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Middle lobe syndrome

MedGen UID:
6393
•Concept ID:
C0026069
•
Disease or Syndrome
Synonyms: Brock Syndrome; Brock's Syndrome; Brocks Syndrome; Middle Lobe Syndrome; Syndrome, Brock's; Syndromes, Middle Lobe
SNOMED CT: Middle lobe syndrome (28295001); Brock syndrome (28295001)
 
Monarch Initiative: MONDO:0005847

Definition

Atelectasis of the right middle pulmonary lobe, with chronic pneumonitis. (Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle lobe syndrome

Professional guidelines

PubMed

Bronchoscopy for management and identification of etiology of right middle lobe syndrome: Analysis of 66 cases.
Freidkin L, Heching M, Rosengarten D, Pertzov B, Gershman E, Izhakian S, Amor SM, Kramer MR
Thorac Cancer 2023 Nov;14(32):3226-3231. Epub 2023 Sep 13 doi: 10.1111/1759-7714.15113. PMID: 37704575Free PMC Article
Ten years' experience in surgical treatment of right middle lobe syndrome.
Pejhan S, Salehi F, Niusha S, Farzanegan B, Sheikhy K
Ann Thorac Cardiovasc Surg 2015;21(4):354-8. Epub 2015 Mar 2 doi: 10.5761/atcs.oa.14-00273. PMID: 25753209Free PMC Article
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Gudbjartsson T, Gudmundsson G
Respiration 2012;84(1):80-6. Epub 2012 Mar 1 doi: 10.1159/000336238. PMID: 22377566

Recent clinical studies

Etiology

Case Report: Middle lobe syndrome: a rare presentation in eosinophilic granulomatosis with polyangiitis.
Maranini B, Guzzinati I, Casoni GL, Ballotta M, Lo Monaco A, Govoni M
Front Immunol 2023;14:1222431. Epub 2023 Aug 10 doi: 10.3389/fimmu.2023.1222431. PMID: 37638004Free PMC Article
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Secretory hyperresponsiveness and pulmonary mucus hypersecretion.
Rubin BK, Priftis KN, Schmidt HJ, Henke MO
Chest 2014 Aug;146(2):496-507. doi: 10.1378/chest.13-2609. PMID: 25091755
Middle lobe syndrome.
Gudmundsson G, Gross TJ
Am Fam Physician 1996 Jun;53(8):2547-50. PMID: 8644568
Middle lobe syndrome.
Wagner RB, Johnston MR
Ann Thorac Surg 1983 Jun;35(6):679-86. doi: 10.1016/s0003-4975(10)61085-5. PMID: 6344820

Diagnosis

Tuberculosis and Other Granulomatous Diseases of the Airway.
Santosham R, Deslauriers J
Thorac Surg Clin 2018 May;28(2):155-161. doi: 10.1016/j.thorsurg.2018.01.004. PMID: 29627049
Middle lobe syndrome in children today.
Romagnoli V, Priftis KN, de Benedictis FM
Paediatr Respir Rev 2014 Jun;15(2):188-93. Epub 2014 Jan 31 doi: 10.1016/j.prrv.2014.01.002. PMID: 24630779
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Gudbjartsson T, Gudmundsson G
Respiration 2012;84(1):80-6. Epub 2012 Mar 1 doi: 10.1159/000336238. PMID: 22377566
Middle lobe syndrome.
Gudmundsson G, Gross TJ
Am Fam Physician 1996 Jun;53(8):2547-50. PMID: 8644568
Middle lobe syndrome.
Wagner RB, Johnston MR
Ann Thorac Surg 1983 Jun;35(6):679-86. doi: 10.1016/s0003-4975(10)61085-5. PMID: 6344820

Therapy

Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Infectious Causes of Right Middle Lobe Syndrome.
Rashid A, Nanjappa S, Greene JN
Cancer Control 2017 Jan;24(1):60-65. doi: 10.1177/107327481702400110. PMID: 28178715
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.
Gudbjartsson T, Gudmundsson G
Respiration 2012;84(1):80-6. Epub 2012 Mar 1 doi: 10.1159/000336238. PMID: 22377566
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment.
Einarsson JT, Einarsson JG, Isaksson H, Gudbjartsson T, Gudmundsson G
Clin Respir J 2009 Apr;3(2):77-81. doi: 10.1111/j.1752-699X.2008.00109.x. PMID: 20298381
Atelectasis in childhood.
Redding GJ
Pediatr Clin North Am 1984 Aug;31(4):891-905. doi: 10.1016/s0031-3955(16)34652-1. PMID: 6462803

Prognosis

Case Report: Middle lobe syndrome: a rare presentation in eosinophilic granulomatosis with polyangiitis.
Maranini B, Guzzinati I, Casoni GL, Ballotta M, Lo Monaco A, Govoni M
Front Immunol 2023;14:1222431. Epub 2023 Aug 10 doi: 10.3389/fimmu.2023.1222431. PMID: 37638004Free PMC Article
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
Infectious Causes of Right Middle Lobe Syndrome.
Rashid A, Nanjappa S, Greene JN
Cancer Control 2017 Jan;24(1):60-65. doi: 10.1177/107327481702400110. PMID: 28178715
Ten years' experience in surgical treatment of right middle lobe syndrome.
Pejhan S, Salehi F, Niusha S, Farzanegan B, Sheikhy K
Ann Thorac Cardiovasc Surg 2015;21(4):354-8. Epub 2015 Mar 2 doi: 10.5761/atcs.oa.14-00273. PMID: 25753209Free PMC Article
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment.
Einarsson JT, Einarsson JG, Isaksson H, Gudbjartsson T, Gudmundsson G
Clin Respir J 2009 Apr;3(2):77-81. doi: 10.1111/j.1752-699X.2008.00109.x. PMID: 20298381

Clinical prediction guides

Middle lobe syndrome revealing Broncholithiasis: A Case Report.
Abid N, Loukil M, Gader N, Chaabane A, Bouzaidi K, Ghrairi H
Tunis Med 2023 Apr 5;101(4):460-462. PMID: 38372529Free PMC Article
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle.
Strollo DC, Donnenberg VS, Madan S, Moran PL, Luketich JD, Sanchez MV
Asian Cardiovasc Thorac Ann 2023 Mar;31(3):215-220. Epub 2022 Dec 13 doi: 10.1177/02184923221144402. PMID: 36514840Free PMC Article
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome.
Li J, Liu C, Zhao Y, Li C, Liu L
World J Surg 2017 Mar;41(3):780-784. doi: 10.1007/s00268-016-3777-6. PMID: 27807707Free PMC Article
Chronic atelectasis of the left lower lobe: a clinicopathological condition equivalent to middle lobe syndrome.
Hamad AM, Elmistekawy E, Elatafy E
Interact Cardiovasc Thorac Surg 2012 Oct;15(4):618-21. Epub 2012 Jul 2 doi: 10.1093/icvts/ivs305. PMID: 22761114Free PMC Article
Outcome after right middle lobe syndrome.
De Boeck K, Willems T, Van Gysel D, Corbeel L, Eeckels R
Chest 1995 Jul;108(1):150-2. doi: 10.1378/chest.108.1.150. PMID: 7606950

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