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Ophthalmia neonatorum

MedGen UID:
14489
•Concept ID:
C0029076
•
Disease or Syndrome
Synonyms: gonococcal conjunctivitis (neonatorum); gonococcal ophthalmia neonatorum; Neonatal Conjunctivitis; Neonatal conjunctivitis; neonatal conjunctivitis; Ophthalmia Neonatorum; ophthalmia neonatorum
SNOMED CT: Ophthalmia neonatorum (34298002); Neonatal conjunctivitis (34298002)
 
Monarch Initiative: MONDO:0004854

Definition

Inflammation of the conjunctiva in a newborn due to chemical or infectious causes. Aseptic conjunctivitis is often related to the use of prophylactic medications for infectious conjunctivitis. Septic conjunctivitis is related to perinatal exposure to microorganisms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOphthalmia neonatorum

Professional guidelines

PubMed

Ophthalmia neonatorum and the role of primary care.
McKechnie DG, Snelson E
Br J Gen Pract 2020 Dec;70(701):581. Epub 2020 Nov 26 doi: 10.3399/bjgp20X713621. PMID: 33243922Free PMC Article
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921

Recent clinical studies

Etiology

Sexually transmitted infections and HIV in ophthalmology.
Bibb LA, Htet KZ, Waldman CW, Sloan SB
Clin Dermatol 2024 Jan-Feb;42(1):25-37. Epub 2023 Aug 13 doi: 10.1016/j.clindermatol.2023.08.011. PMID: 37582453
Antibiotic prophylaxis for ophthalmia neonatorum in Italy: results from a national survey and the Italian intersociety new position statements.
Mondì V, Tzialla C, Aversa S, Merazzi D, Martinelli S, Araimo G, Massenzi L, Cavallaro G, Gagliardi L, Piersigilli F, Giuffrè M, Lozzi S, Manzoni P, Mosca F, Cetin I, Trojano V, Valensise H, Colacurci N, Orfeo L, Auriti C
Ital J Pediatr 2023 Sep 11;49(1):117. doi: 10.1186/s13052-023-01507-7. PMID: 37697419Free PMC Article
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Diagnosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Ophthalmia Neonatorum.
Tan AK
N Engl J Med 2019 Jan 10;380(2):e2. doi: 10.1056/NEJMicm1808613. PMID: 30625059
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Gonococcal infections.
Hook EW 3rd, Holmes KK
Ann Intern Med 1985 Feb;102(2):229-43. doi: 10.7326/0003-4819-102-2-229. PMID: 3917638
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Therapy

Gonococcal infection: An unresolved problem.
Barberá MJ, Serra-Pladevall J
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Aug-Sep;37(7):458-466. Epub 2019 Feb 4 doi: 10.1016/j.eimc.2018.12.008. PMID: 30732970
The use of povidone-iodine in ophthalmology.
Grzybowski A, Kanclerz P, Myers WG
Curr Opin Ophthalmol 2018 Jan;29(1):19-32. doi: 10.1097/ICU.0000000000000437. PMID: 28984794
Gonococcal infections.
Hook EW 3rd, Holmes KK
Ann Intern Med 1985 Feb;102(2):229-43. doi: 10.7326/0003-4819-102-2-229. PMID: 3917638
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Ophthalmia neonatorum.
Friendly DS
Pediatr Clin North Am 1983 Dec;30(6):1033-42. doi: 10.1016/s0031-3955(16)34500-x. PMID: 6359042

Prognosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921
Chlamydial infections.
Blanchard TJ, Mabey DC
Br J Clin Pract 1994 Jul-Aug;48(4):201-5. PMID: 7917800
Ophthalmia neonatorum.
O'Hara MA
Pediatr Clin North Am 1993 Aug;40(4):715-25. PMID: 8345961

Clinical prediction guides

Ophthalmia Neonatorum, Helen Keller, and the Social Dimensions of Eye Disease.
Harman LE, Margo CE
Cornea 2023 Dec 1;42(12):1601-1604. Epub 2023 Jul 6 doi: 10.1097/ICO.0000000000003332. PMID: 37410593
Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Prevalence of gonococcal conjunctivitis in adults and neonates.
McAnena L, Knowles SJ, Curry A, Cassidy L
Eye (Lond) 2015 Jul;29(7):875-80. Epub 2015 Apr 24 doi: 10.1038/eye.2015.57. PMID: 25907207Free PMC Article
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
Diagnosis of ophthalmia neonatorum.
Winceslaus J, Goh BT, Dunlop EM, Mantell J, Woodland RM, Forsey T, Treharne JD
Br Med J (Clin Res Ed) 1987 Nov 28;295(6610):1377-9. doi: 10.1136/bmj.295.6610.1377. PMID: 3121021Free PMC Article

Recent systematic reviews

Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis.
Vallely LM, Egli-Gany D, Wand H, Pomat WS, Homer CSE, Guy R, Silver B, Rumbold AR, Kaldor JM, Vallely AJ, Low N
Sex Transm Infect 2021 Mar;97(2):104-111. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054653. PMID: 33436505Free PMC Article
Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Antibiotics for treating gonorrhoea in pregnancy.
Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
Cochrane Database Syst Rev 2018 Feb 21;2(2):CD011167. doi: 10.1002/14651858.CD011167.pub2. PMID: 29465747Free PMC Article
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381

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