IOP.0000000000002068. PMID: 34593714
The Incidence of Sympathetic Ophthalmia After Trauma: A Meta-analysis.
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Recent advances in diagnosis and management of sympathetic ophthalmia.
Fromal OV, Swaminathan V, Soares RR, Ho AC
Curr Opin Ophthalmol 2021 Nov 1;32(6):555-560. doi: 10.1097/ICU.0000000000000803. PMID: 34494974
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Sympathetic ophthalmia.
Castiblanco CP, Adelman RA
Graefes Arch Clin Exp Ophthalmol 2009 Mar;247(3):289-302. Epub 2008 Sep 16 doi: 10.1007/s00417-008-0939-8. PMID: 18795315

Diagnosis

Florid sympathetic ophthalmia.
Neerukonda VK, Stagner AM, Wolkow N
Orbit 2024 Aug;43(4):557. Epub 2021 Jul 5 doi: 10.1080/01676830.2021.1939733. PMID: 34219581
Sympathetic ophthalmia: A comprehensive update.
Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Sympathetic Ophthalmia.
Cunningham ET Jr, Kilmartin D, Agarwal M, Zierhut M
Ocul Immunol Inflamm 2017 Apr;25(2):149-151. doi: 10.1080/09273948.2017.1305727. PMID: 28414613
Multimodal Imaging in Sympathetic Ophthalmia.
Mahajan S, Invernizzi A, Agrawal R, Biswas J, Rao NA, Gupta V
Ocul Immunol Inflamm 2017 Apr;25(2):152-159. Epub 2016 Dec 14 doi: 10.1080/09273948.2016.1255339. PMID: 27960610

Therapy

Florid sympathetic ophthalmia.
Neerukonda VK, Stagner AM, Wolkow N
Orbit 2024 Aug;43(4):557. Epub 2021 Jul 5 doi: 10.1080/01676830.2021.1939733. PMID: 34219581
Sympathetic Ophthalmia - An Overview.
Agarwal M, Radosavljevic A, Tyagi M, Pichi F, Al Dhanhani AA, Agarwal A, Cunningham ET Jr
Ocul Immunol Inflamm 2023 May;31(4):793-809. Epub 2022 May 17 doi: 10.1080/09273948.2022.2058554. PMID: 35579612
Sympathetic ophthalmia: A comprehensive update.
Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Multimodal Imaging in Sympathetic Ophthalmia.
Mahajan S, Invernizzi A, Agrawal R, Biswas J, Rao NA, Gupta V
Ocul Immunol Inflamm 2017 Apr;25(2):152-159. Epub 2016 Dec 14 doi: 10.1080/09273948.2016.1255339. PMID: 27960610
Sympathetic ophthalmia.
Chang GC, Young LH
Semin Ophthalmol 2011 Jul-Sep;26(4-5):316-20. doi: 10.3109/08820538.2011.588658. PMID: 21958181

Prognosis

Sympathetic Ophthalmia - An Overview.
Agarwal M, Radosavljevic A, Tyagi M, Pichi F, Al Dhanhani AA, Agarwal A, Cunningham ET Jr
Ocul Immunol Inflamm 2023 May;31(4):793-809. Epub 2022 May 17 doi: 10.1080/09273948.2022.2058554. PMID: 35579612
The Incidence of Sympathetic Ophthalmia After Trauma: A Meta-analysis.
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Recent advances in diagnosis and management of sympathetic ophthalmia.
Fromal OV, Swaminathan V, Soares RR, Ho AC
Curr Opin Ophthalmol 2021 Nov 1;32(6):555-560. doi: 10.1097/ICU.0000000000000803. PMID: 34494974
Intraocular foreign bodies: A review.
Loporchio D, Mukkamala L, Gorukanti K, Zarbin M, Langer P, Bhagat N
Surv Ophthalmol 2016 Sep-Oct;61(5):582-96. Epub 2016 Mar 17 doi: 10.1016/j.survophthal.2016.03.005. PMID: 26994871
Sympathetic ophthalmia.
Castiblanco CP, Adelman RA
Graefes Arch Clin Exp Ophthalmol 2009 Mar;247(3):289-302. Epub 2008 Sep 16 doi: 10.1007/s00417-008-0939-8. PMID: 18795315

Clinical prediction guides

Incidence of Sympathetic Ophthalmia after Intraocular Surgery: A Systematic Review and Meta-analysis.
Bondok MS, He B, Ka-Lok Tao B, Bondok M, Hussain A, Ing E
Ophthalmology 2024 Jul;131(7):836-844. Epub 2024 Jan 10 doi: 10.1016/j.ophtha.2024.01.014. PMID: 38215990
Sympathetic Ophthalmia: Demographic Characteristics, Clinical Findings, and Treatment Results.
Özdemir Yalçınsoy K, Özdamar Erol Y, Çakar Özdal P
Turk J Ophthalmol 2023 Feb 24;53(1):23-29. doi: 10.4274/tjo.galenos.2022.53383. PMID: 36847630Free PMC Article
The Ruptured Globe, Sympathetic Ophthalmia, and the 14-Day Rule.
Jordan DR, J Dutton J
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):315-324. Epub 2022 Sep 28 doi: 10.1097/IOP.0000000000002068. PMID: 34593714
The role of sex in uveitis and ocular inflammation.
Yeung IY, Popp NA, Chan CC
Int Ophthalmol Clin 2015 Summer;55(3):111-31. doi: 10.1097/IIO.0000000000000072. PMID: 26035764Free PMC Article
Sympathetic ophthalmia.
Dreyer WB Jr, Zegarra H, Zakov ZN, Gutman FA
Am J Ophthalmol 1981 Dec;92(6):816-23. doi: 10.1016/s0002-9394(14)75636-3. PMID: 7315933

Recent systematic reviews

Incidence of Sympathetic Ophthalmia after Intraocular Surgery: A Systematic Review and Meta-analysis.
Bondok MS, He B, Ka-Lok Tao B, Bondok M, Hussain A, Ing E
Ophthalmology 2024 Jul;131(7):836-844. Epub 2024 Jan 10 doi: 10.1016/j.ophtha.2024.01.014. PMID: 38215990
The Risk of Sympathetic Ophthalmia Associated with Open-Globe Injury Management Strategies: A Meta-analysis.
Patterson TJ, Kedzierski A, McKinney D, Ritson J, McLean C, Gu W, Colyer M, McClellan SF, Miller SC, Justin GA, Hoskin AK, Cavuoto K, Leong J, Rousselot Ascarza A, Woreta FA, Miller KE, Caldwell MC, Gensheimer WG, Williamson T, Dhawahir-Scala F, Shah P, Coombes A, Sundar G, Mazzoli RA, Woodcock M, Watson SL, Kuhn F, Halliday S, Gomes RSM, Agrawal R, Blanch RJ
Ophthalmology 2024 May;131(5):557-567. Epub 2023 Dec 10 doi: 10.1016/j.ophtha.2023.12.006. PMID: 38086434
The Incidence of Sympathetic Ophthalmia After Trauma: A Meta-analysis.
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis.
Mehta S, Linton MM, Kempen JH
Am J Ophthalmol 2014 Oct;158(4):676-692.e7. Epub 2014 Jun 28 doi: 10.1016/j.ajo.2014.06.018. PMID: 24983790

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...