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Mesenchymoma

MedGen UID:
7553
•Concept ID:
C0025464
•
Neoplastic Process
Synonym: Mesenchymomas
SNOMED CT: Mesenchymomas (44524009); Mesenchymoma (44524009); Mixed mesenchymal tumor (44524009)
 
Monarch Initiative: MONDO:0006854

Definition

A term describing a soft tissue tumor which consists of two or more mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. [from NCI]

Professional guidelines

PubMed

Childhood hepatic mesenchymoma: successful treatment with surgery and multiple-agent chemotherapy.
Ware R, Friedman HS, Filston HC, Chaffee S, Kurtzberg J, Kinney TR, Falletta JM
Med Pediatr Oncol 1988;16(1):62-5. doi: 10.1002/mpo.2950160114. PMID: 3340065
Iridium afterloading curietherapy in the treatment of pediatric malignancies. The Institut Gustave Roussy experience.
Gerbaulet A, Panis X, Flamant F, Chassagne D
Cancer 1985 Sep 15;56(6):1274-9. doi: 10.1002/1097-0142(19850915)56:6<1274::aid-cncr2820560609>3.0.co;2-8. PMID: 4027867
Thirty years of experience with pediatric primary malignant liver tumors.
Giacomantonio M, Ein SH, Mancer K, Stephens CA
J Pediatr Surg 1984 Oct;19(5):523-6. doi: 10.1016/s0022-3468(84)80095-0. PMID: 6094781

Recent clinical studies

Etiology

Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia.
Abate V, Vergatti A, De Filippo G, Damiano V, Menale C, D'Elia L, Rendina D
J Clin Endocrinol Metab 2024 Feb 20;109(3):e1006-e1011. doi: 10.1210/clinem/dgad690. PMID: 38006315
New advances in the molecular classification of pediatric mesenchymal tumors.
Suurmeijer AJH, Kao YC, Antonescu CR
Genes Chromosomes Cancer 2019 Feb;58(2):100-110. Epub 2018 Oct 11 doi: 10.1002/gcc.22681. PMID: 30187985Free PMC Article
Tumor-Induced Osteomalacia: an Up-to-Date Review.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M
Curr Rheumatol Rep 2015 Jun;17(6):512. doi: 10.1007/s11926-015-0512-5. PMID: 25900190
Uterine mesenchymal tumors.
Sangle NA, Lele SM
Indian J Pathol Microbiol 2011 Apr-Jun;54(2):243-53. doi: 10.4103/0377-4929.81582. PMID: 21623068
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Tumor-induced osteomalacia: An overview.
Jadhav SS, Shah R, Patil V
Best Pract Res Clin Endocrinol Metab 2024 Mar;38(2):101834. Epub 2023 Oct 20 doi: 10.1016/j.beem.2023.101834. PMID: 37935612
Phosphaturic Mesenchymal Tumor.
Benson JC, Trejo-Lopez JA, Nassiri AM, Eschbacher K, Link MJ, Driscoll CL, Tiegs RD, Sfeir J, DeLone DR
AJNR Am J Neuroradiol 2022 Jun;43(6):817-822. Epub 2022 May 19 doi: 10.3174/ajnr.A7513. PMID: 35589138Free PMC Article
Tumor-Induced Osteomalacia: an Up-to-Date Review.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M
Curr Rheumatol Rep 2015 Jun;17(6):512. doi: 10.1007/s11926-015-0512-5. PMID: 25900190
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601
Malignant mesenchymoma.
Brady MS, Perino G, Tallini G, Russo P, Woodruff JM
Cancer 1996 Feb 1;77(3):467-73. doi: 10.1002/(SICI)1097-0142(19960201)77:3<467::AID-CNCR7>3.0.CO;2-H. PMID: 8630953

Therapy

The Game Is Afoot.
Yozamp N, Hornick JL, Chiodo CP, Miller AL, Loscalzo J
N Engl J Med 2020 Jun 4;382(23):2249-2255. doi: 10.1056/NEJMcps1913599. PMID: 32492308
The Game Is Afoot.
Yozamp N, Charles J, Shah H, Vaidya A, Pallais JC
N Engl J Med 2020 May 28;382(22):e78. doi: 10.1056/NEJMimc1914302. PMID: 32459927
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
Mrad K, Sassi S, Smida M, Oubiche F, Mekni A, Romdhane KB
Pathologica 2004 Dec;96(6):475-8. PMID: 15792374
Steroid hormone-producing tumors in man.
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606
Sarcoma botryoides.
Rutledge F, Sullivan MP
Ann N Y Acad Sci 1967 May 10;142(3):694-708. doi: 10.1111/j.1749-6632.1967.tb14680.x. PMID: 5231254

Prognosis

Prognostication in Mesenchymal Tumors: Can We Improve?
Wang WL
Surg Pathol Clin 2019 Mar;12(1):217-225. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.009. PMID: 30709445
New advances in the molecular classification of pediatric mesenchymal tumors.
Suurmeijer AJH, Kao YC, Antonescu CR
Genes Chromosomes Cancer 2019 Feb;58(2):100-110. Epub 2018 Oct 11 doi: 10.1002/gcc.22681. PMID: 30187985Free PMC Article
Tumor-Induced Osteomalacia: an Up-to-Date Review.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M
Curr Rheumatol Rep 2015 Jun;17(6):512. doi: 10.1007/s11926-015-0512-5. PMID: 25900190
Malignant mesenchymoma.
Brady MS, Perino G, Tallini G, Russo P, Woodruff JM
Cancer 1996 Feb 1;77(3):467-73. doi: 10.1002/(SICI)1097-0142(19960201)77:3<467::AID-CNCR7>3.0.CO;2-H. PMID: 8630953
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

Clinical prediction guides

Prognostication in Mesenchymal Tumors: Can We Improve?
Wang WL
Surg Pathol Clin 2019 Mar;12(1):217-225. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.009. PMID: 30709445
Desmoid tumor: from surgical extirpation to molecular dissection.
Lazar AJ, Hajibashi S, Lev D
Curr Opin Oncol 2009 Jul;21(4):352-9. doi: 10.1097/CCO.0b013e32832c9502. PMID: 19436199
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
Mrad K, Sassi S, Smida M, Oubiche F, Mekni A, Romdhane KB
Pathologica 2004 Dec;96(6):475-8. PMID: 15792374
"Mesenchymal tumor" or "decidual-like reaction"?
Karbe E
Toxicol Pathol 1999 May-Jun;27(3):354-62. doi: 10.1177/019262339902700312. PMID: 10356713
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

Recent systematic reviews

Intracranial Phosphaturic Mesenchymal Tumors: A Systematic Literature Review of a Rare Entity.
Sánchez Muñoz R, Sanmillan JL, Vidal Sarró N, Martín Quintero G, Martí Duce D, Gabarrós Canals A
World Neurosurg 2024 Jul;187:70-81. Epub 2024 Mar 30 doi: 10.1016/j.wneu.2024.03.138. PMID: 38561034
Treatment and Diagnose of Spinal Phosphaturic Mesenchymal Tumor: A Case Report and a Systematic Literature Review.
Chen D, Zhang L, Zhang J, Yin M, Gao X, Huang Q, Li L, Yang X
World Neurosurg 2024 Apr;184:65-73. Epub 2024 Jan 12 doi: 10.1016/j.wneu.2024.01.032. PMID: 38218444
Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia.
Abate V, Vergatti A, De Filippo G, Damiano V, Menale C, D'Elia L, Rendina D
J Clin Endocrinol Metab 2024 Feb 20;109(3):e1006-e1011. doi: 10.1210/clinem/dgad690. PMID: 38006315
A Systematic Review of Nasal Chondromesenchymal Hamartoma (NCMH) with a New Case Report.
Javadirad E, Azimivaghar J, Montazer S, Sharafi S
Head Neck Pathol 2022 Dec;16(4):1172-1184. Epub 2022 May 4 doi: 10.1007/s12105-022-01452-7. PMID: 35507301Free PMC Article
Clinical features of ectomesenchymal chondromyxoid tumors: A systematic review of the literature.
Kato MG, Erkul E, Brewer KS, Harruff EE, Nguyen SA, Day TA
Oral Oncol 2017 Apr;67:192-197. Epub 2017 Mar 8 doi: 10.1016/j.oraloncology.2017.02.021. PMID: 28351576

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