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Necrotizing scleritis

MedGen UID:
6542
•Concept ID:
C0027547
•
Disease or Syndrome
Synonyms: Necrotizing Scleritides; Necrotizing Scleritis; Scleritides, Necrotizing; Scleritis, Necrotizing
SNOMED CT: Necrotizing scleritis (95797003)
 
Monarch Initiative: MONDO:0040699

Definition

A severe form of scleritis with subtypes: necrotising zonal granulomatous inflammation, diffuse non-granulomatous chronic inflammation, mixed pattern of acute purulent inflammation mixed with granulomatous inflammation and sarcoidal pattern. [from MONDO]

Professional guidelines

PubMed

Etiology, Pathogens, Clinical Features and Treatment of Bacterial Scleritis.
Chen X, Lv X, Yang L, Bai F, Liu X
Semin Ophthalmol 2023 Aug;38(6):521-528. Epub 2023 Feb 16 doi: 10.1080/08820538.2023.2177117. PMID: 36794923
Clinical profile and management of granulomatosis with polyangiitis-associated scleritis from a tertiary care hospital in South India.
Mohanan-Earatt A, Biswas J
Indian J Ophthalmol 2023 Jan;71(1):146-152. doi: 10.4103/ijo.IJO_1411_22. PMID: 36588225Free PMC Article
Current Approach for the Diagnosis and Management of Noninfective Scleritis.
Dutta Majumder P, Agrawal R, McCluskey P, Biswas J
Asia Pac J Ophthalmol (Phila) 2020 Dec 7;10(2):212-223. doi: 10.1097/APO.0000000000000341. PMID: 33290287

Recent clinical studies

Etiology

Necrotizing Scleritis: A Review.
Dutta Majumder P, Agarwal S, Shah M, Srinivasan B, K P, Iyer G, Sharma N, Biswas J, McCluskey P
Ocul Immunol Inflamm 2024 Sep;32(7):1405-1419. Epub 2023 Jun 6 doi: 10.1080/09273948.2023.2206898. PMID: 37279404
Etiology, Pathogens, Clinical Features and Treatment of Bacterial Scleritis.
Chen X, Lv X, Yang L, Bai F, Liu X
Semin Ophthalmol 2023 Aug;38(6):521-528. Epub 2023 Feb 16 doi: 10.1080/08820538.2023.2177117. PMID: 36794923
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Scleritis therapy.
Sainz de la Maza M, Molina N, Gonzalez-Gonzalez LA, Doctor PP, Tauber J, Foster CS
Ophthalmology 2012 Jan;119(1):51-8. Epub 2011 Oct 19 doi: 10.1016/j.ophtha.2011.07.043. PMID: 22015381

Diagnosis

Necrotizing Scleritis: A Review.
Dutta Majumder P, Agarwal S, Shah M, Srinivasan B, K P, Iyer G, Sharma N, Biswas J, McCluskey P
Ocul Immunol Inflamm 2024 Sep;32(7):1405-1419. Epub 2023 Jun 6 doi: 10.1080/09273948.2023.2206898. PMID: 37279404
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Current Approach for the Diagnosis and Management of Noninfective Scleritis.
Dutta Majumder P, Agrawal R, McCluskey P, Biswas J
Asia Pac J Ophthalmol (Phila) 2020 Dec 7;10(2):212-223. doi: 10.1097/APO.0000000000000341. PMID: 33290287
Necrotizing Scleritis.
Lorenzana Blanco N, Alejandre Alba N
N Engl J Med 2020 Nov 5;383(19):e110. doi: 10.1056/NEJMicm2004836. PMID: 33211932

Therapy

Necrotizing Scleritis: A Review.
Dutta Majumder P, Agarwal S, Shah M, Srinivasan B, K P, Iyer G, Sharma N, Biswas J, McCluskey P
Ocul Immunol Inflamm 2024 Sep;32(7):1405-1419. Epub 2023 Jun 6 doi: 10.1080/09273948.2023.2206898. PMID: 37279404
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Necrotizing Scleritis.
Lorenzana Blanco N, Alejandre Alba N
N Engl J Med 2020 Nov 5;383(19):e110. doi: 10.1056/NEJMicm2004836. PMID: 33211932
Scleritis therapy.
Sainz de la Maza M, Molina N, Gonzalez-Gonzalez LA, Doctor PP, Tauber J, Foster CS
Ophthalmology 2012 Jan;119(1):51-8. Epub 2011 Oct 19 doi: 10.1016/j.ophtha.2011.07.043. PMID: 22015381
Acanthamoeba sclerokeratitis.
Ebrahimi KB, Green WR, Grebe R, Jun AS
Graefes Arch Clin Exp Ophthalmol 2009 Feb;247(2):283-6. Epub 2008 Oct 9 doi: 10.1007/s00417-008-0955-8. PMID: 18843498

Prognosis

Pattern of Scleritis in an Egyptian Cohort.
Abd El Latif E, Seleet MM, El Hennawi H, Abdulbadiea Rashed M, Elbarbary H, Sabry K, Abdelmonagy Ibrahim M
Ocul Immunol Inflamm 2019;27(6):890-896. Epub 2018 Nov 9 doi: 10.1080/09273948.2018.1544372. PMID: 30412434
Clinical Profile of Scleritis in Children.
Majumder PD, Ali S, George A, Ganesh S, Biswas J
Ocul Immunol Inflamm 2019;27(4):535-539. Epub 2018 Jan 25 doi: 10.1080/09273948.2017.1423333. PMID: 29370565
Scleritis Due to Histoplasmosis.
Dalvin LA, Thom SB, García JJ, Fadel HJ, Baratz KH
Cornea 2016 Mar;35(3):402-4. doi: 10.1097/ICO.0000000000000733. PMID: 26764883
Ocular inflammatory diseases associated with rheumatoid arthritis.
Artifoni M, Rothschild PR, Brézin A, Guillevin L, Puéchal X
Nat Rev Rheumatol 2014 Feb;10(2):108-16. Epub 2013 Dec 10 doi: 10.1038/nrrheum.2013.185. PMID: 24323074
Acanthamoeba sclerokeratitis.
Ebrahimi KB, Green WR, Grebe R, Jun AS
Graefes Arch Clin Exp Ophthalmol 2009 Feb;247(2):283-6. Epub 2008 Oct 9 doi: 10.1007/s00417-008-0955-8. PMID: 18843498

Clinical prediction guides

Etiology, Pathogens, Clinical Features and Treatment of Bacterial Scleritis.
Chen X, Lv X, Yang L, Bai F, Liu X
Semin Ophthalmol 2023 Aug;38(6):521-528. Epub 2023 Feb 16 doi: 10.1080/08820538.2023.2177117. PMID: 36794923
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Cataract Surgery in the Setting of Scleritis.
Palkar A, Sudharshan S, George AE, Ganesh SK, Biswas J, Dutta Majumder P
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1540-1543. Epub 2020 May 28 doi: 10.1080/09273948.2020.1754434. PMID: 32463347
Clinical Profile of Scleritis in Children.
Majumder PD, Ali S, George A, Ganesh S, Biswas J
Ocul Immunol Inflamm 2019;27(4):535-539. Epub 2018 Jan 25 doi: 10.1080/09273948.2017.1423333. PMID: 29370565
Clinical characteristics and ocular complications of patients with scleritis in Japanese.
Tanaka R, Kaburaki T, Ohtomo K, Takamoto M, Komae K, Numaga J, Fujino Y, Aihara M
Jpn J Ophthalmol 2018 Jul;62(4):517-524. Epub 2018 May 23 doi: 10.1007/s10384-018-0600-y. PMID: 29796754

Recent systematic reviews

Necrotizing Scleritis and Rheumatoid Arthritis: A Clinical Case Report Supported by A Brief Review with Risk of Bias Analysis.
Busnelo Moreno C, Gonçalves Cruz JC, Zotarelli-Filho IJ, de Lima Batista Ribeiro Junior M, Colombo Barboza MN, Colombo Barboza GN, Gouvêa Barioni MF
Curr Rheumatol Rev 2023 Jun 5;19(3):367-372. doi: 10.2174/1573397119666230222093007. PMID: 36809968
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article

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