Muscle flaccidity

MedGen UID:: 10131
•Concept ID:: C0026825
•: Sign or Symptom

Synonyms:	Flaccid Muscle Tone; Flaccidity, Muscle; Flaccidity, Muscular; Muscle Flaccidity; Muscle Tone, Flaccid; Muscular Flaccidities; Muscular Flaccidity
SNOMED CT:	Flaccidity (397488002); Muscular flaccidity (186611004); Flaccid muscle (186611004); Flaccidity of muscle (186611004); Floppy muscle (186611004)

HPO:	HP:0010547

Definition

A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMuscle flaccidity

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the musculature
    - Abnormal muscle physiology
      - Muscle weakness
        Muscle flaccidity
        Episodic flaccid weakness

Professional guidelines

PubMed

Botulinum A exotoxin for the management of platysma bands.

Matarasso A, Matarasso SL, Brandt FS, Bellman B
Plast Reconstr Surg 1999 Feb;103(2):645-52; discussion 653-5. doi: 10.1097/00006534-199902000-00043. PMID: 9950556

See all (1)

Recent clinical studies

Etiology

Glucocorticoids may trigger attacks in several types of periodic paralysis.

Arzel-Hézode M, McGoey S, Sternberg D, Vicart S, Eymard B, Fontaine B
Neuromuscul Disord 2009 Mar;19(3):217-9. Epub 2009 Feb 7 doi: 10.1016/j.nmd.2008.12.008. PMID: 19201608

Botulinum A exotoxin for the management of platysma bands.

Matarasso A, Matarasso SL, Brandt FS, Bellman B
Plast Reconstr Surg 1999 Feb;103(2):645-52; discussion 653-5. doi: 10.1097/00006534-199902000-00043. PMID: 9950556

When does your liposuction patient require an abdominoplasty?

Matarasso A, Matarasso SL
Dermatol Surg 1997 Dec;23(12):1151-60. doi: 10.1111/j.1524-4725.1997.tb00465.x. PMID: 9426659

The effects of functional electrical stimulation on shoulder subluxation, arm function recovery, and shoulder pain in hemiplegic stroke patients.

Faghri PD, Rodgers MM, Glaser RM, Bors JG, Ho C, Akuthota P
Arch Phys Med Rehabil 1994 Jan;75(1):73-9. PMID: 8291967

The effects of thiopental sodium on fentanyl-induced muscle rigidity in a human model.

Vacanti CA, Silbert BS, Vacanti FX
J Clin Anesth 1991 Sep-Oct;3(5):395-8. doi: 10.1016/0952-8180(91)90183-n. PMID: 1931065

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Diagnosis

Translational Value of Skilled Reaching Assessment in Clinical and Preclinical Studies on Motor Recovery After Stroke.

van Lieshout ECC, Boonzaier J, Pel AJ, van Heijningen CL, Vink JJ, Visser-Meily JMA, van Tilborg GAF, Dijkhuizen RM
Neurorehabil Neural Repair 2021 May;35(5):457-467. Epub 2021 Apr 7 doi: 10.1177/15459683211005022. PMID: 33825580 Free PMC Article

Intrathecal Baclofen Overdose With Paradoxical Autonomic Features Mimicking Withdrawal.

Parker-Pitts CK, Weymouth CW, Frawley MT
J Emerg Med 2020 Apr;58(4):616-619. Epub 2020 Mar 20 doi: 10.1016/j.jemermed.2019.12.031. PMID: 32204996

Survival in young children after drowning: brain evoked potentials as outcome predictors.

Rappaport M, Maloney JR, Ortega H, Fetzer D, Hall K
Clin Electroencephalogr 1985 Oct;16(4):183-91. doi: 10.1177/155005948501600404. PMID: 4075533

See all (3)

Therapy

Intrathecal Baclofen Overdose With Paradoxical Autonomic Features Mimicking Withdrawal.

Parker-Pitts CK, Weymouth CW, Frawley MT
J Emerg Med 2020 Apr;58(4):616-619. Epub 2020 Mar 20 doi: 10.1016/j.jemermed.2019.12.031. PMID: 32204996

Botulinum A exotoxin for the management of platysma bands.

Matarasso A, Matarasso SL, Brandt FS, Bellman B
Plast Reconstr Surg 1999 Feb;103(2):645-52; discussion 653-5. doi: 10.1097/00006534-199902000-00043. PMID: 9950556

Driving under the influence of GHB?

Stephens BG, Baselt RC
J Anal Toxicol 1994 Oct;18(6):357-8. doi: 10.1093/jat/18.6.357. PMID: 7823545

Increased masticatory muscle stiffness during limb muscle flaccidity associated with succinylcholine administration.

Van der Spek AF, Fang WB, Ashton-Miller JA, Stohler CS, Carlson DS, Schork MA
Anesthesiology 1988 Jul;69(1):11-6. doi: 10.1097/00000542-198807000-00002. PMID: 3389546

Neomycin-induced neuromuscular blockade.

Coleman JW, Yao FY, Jalandoni SR, Artusio JF, McGovern JH
Urology 1981 Mar;17(3):265-7. doi: 10.1016/0090-4295(81)90045-5. PMID: 7010759

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