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Neoplasms, Hormone-Dependent

MedGen UID:
10218
•Concept ID:
C0027661
•
Neoplastic Process
Synonyms: Hormone Dependent Neoplasms; Hormone-Dependent Neoplasm; Hormone-Dependent Neoplasms; Neoplasm, Hormone-Dependent; Neoplasms, Hormone Dependent

Definition

Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Hormone-Dependent

Professional guidelines

PubMed

Managing menopausal symptoms after cancer: an evidence-based approach for primary care.
Marino JL, McNamara HC, Hickey M
Med J Aust 2018 Feb 19;208(3):127-132. doi: 10.5694/mja17.00693. PMID: 29438648
Management of cancer treatment-induced bone loss in early breast and prostate cancer -- a consensus paper of the Belgian Bone Club.
Body JJ, Bergmann P, Boonen S, Boutsen Y, Devogelaer JP, Goemaere S, Reginster JY, Rozenberg S, Kaufman JM
Osteoporos Int 2007 Nov;18(11):1439-50. Epub 2007 Aug 10 doi: 10.1007/s00198-007-0439-4. PMID: 17690930
Treatment of breast cancer with gonadotropin-releasing hormone.
Manni A, Santen R, Harvey H, Lipton A, Max D
Endocr Rev 1986 Feb;7(1):89-94. doi: 10.1210/edrv-7-1-89. PMID: 3082618

Recent clinical studies

Etiology

Targeting obesity-related dysfunction in hormonally driven cancers.
Rubinstein MM, Brown KA, Iyengar NM
Br J Cancer 2021 Aug;125(4):495-509. Epub 2021 Apr 28 doi: 10.1038/s41416-021-01393-y. PMID: 33911195Free PMC Article
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Androgens and esophageal cancer: What do we know?
Sukocheva OA, Li B, Due SL, Hussey DJ, Watson DI
World J Gastroenterol 2015 May 28;21(20):6146-56. doi: 10.3748/wjg.v21.i20.6146. PMID: 26034350Free PMC Article
Operable breast cancer.
Cianfrocca M, Goldstein LJ
Curr Treat Options Oncol 2001 Apr;2(2):157-67. doi: 10.1007/s11864-001-0058-9. PMID: 12057134
Hormonal carcinogenesis.
Henderson BE, Feigelson HS
Carcinogenesis 2000 Mar;21(3):427-33. doi: 10.1093/carcin/21.3.427. PMID: 10688862

Diagnosis

Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Pulmonary lymphangioleiomyomatosis: literature update.
Valentín-Mendoza S, Nieves-Nieves J, Fernández-Medero R, Fernández-Gonzales R, Adorno-Fontánez J, Adorno-Fontánez E
Bol Asoc Med P R 2013;105(3):64-9. PMID: 24282925
MicroRNAs in androgen-dependent PCa.
Zhu KC, Lu JJ, Xu XL, Sun JM
Front Biosci (Landmark Ed) 2013 Jan 1;18(2):748-55. doi: 10.2741/4137. PMID: 23276959
Prostate cancer stem cells.
Tu SM, Lin SH
Clin Genitourin Cancer 2012 Jun;10(2):69-76. Epub 2012 Mar 14 doi: 10.1016/j.clgc.2012.01.002. PMID: 22421313Free PMC Article
MicroRNAs and prostate cancer.
Coppola V, De Maria R, Bonci D
Endocr Relat Cancer 2010 Mar;17(1):F1-17. Epub 2010 Jan 29 doi: 10.1677/ERC-09-0172. PMID: 19779034

Therapy

Targeting obesity-related dysfunction in hormonally driven cancers.
Rubinstein MM, Brown KA, Iyengar NM
Br J Cancer 2021 Aug;125(4):495-509. Epub 2021 Apr 28 doi: 10.1038/s41416-021-01393-y. PMID: 33911195Free PMC Article
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial.
Kyriakopoulos CE, Chen YH, Carducci MA, Liu G, Jarrard DF, Hahn NM, Shevrin DH, Dreicer R, Hussain M, Eisenberger M, Kohli M, Plimack ER, Vogelzang NJ, Picus J, Cooney MM, Garcia JA, DiPaola RS, Sweeney CJ
J Clin Oncol 2018 Apr 10;36(11):1080-1087. Epub 2018 Jan 31 doi: 10.1200/JCO.2017.75.3657. PMID: 29384722Free PMC Article
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560
Triple-negative breast cancer.
Bartsch R, Ziebermayr R, Zielinski CC, Steger GG
Wien Med Wochenschr 2010 Apr;160(7-8):174-81. doi: 10.1007/s10354-010-0773-6. PMID: 20473728
Could aminoglutethimide replace adrenalectomy?
Harris AL
Breast Cancer Res Treat 1985;6(3):201-11. doi: 10.1007/BF01806770. PMID: 3912013

Prognosis

Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Obesity and cancer: mechanistic insights from transdisciplinary studies.
Allott EH, Hursting SD
Endocr Relat Cancer 2015 Dec;22(6):R365-86. Epub 2015 Sep 15 doi: 10.1530/ERC-15-0400. PMID: 26373570Free PMC Article
Chemotherapy in Prostate Cancer.
Hurwitz M
Curr Oncol Rep 2015 Oct;17(10):44. doi: 10.1007/s11912-015-0468-7. PMID: 26216506
MicroRNAs and prostate cancer.
Coppola V, De Maria R, Bonci D
Endocr Relat Cancer 2010 Mar;17(1):F1-17. Epub 2010 Jan 29 doi: 10.1677/ERC-09-0172. PMID: 19779034
Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer.
Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, Cristofanilli M, Hortobagyi GN, Pusztai L
J Clin Oncol 2008 Mar 10;26(8):1275-81. Epub 2008 Feb 4 doi: 10.1200/JCO.2007.14.4147. PMID: 18250347

Clinical prediction guides

Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers.
Chimento A, De Luca A, Avena P, De Amicis F, Casaburi I, Sirianni R, Pezzi V
Int J Mol Sci 2022 Jan 22;23(3) doi: 10.3390/ijms23031242. PMID: 35163166Free PMC Article
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Androgens and esophageal cancer: What do we know?
Sukocheva OA, Li B, Due SL, Hussey DJ, Watson DI
World J Gastroenterol 2015 May 28;21(20):6146-56. doi: 10.3748/wjg.v21.i20.6146. PMID: 26034350Free PMC Article
MicroRNAs and prostate cancer.
Coppola V, De Maria R, Bonci D
Endocr Relat Cancer 2010 Mar;17(1):F1-17. Epub 2010 Jan 29 doi: 10.1677/ERC-09-0172. PMID: 19779034
18F-Fluoroestradiol.
Sundararajan L, Linden HM, Link JM, Krohn KA, Mankoff DA
Semin Nucl Med 2007 Nov;37(6):470-6. doi: 10.1053/j.semnuclmed.2007.08.003. PMID: 17920354

Recent systematic reviews

Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals-A systematic review.
McFarlane T, Zajac JD, Cheung AS
Clin Endocrinol (Oxf) 2018 Dec;89(6):700-711. Epub 2018 Sep 18 doi: 10.1111/cen.13835. PMID: 30107028
Fulvestrant for hormone-sensitive metastatic breast cancer.
Lee CI, Goodwin A, Wilcken N
Cochrane Database Syst Rev 2017 Jan 3;1(1):CD011093. doi: 10.1002/14651858.CD011093.pub2. PMID: 28043088Free PMC Article
Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies.
Karasneh RA, Murray LJ, Cardwell CR
Int J Cancer 2017 Mar 1;140(5):1035-1041. Epub 2016 Nov 27 doi: 10.1002/ijc.30520. PMID: 27861859
Systematic review on hormone receptor testing in breast cancer.
Nofech-Mozes S, Vella ET, Dhesy-Thind S, Hagerty KL, Mangu PB, Temin S, Hanna WM
Appl Immunohistochem Mol Morphol 2012 May;20(3):214-63. doi: 10.1097/PAI.0b013e318234aa12. PMID: 22505008
The mythology of hormone replacement therapy.
Hartmann BW, Huber JC
Br J Obstet Gynaecol 1997 Feb;104(2):163-8. doi: 10.1111/j.1471-0528.1997.tb11038.x. PMID: 9070132

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