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Pneumococcal meningitis

MedGen UID:
44354
Concept ID:
C0025295
Disease or Syndrome
Synonyms: Meningitides, Streptococcus pneumoniae; Meningitis, Pneumococcal; Meningitis, Streptococcus pneumoniae; Pneumococcal Meningitides; Pneumococcal Meningitis; Streptococcus pneumoniae Meningitides; Streptococcus pneumoniae Meningitis
SNOMED CT: Pneumococcal meningitis (51169003)
 
Monarch Initiative: MONDO:0006913
Orphanet: ORPHA55655

Definition

A rare infectious disease of the nervous system caused by the bacterium Streptococcus pneumoniae, which is commonly part of the bacterial flora colonizing the nasopharyngeal mucosa. The disease is clinically characterized by typical symptoms of acute leptomeningitis, like fever, headache, neck stiffness, vomiting, and clouding of consciousness. It is frequently fatal and, in surviving patients, often accompanied by long-term sequelae, especially focal neurological deficits, hearing loss, cognitive impairment, and epilepsy. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPneumococcal meningitis
Follow this link to review classifications for Pneumococcal meningitis in Orphanet.

Professional guidelines

PubMed

Xu Y, Wang J, Qin X, Liu J
Virulence 2024 Dec;15(1):2387180. Epub 2024 Aug 27 doi: 10.1080/21505594.2024.2387180. PMID: 39192572Free PMC Article
Gillet Y, Grimprel E, Haas H, Yaghy M, Dubos F, Cohen R
Infect Dis Now 2023 Nov;53(8S):104788. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104788. PMID: 37741342
Young N, Thomas M
Intern Med J 2018 Nov;48(11):1294-1307. doi: 10.1111/imj.14102. PMID: 30387309

Recent clinical studies

Etiology

Gillet Y, Grimprel E, Haas H, Yaghy M, Dubos F, Cohen R
Infect Dis Now 2023 Nov;53(8S):104788. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104788. PMID: 37741342
Young N, Thomas M
Intern Med J 2018 Nov;48(11):1294-1307. doi: 10.1111/imj.14102. PMID: 30387309
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658
van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2016 May;22 Suppl 3:S37-62. Epub 2016 Apr 7 doi: 10.1016/j.cmi.2016.01.007. PMID: 27062097
de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
N Engl J Med 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. PMID: 12432041

Diagnosis

Xu Y, Wang J, Qin X, Liu J
Virulence 2024 Dec;15(1):2387180. Epub 2024 Aug 27 doi: 10.1080/21505594.2024.2387180. PMID: 39192572Free PMC Article
Siegel JL
Neurol Neurochir Pol 2019;53(4):242-250. Epub 2019 Aug 23 doi: 10.5603/PJNNS.a2019.0032. PMID: 31441497
Young N, Thomas M
Intern Med J 2018 Nov;48(11):1294-1307. doi: 10.1111/imj.14102. PMID: 30387309
Swanson D
Pediatr Rev 2015 Dec;36(12):514-24; quiz 525-6. doi: 10.1542/pir.36-12-514. PMID: 26628732
Heckenberg SG, Brouwer MC, van de Beek D
Handb Clin Neurol 2014;121:1361-75. doi: 10.1016/B978-0-7020-4088-7.00093-6. PMID: 24365425

Therapy

Gillet Y, Grimprel E, Haas H, Yaghy M, Dubos F, Cohen R
Infect Dis Now 2023 Nov;53(8S):104788. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104788. PMID: 37741342
Young N, Thomas M
Intern Med J 2018 Nov;48(11):1294-1307. doi: 10.1111/imj.14102. PMID: 30387309
Swanson D
Pediatr Rev 2015 Dec;36(12):514-24; quiz 525-6. doi: 10.1542/pir.36-12-514. PMID: 26628732
de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
N Engl J Med 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. PMID: 12432041
Edwards DA, Hahn AL
Nebr Med J 1973 Nov;58(11):399-400. PMID: 4271187

Prognosis

Teske NC, Dyckhoff-Shen S, Beckenbauer P, Bewersdorf JP, Engelen-Lee JY, Hammerschmidt S, Kälin RE, Pfister HW, Brouwer MC, Klein M, Glass R, van de Beek D, Koedel U
J Neuroinflammation 2023 Nov 17;20(1):267. doi: 10.1186/s12974-023-02938-z. PMID: 37978545Free PMC Article
Koelman DLH, Brouwer MC, van de Beek D
Clin Microbiol Infect 2020 Feb;26(2):199-204. Epub 2019 May 14 doi: 10.1016/j.cmi.2019.04.032. PMID: 31100424
Siegel JL
Neurol Neurochir Pol 2019;53(4):242-250. Epub 2019 Aug 23 doi: 10.5603/PJNNS.a2019.0032. PMID: 31441497
Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658

Clinical prediction guides

Teske NC, Dyckhoff-Shen S, Beckenbauer P, Bewersdorf JP, Engelen-Lee JY, Hammerschmidt S, Kälin RE, Pfister HW, Brouwer MC, Klein M, Glass R, van de Beek D, Koedel U
J Neuroinflammation 2023 Nov 17;20(1):267. doi: 10.1186/s12974-023-02938-z. PMID: 37978545Free PMC Article
Gillet Y, Grimprel E, Haas H, Yaghy M, Dubos F, Cohen R
Infect Dis Now 2023 Nov;53(8S):104788. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104788. PMID: 37741342
Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M
N Engl J Med 2004 Oct 28;351(18):1849-59. doi: 10.1056/NEJMoa040845. PMID: 15509818
de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
N Engl J Med 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. PMID: 12432041

Recent systematic reviews

Someko H, Okazaki Y, Tsujimoto Y, Ishikane M, Kubo K, Kakehashi T
Clin Microbiol Infect 2023 Mar;29(3):310-319. Epub 2022 Dec 8 doi: 10.1016/j.cmi.2022.12.002. PMID: 36503113
Britt AF, Poupore NS, Nguyen SA, White DR
Otolaryngol Head Neck Surg 2023 Mar;168(3):291-299. Epub 2023 Jan 29 doi: 10.1177/01945998221113310. PMID: 35852861
Franklin K, Kwambana-Adams B, Lessa FC, Soeters HM, Cooper L, Coldiron ME, Mwenda J, Antonio M, Nakamura T, Novak R, Cohen AL
J Infect Dis 2021 Sep 1;224(12 Suppl 2):S174-S183. doi: 10.1093/infdis/jiab105. PMID: 34469561Free PMC Article
Bijlsma MW, Brouwer MC, Bossuyt PM, Heymans MW, van der Ende A, Tanck MW, van de Beek D
J Infect 2016 Nov;73(5):393-401. Epub 2016 Aug 9 doi: 10.1016/j.jinf.2016.08.003. PMID: 27519619
Ciapponi A, Elorriaga N, Rojas JI, Romano M, Martí SG, Bardach A, Ruvinsky S
Pediatr Infect Dis J 2014 Sep;33(9):971-8. doi: 10.1097/INF.0000000000000363. PMID: 24830699

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