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Myositis ossificans

MedGen UID:
6503
•Concept ID:
C0027122
•
Disease or Syndrome
Synonym: Myositis Ossificans
SNOMED CT: Muscle calcification and ossification (44551007); Muscle ossification (44551007); Muscular ossification (44551007); Myositis ossificans (44551007)
 
Monarch Initiative: MONDO:0003964

Definition

A self-limited benign neoplasm characterized by a zonal architecture. It is composed of spindle cells oriented randomly or in short intersecting fascicles. Peripherally, the spindle cells merge with osteoblasts that rim and populate ill-defined trabeculae and sheets of unmineralized woven bone, which is surrounded by well-formed trabecular and cortical-type bone that remodels into lamellar bone. Treatment is usually simple excision. Prognosis is excellent; recurrence is uncommon. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyositis ossificans

Professional guidelines

PubMed

Fasciitis ossificans: imaging features, histology, and differential diagnosis.
Dhillon P, Jebastin Thangaiah J, Anderson TL, Tiegs-Heiden CA
Clin Radiol 2023 Sep;78(9):697-702. Epub 2023 Jun 2 doi: 10.1016/j.crad.2023.05.008. PMID: 37331849
Treatment of muscle haematomas in haemophiliacs with special emphasis on percutaneous drainage.
De la Corte-Rodriguez H, Rodriguez-Merchan EC
Blood Coagul Fibrinolysis 2014 Dec;25(8):787-94. doi: 10.1097/MBC.0000000000000159. PMID: 24914744
Muscle contusion injuries: current treatment options.
Beiner JM, Jokl P
J Am Acad Orthop Surg 2001 Jul-Aug;9(4):227-37. doi: 10.5435/00124635-200107000-00002. PMID: 11476532

Recent clinical studies

Etiology

Heterotopic Ossification after Trauma.
Lawand J, Loeffelholz Z, Khurshid B, Barcak E
Orthop Clin North Am 2023 Jan;54(1):37-46. doi: 10.1016/j.ocl.2022.08.007. PMID: 36402509
Contemporary perspectives on heterotopic ossification.
Hwang CD, Pagani CA, Nunez JH, Cherief M, Qin Q, Gomez-Salazar M, Kadaikal B, Kang H, Chowdary AR, Patel N, James AW, Levi B
JCI Insight 2022 Jul 22;7(14) doi: 10.1172/jci.insight.158996. PMID: 35866484Free PMC Article
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
J Bone Miner Res 2022 Oct;37(10):1891-1902. Epub 2022 Aug 17 doi: 10.1002/jbmr.4655. PMID: 35854638Free PMC Article
Trismus in the paediatric population.
Shires PM, Chow G
Dev Med Child Neurol 2015 Apr;57(4):339-43. Epub 2014 Nov 19 doi: 10.1111/dmcn.12636. PMID: 25407568
Heterotopic ossification.
Kaplan FS, Glaser DL, Hebela N, Shore EM
J Am Acad Orthop Surg 2004 Mar-Apr;12(2):116-25. doi: 10.5435/00124635-200403000-00007. PMID: 15089085

Diagnosis

Extra-skeletal osteosarcoma: a review.
Hesni S, Lindsay D, O'Donnell P, Saifuddin A
Skeletal Radiol 2023 Apr;52(4):633-648. Epub 2022 Oct 4 doi: 10.1007/s00256-022-04193-4. PMID: 36194245
Circumscribed myositis ossificans.
Wendling D, Chouk M, Guillot X, Aubry S, Prati C
Joint Bone Spine 2021 Mar;88(2):105119. Epub 2020 Dec 17 doi: 10.1016/j.jbspin.2020.105119. PMID: 33346106
Fibrodysplasia ossificans progressiva in China.
She D, Zhang K
Bone 2018 Apr;109:101-103. Epub 2017 Nov 22 doi: 10.1016/j.bone.2017.11.016. PMID: 29175272
Myositis Ossificans.
Walczak BE, Johnson CN, Howe BM
J Am Acad Orthop Surg 2015 Oct;23(10):612-22. Epub 2015 Aug 28 doi: 10.5435/JAAOS-D-14-00269. PMID: 26320160
Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons.
Pignolo RJ, Shore EM, Kaplan FS
Pediatr Endocrinol Rev 2013 Jun;10 Suppl 2(0 2):437-48. PMID: 23858627Free PMC Article

Therapy

Current and emerging treatment modalities for fibrodysplasia ossificans progressiva.
Gençel D, Erbil NN, Demiryürek Ş, Demiryürek AT
Expert Opin Pharmacother 2024 Nov;25(16):2225-2234. Epub 2024 Oct 28 doi: 10.1080/14656566.2024.2422548. PMID: 39451784
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial.
Di Rocco M, Forleo-Neto E, Pignolo RJ, Keen R, Orcel P, Funck-Brentano T, Roux C, Kolta S, Madeo A, Bubbear JS, Tabarkiewicz J, Szczepanek M, Bachiller-Corral J, Cheung AM, Dahir KM, Botman E, Raijmakers PG, Al Mukaddam M, Tile L, Portal-Celhay C, Sarkar N, Hou P, Musser BJ, Boyapati A, Mohammadi K, Mellis SJ, Rankin AJ, Economides AN, Trotter DG, Herman GA, O'Meara SJ, DelGizzi R, Weinreich DM, Yancopoulos GD, Eekhoff EMW, Kaplan FS
Nat Med 2023 Oct;29(10):2615-2624. Epub 2023 Sep 28 doi: 10.1038/s41591-023-02561-8. PMID: 37770652Free PMC Article
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
J Bone Miner Res 2022 Oct;37(10):1891-1902. Epub 2022 Aug 17 doi: 10.1002/jbmr.4655. PMID: 35854638Free PMC Article
Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.
Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, di Rocco M, Delai PLR, Diecidue RJ, Madhuri V, Cho TJ, Morhart R, Friedman CS, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D
Hum Gene Ther 2022 Aug;33(15-16):782-788. doi: 10.1089/hum.2022.023. PMID: 35502479Free PMC Article
Muscle injuries: optimising recovery.
Järvinen TA, Järvinen TL, Kääriäinen M, Aärimaa V, Vaittinen S, Kalimo H, Järvinen M
Best Pract Res Clin Rheumatol 2007 Apr;21(2):317-31. doi: 10.1016/j.berh.2006.12.004. PMID: 17512485

Prognosis

Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva.
Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS
BMC Med Res Methodol 2023 Nov 13;23(1):269. doi: 10.1186/s12874-023-02080-7. PMID: 37957586Free PMC Article
Chondro-Osseous Lesions of Soft Tissue.
Cho SJ, Horvai A
Surg Pathol Clin 2015 Sep;8(3):419-44. doi: 10.1016/j.path.2015.05.004. PMID: 26297064
The imaging of myositis ossificans.
Tyler P, Saifuddin A
Semin Musculoskelet Radiol 2010 Jun;14(2):201-16. Epub 2010 May 18 doi: 10.1055/s-0030-1253161. PMID: 20486028
Inherited ossifying diseases.
Job-Deslandre C
Joint Bone Spine 2004 Mar;71(2):98-101. doi: 10.1016/s1297-319x(03)00130-1. PMID: 15116703
Heterotopic ossification.
Kaplan FS, Glaser DL, Hebela N, Shore EM
J Am Acad Orthop Surg 2004 Mar-Apr;12(2):116-25. doi: 10.5435/00124635-200403000-00007. PMID: 15089085

Clinical prediction guides

The Fibrodysplasia Ossificans Progressiva Physical Function Questionnaire (FOP-PFQ): A patient-reported, disease-specific measure.
Pignolo RJ, Kimel M, Whalen J, Kawata AK, Artyomenko A, Kaplan FS
Bone 2023 Mar;168:116642. Epub 2022 Dec 13 doi: 10.1016/j.bone.2022.116642. PMID: 36526263
Bone morphogenetic protein signaling is a possible therapeutic target in gynecologic cancer.
Fukuda T, Suzuki E, Fukuda R
Cancer Sci 2023 Mar;114(3):722-729. Epub 2022 Dec 16 doi: 10.1111/cas.15682. PMID: 36468782Free PMC Article
Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.
Nagar G, Mittal P, Gupta SRR, Pahuja M, Sanger M, Mishra R, Singh A, Singh IK
Brief Funct Genomics 2023 Apr 13;22(2):123-142. doi: 10.1093/bfgp/elac026. PMID: 36003055
Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC
Orphanet J Rare Dis 2022 Mar 4;17(1):107. doi: 10.1186/s13023-022-02246-4. PMID: 35246171Free PMC Article
Heterotopic ossification: a review.
McCarthy EF, Sundaram M
Skeletal Radiol 2005 Oct;34(10):609-19. Epub 2005 Aug 25 doi: 10.1007/s00256-005-0958-z. PMID: 16132978

Recent systematic reviews

Pin-Related Complications in Computer Navigated and Robotic-Assisted Knee Arthroplasty: A Systematic Review.
Thomas TL, Goh GS, Nguyen MK, Lonner JH
J Arthroplasty 2022 Nov;37(11):2291-2307.e2. Epub 2022 May 7 doi: 10.1016/j.arth.2022.05.012. PMID: 35537611
When Limb Surgery Has Become the Only Life-Saving Therapy in FOP: A Case Report and Systematic Review of the Literature.
Botman E, Treurniet S, Lubbers WD, Schwarte LA, Schober PR, Sabelis L, Peters EJG, van Schie A, de Vries R, Grunwald Z, Smilde BJ, Nieuwenhuijzen JA, Visser M, Micha D, Bravenboer N, Coen Netelenbos J, Teunissen BP, de Graaf P, Raijmakers PGHM, Smit JM, Eekhoff EMW
Front Endocrinol (Lausanne) 2020;11:570. Epub 2020 Aug 21 doi: 10.3389/fendo.2020.00570. PMID: 32973683Free PMC Article
A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders.
Treurniet S, Eekhoff EMW, Schmidt FN, Micha D, Busse B, Bravenboer N
Front Endocrinol (Lausanne) 2020;11:399. Epub 2020 Jun 23 doi: 10.3389/fendo.2020.00399. PMID: 32714279Free PMC Article
Aspiration of the elbow joint for treating radial head fractures.
Foocharoen T, Foocharoen C, Laopaiboon M, Tiamklang T
Cochrane Database Syst Rev 2014 Nov 22;2014(11):CD009949. doi: 10.1002/14651858.CD009949.pub2. PMID: 25416525Free PMC Article
Interventions for treating acute elbow dislocations in adults.
Taylor F, Sims M, Theis JC, Herbison GP
Cochrane Database Syst Rev 2012 Apr 18;2012(4):CD007908. doi: 10.1002/14651858.CD007908.pub2. PMID: 22513954Free PMC Article

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