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Menopausal syndrome

MedGen UID:
9962
•Concept ID:
C0025319
•
Disease or Syndrome
Synonym: Menopausal Syndrome
SNOMED CT: Menopausal syndrome (123756000)

Definition

A grouping of variable physical, vasomotor and psychological symptoms in climacteric females. Physical symptoms include: cessation of menses, headaches, fatigue, weight gain and vaginal dryness. Vasomotor symptoms typically include: palpitations, hot flashes and night sweats. Psychological symptoms may include: decrease in libido, emotional lability, difficulty concentrating and insomnia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMenopausal syndrome

Professional guidelines

PubMed

The treatment of menopausal symptoms by traditional Chinese medicine in Asian countries.
Wang YP, Yu Q
Climacteric 2021 Feb;24(1):64-67. Epub 2020 Oct 23 doi: 10.1080/13697137.2020.1832461. PMID: 33094658
Clinical efficacy of add-back therapy in treatment of endometriosis: a meta-analysis.
Wu D, Hu M, Hong L, Hong S, Ding W, Min J, Fang G, Guo W
Arch Gynecol Obstet 2014 Sep;290(3):513-23. Epub 2014 Apr 13 doi: 10.1007/s00404-014-3230-8. PMID: 24728145
Phytoestrogens in the management of the menopause: up-to-date.
Ewies AA
Obstet Gynecol Surv 2002 May;57(5):306-13. doi: 10.1097/00006254-200205000-00023. PMID: 11997677

Recent clinical studies

Etiology

D-Pinitol attenuates postmenopausal symptoms in ovariectomized mice.
Kang WC, Park K, Kong CH, Kim DY, Lee YS, Jeon M, Kim MS, Jung SY, Hong J, Choi JH, Ryu JH
Life Sci 2023 Nov 15;333:122147. Epub 2023 Oct 5 doi: 10.1016/j.lfs.2023.122147. PMID: 37802198
The Role of Hormonal Replacement Therapy in BRCA Mutated Patients: Lights and Shadows.
Loizzi V, Dellino M, Cerbone M, Arezzo F, Cazzato G, Damiani GR, Pinto V, Silvestris E, Kardhashi A, Cicinelli E, Cascardi E, Cormio G
Int J Mol Sci 2023 Jan 1;24(1) doi: 10.3390/ijms24010764. PMID: 36614207Free PMC Article
The relationship between menopausal syndrome and gut microbes.
Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y
BMC Womens Health 2022 Nov 8;22(1):437. doi: 10.1186/s12905-022-02029-w. PMID: 36348390Free PMC Article
Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview.
Chen LR, Chen KH
Int J Mol Sci 2021 Mar 22;22(6) doi: 10.3390/ijms22063212. PMID: 33809928Free PMC Article
A universal menopausal syndrome?
Avis NE, Brockwell S, Colvin A
Am J Med 2005 Dec 19;118 Suppl 12B:37-46. doi: 10.1016/j.amjmed.2005.09.057. PMID: 16414325

Diagnosis

Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism.
Hu S, Ding Q, Zhang W, Kang M, Ma J, Zhao L
Gut Microbes 2023 Jan-Dec;15(1):2236749. doi: 10.1080/19490976.2023.2236749. PMID: 37559394Free PMC Article
Association of Menopausal Symptoms with Different Constitutions in Climacteric Women.
Wu HC, Chen KH, Hwang JS
Complement Med Res 2018;25(6):398-405. Epub 2018 Aug 28 doi: 10.1159/000491389. PMID: 30153672
Chinese medicine for menopausal syndrome: current status, problems and strategies.
Wang XY, Nie GN, Yang HY, Zong LL
Chin J Integr Med 2011 Dec;17(12):889-92. Epub 2011 Dec 3 doi: 10.1007/s11655-011-0931-8. PMID: 22139539
Oestrogen therapy and the menopausal syndrome.
Campbell S, Whitehead M
Clin Obstet Gynaecol 1977 Apr;4(1):31-47. PMID: 322905
The pill and the breast.
Leis HP, Black MM, Sall S
J Reprod Med 1976 Jan;16(1):5-9. PMID: 1255643

Therapy

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis.
Mohapatra S, Kumar PA, Aggarwal A, Iqubal A, Mirza MA, Iqbal Z
Phytother Res 2024 Jun;38(6):2728-2763. Epub 2024 Mar 24 doi: 10.1002/ptr.8172. PMID: 38522005
D-Pinitol attenuates postmenopausal symptoms in ovariectomized mice.
Kang WC, Park K, Kong CH, Kim DY, Lee YS, Jeon M, Kim MS, Jung SY, Hong J, Choi JH, Ryu JH
Life Sci 2023 Nov 15;333:122147. Epub 2023 Oct 5 doi: 10.1016/j.lfs.2023.122147. PMID: 37802198
The Role of Hormonal Replacement Therapy in BRCA Mutated Patients: Lights and Shadows.
Loizzi V, Dellino M, Cerbone M, Arezzo F, Cazzato G, Damiani GR, Pinto V, Silvestris E, Kardhashi A, Cicinelli E, Cascardi E, Cormio G
Int J Mol Sci 2023 Jan 1;24(1) doi: 10.3390/ijms24010764. PMID: 36614207Free PMC Article
Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview.
Chen LR, Chen KH
Int J Mol Sci 2021 Mar 22;22(6) doi: 10.3390/ijms22063212. PMID: 33809928Free PMC Article
The treatment of menopausal symptoms by traditional Chinese medicine in Asian countries.
Wang YP, Yu Q
Climacteric 2021 Feb;24(1):64-67. Epub 2020 Oct 23 doi: 10.1080/13697137.2020.1832461. PMID: 33094658

Prognosis

New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome.
Song X, Shen L, Contreras JM, Liu Z, Ma K, Ma B, Liu X, Wang DO
Phytother Res 2024 Sep;38(9):4736-4756. Epub 2024 Aug 9 doi: 10.1002/ptr.8289. PMID: 39120263
The 100 top-cited articles in menopausal syndrome: a bibliometric analysis.
Jin Z, Tian C, Kang M, Hu S, Zhao L, Zhang W
Reprod Health 2024 Apr 8;21(1):47. doi: 10.1186/s12978-024-01770-9. PMID: 38589898Free PMC Article
The relationship between menopausal syndrome and gut microbes.
Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y
BMC Womens Health 2022 Nov 8;22(1):437. doi: 10.1186/s12905-022-02029-w. PMID: 36348390Free PMC Article
Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome.
Zhang Q, Liang J, Zhou Y
Medicine (Baltimore) 2022 Jul 22;101(29):e29453. doi: 10.1097/MD.0000000000029453. PMID: 35866834Free PMC Article
Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women.
Zheng TP, Sun AJ, Xue W, Wang YP, Jiang Y, Zhang Y, Lang JH
Chin Med J (Engl) 2013;126(11):2034-8. PMID: 23769553

Clinical prediction guides

The 100 top-cited articles in menopausal syndrome: a bibliometric analysis.
Jin Z, Tian C, Kang M, Hu S, Zhao L, Zhang W
Reprod Health 2024 Apr 8;21(1):47. doi: 10.1186/s12978-024-01770-9. PMID: 38589898Free PMC Article
Combined Bazedoxifene and Genistein Ameliorate Ovariectomy-Induced Hippocampal Neuro-Alterations via Activating CREB/BDNF/TrkB Signaling Pathway.
Samak MA, Abdelrahman AA, Samy W, Abdelrahman SA
Curr Mol Pharmacol 2023;16(6):664-681. doi: 10.2174/1874467215666220902112939. PMID: 36056862
The relationship between menopausal syndrome and gut microbes.
Liu Y, Zhou Y, Mao T, Huang Y, Liang J, Zhu M, Yao P, Zong Y, Lang J, Zhang Y
BMC Womens Health 2022 Nov 8;22(1):437. doi: 10.1186/s12905-022-02029-w. PMID: 36348390Free PMC Article
Association Between Parity and the Age at Menopause and Menopausal Syndrome in Northwest China.
Sun X, Zhang R, Wang L, Shen X, Lu Y, An J, Wang L, Wang Y, Luo X, Zhu H, Zhang X
Asia Pac J Public Health 2021 Jan;33(1):60-66. Epub 2020 Sep 25 doi: 10.1177/1010539520960987. PMID: 32975428
Menopausal syndrome limited to hot flushes and sweating a representative survey study.
Weidner K, Croy I, Siepmann T, Brähler E, Beutel M, Bittner A
J Psychosom Obstet Gynaecol 2017 Sep;38(3):170-179. Epub 2017 Mar 29 doi: 10.1080/0167482X.2017.1291624. PMID: 28351196

Recent systematic reviews

Efficacy and Safety of Acupuncture Vs. Hormone Therapy for Menopausal Syndrome: A Systematic Review and Meta-Analysis.
He QD, Zhong ZH, Liu MN, Tong ZY, Wu QB, Chen M
Am J Chin Med 2021;49(8):1793-1812. Epub 2021 Nov 12 doi: 10.1142/S0192415X21500853. PMID: 34772331
Erxian decoction, a Chinese herbal formula, for menopausal syndrome: An updated systematic review.
Wang Y, Lou XT, Shi YH, Tong Q, Zheng GQ
J Ethnopharmacol 2019 Apr 24;234:8-20. Epub 2019 Jan 15 doi: 10.1016/j.jep.2019.01.010. PMID: 30658181
Chinese herbal medicine Kuntai capsule for treatment of menopausal syndrome: a systematic review of randomized clinical trials.
Zhou Q, Tao J, Song H, Chen A, Yang H, Zuo M, Li H
Complement Ther Med 2016 Dec;29:63-71. Epub 2016 Sep 13 doi: 10.1016/j.ctim.2016.09.011. PMID: 27912959
Systematic review and meta-analysis of randomized controlled trials on Wenxin keli.
Wang X, Wang Y, Feng X, Lu Y, Zhang Y, Wang W, Zhu W
Drug Des Devel Ther 2016;10:3725-3736. Epub 2016 Nov 14 doi: 10.2147/DDDT.S112333. PMID: 27881911Free PMC Article

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