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Nematoda infectious disease

MedGen UID:
45025
•Concept ID:
C0027583
•
Disease or Syndrome
Synonyms: Infection, Nematode; Infections, Nematode; Nematode Infection; Nematode Infections
SNOMED CT: Nematode infection (84706005); Nematodiasis (84706005); Infection caused by Nematoda (84706005)
 
Monarch Initiative: MONDO:0005871

Definition

Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in humans. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans. [from MONDO]

Professional guidelines

PubMed

Angiostrongylus cantonensis in travelers: clinical manifestations, diagnosis, and treatment.
Ansdell V, Wattanagoon Y
Curr Opin Infect Dis 2018 Oct;31(5):399-408. doi: 10.1097/QCO.0000000000000481. PMID: 30138142
Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?
Liao C, Cheng X, Liu M, Wang X, Boireau P
Anticancer Agents Med Chem 2018;18(8):1091-1099. doi: 10.2174/1871520617666171121115847. PMID: 29173187Free PMC Article
Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.
Mejia R, Nutman TB
Curr Opin Infect Dis 2012 Aug;25(4):458-63. doi: 10.1097/QCO.0b013e3283551dbd. PMID: 22691685Free PMC Article

Recent clinical studies

Etiology

Strongyloidiasis-related lung involvement: too much of a bad thing.
Barkati S, Greenaway C, Libman M
Curr Opin Infect Dis 2023 Jun 1;36(3):203-208. Epub 2023 Mar 28 doi: 10.1097/QCO.0000000000000915. PMID: 37093059
IgE-mediated Anisakis allergy in children.
Pontone M, Giovannini M, Barni S, Mori F, Venturini E, Galli L, Valleriani C, Vecillas LL, Sackesen C, Lopata AL, Buyuktiryaki B
Allergol Immunopathol (Madr) 2023;51(1):98-109. Epub 2023 Jan 1 doi: 10.15586/aei.v51i1.692. PMID: 36617828
Neutrophils: Friend or foe in Filariasis?
Ajendra J, Allen JE
Parasite Immunol 2022 Jun;44(6):e12918. Epub 2022 May 25 doi: 10.1111/pim.12918. PMID: 35373850
Imported onchocerciasis in migrants and travelers.
Showler AJ, Nutman TB
Curr Opin Infect Dis 2018 Oct;31(5):393-398. doi: 10.1097/QCO.0000000000000483. PMID: 30113326Free PMC Article
Paediatric vulvovaginitis.
O'Brien TJ
Australas J Dermatol 1995 Nov;36(4):216-8. doi: 10.1111/j.1440-0960.1995.tb00979.x. PMID: 8593114

Diagnosis

Strongyloidiasis.
Gordon CA, Utzinger J, Muhi S, Becker SL, Keiser J, Khieu V, Gray DJ
Nat Rev Dis Primers 2024 Jan 25;10(1):6. doi: 10.1038/s41572-023-00490-x. PMID: 38272922
Human strongyloidiasis: complexities and pathways forward.
Buonfrate D, Bradbury RS, Watts MR, Bisoffi Z
Clin Microbiol Rev 2023 Dec 20;36(4):e0003323. Epub 2023 Nov 8 doi: 10.1128/cmr.00033-23. PMID: 37937980Free PMC Article
Strongyloides stercoralis.
Czeresnia JM, Weiss LM
Lung 2022 Apr;200(2):141-148. Epub 2022 Apr 9 doi: 10.1007/s00408-022-00528-z. PMID: 35396957Free PMC Article
Toxocariasis: a silent threat with a progressive public health impact.
Chen J, Liu Q, Liu GH, Zheng WB, Hong SJ, Sugiyama H, Zhu XQ, Elsheikha HM
Infect Dis Poverty 2018 Jun 13;7(1):59. doi: 10.1186/s40249-018-0437-0. PMID: 29895324Free PMC Article
Human toxocariasis.
Ma G, Holland CV, Wang T, Hofmann A, Fan CK, Maizels RM, Hotez PJ, Gasser RB
Lancet Infect Dis 2018 Jan;18(1):e14-e24. Epub 2017 Aug 3 doi: 10.1016/S1473-3099(17)30331-6. PMID: 28781085

Therapy

Trigonelline is an NAD(+) precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN
Nat Metab 2024 Mar;6(3):433-447. Epub 2024 Mar 19 doi: 10.1038/s42255-024-00997-x. PMID: 38504132Free PMC Article
Strongyloidiasis.
Gordon CA, Utzinger J, Muhi S, Becker SL, Keiser J, Khieu V, Gray DJ
Nat Rev Dis Primers 2024 Jan 25;10(1):6. doi: 10.1038/s41572-023-00490-x. PMID: 38272922
Human strongyloidiasis: complexities and pathways forward.
Buonfrate D, Bradbury RS, Watts MR, Bisoffi Z
Clin Microbiol Rev 2023 Dec 20;36(4):e0003323. Epub 2023 Nov 8 doi: 10.1128/cmr.00033-23. PMID: 37937980Free PMC Article
Imported onchocerciasis in migrants and travelers.
Showler AJ, Nutman TB
Curr Opin Infect Dis 2018 Oct;31(5):393-398. doi: 10.1097/QCO.0000000000000483. PMID: 30113326Free PMC Article
Pharmacotherapy of ascariasis.
St Georgiev V
Expert Opin Pharmacother 2001 Feb;2(2):223-39. doi: 10.1517/14656566.2.2.223. PMID: 11336582

Prognosis

Human dirofilariosis in Austria: the past, the present, the future.
Riebenbauer K, Weber PB, Walochnik J, Karlhofer F, Winkler S, Dorfer S, Auer H, Valencak J, Laimer M, Handisurya A
Parasit Vectors 2021 Apr 29;14(1):227. doi: 10.1186/s13071-021-04696-4. PMID: 33926526Free PMC Article
Imported onchocerciasis in migrants and travelers.
Showler AJ, Nutman TB
Curr Opin Infect Dis 2018 Oct;31(5):393-398. doi: 10.1097/QCO.0000000000000483. PMID: 30113326Free PMC Article
Factors affecting onchocerciasis transmission: lessons for infection control.
Cheke RA
Expert Rev Anti Infect Ther 2017 Apr;15(4):377-386. Epub 2017 Feb 3 doi: 10.1080/14787210.2017.1286980. PMID: 28117596
Mucocutaneous manifestations of helminth infections: Nematodes.
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):929-44; quiz 945-6. doi: 10.1016/j.jaad.2014.11.034. PMID: 26568337
Role of pathogens in multiple sclerosis.
Libbey JE, Cusick MF, Fujinami RS
Int Rev Immunol 2014 Jul-Aug;33(4):266-83. Epub 2013 Nov 22 doi: 10.3109/08830185.2013.823422. PMID: 24266364Free PMC Article

Clinical prediction guides

Clinical and laboratory features of Strongyloides stercoralis infection at diagnosis and after treatment: a systematic review and meta-analysis.
Buonfrate D, Fittipaldo A, Vlieghe E, Bottieau E
Clin Microbiol Infect 2021 Nov;27(11):1621-1628. Epub 2021 Jul 26 doi: 10.1016/j.cmi.2021.07.016. PMID: 34325063
Human dirofilariosis in Austria: the past, the present, the future.
Riebenbauer K, Weber PB, Walochnik J, Karlhofer F, Winkler S, Dorfer S, Auer H, Valencak J, Laimer M, Handisurya A
Parasit Vectors 2021 Apr 29;14(1):227. doi: 10.1186/s13071-021-04696-4. PMID: 33926526Free PMC Article
Behavioural and clinical predictors for Loiasis.
Mischlinger J, Veletzky L, Tazemda-Kuitsouc GB, Pitzinger P, Matsegui PB, Gmeiner M, Lagler H, Gebru T, Held J, Mordmüller B, Ramharter M
J Glob Health 2018 Jun;8(1):010413. doi: 10.7189/jogh.08.010413. PMID: 29497506Free PMC Article
Factors affecting onchocerciasis transmission: lessons for infection control.
Cheke RA
Expert Rev Anti Infect Ther 2017 Apr;15(4):377-386. Epub 2017 Feb 3 doi: 10.1080/14787210.2017.1286980. PMID: 28117596
Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes.
Grencis RK
Annu Rev Immunol 2015;33:201-25. Epub 2014 Dec 17 doi: 10.1146/annurev-immunol-032713-120218. PMID: 25533702

Recent systematic reviews

Severe strongyloidiasis: a systematic review and meta-analysis of 339 cases.
Rojas OC, Montoya AM, Villanueva-Lozano H, Carrion-Alvarez D
Trans R Soc Trop Med Hyg 2023 Oct 3;117(10):682-696. doi: 10.1093/trstmh/trad032. PMID: 37300462
Global prevalence of Trichinella in pigs: A systematic review and meta-analysis.
Eslahi AV, KarimiPourSaryazdi A, Olfatifar M, de Carvalho LMM, Foroutan M, Karim MR, Badri M, Ketzis JK
Vet Med Sci 2022 Nov;8(6):2466-2481. Epub 2022 Sep 22 doi: 10.1002/vms3.951. PMID: 36137293Free PMC Article
Global prevalence and epidemiology of Strongyloides stercoralis in dogs: a systematic review and meta-analysis.
Eslahi AV, Hashemipour S, Olfatifar M, Houshmand E, Hajialilo E, Mahmoudi R, Badri M, Ketzis JK
Parasit Vectors 2022 Jan 10;15(1):21. doi: 10.1186/s13071-021-05135-0. PMID: 35012614Free PMC Article
Human dirofilariosis in Austria: the past, the present, the future.
Riebenbauer K, Weber PB, Walochnik J, Karlhofer F, Winkler S, Dorfer S, Auer H, Valencak J, Laimer M, Handisurya A
Parasit Vectors 2021 Apr 29;14(1):227. doi: 10.1186/s13071-021-04696-4. PMID: 33926526Free PMC Article
Toxocara spp. infection and risk of childhood asthma: A systematic review and meta-analysis.
Aghaei S, Riahi SM, Rostami A, Mohammadzadeh I, Javanian M, Tohidi E, Foroutan M, Esmaeili Dooki M
Acta Trop 2018 Jun;182:298-304. Epub 2018 Mar 21 doi: 10.1016/j.actatropica.2018.03.022. PMID: 29573999

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