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Meningococcal meningitis

MedGen UID:
6299
Concept ID:
C0025294
Disease or Syndrome
Synonyms: Meningitis, Meningococcal; Meningitis, Meningococcic; Meningitis, Neisseria; Meningococcal Meningitis; Neisseria Meningitides; Neisseria Meningitis
SNOMED CT: Epidemic meningitis (192644005); Meningococcal meningitis (192644005); Meningococcal cerebrospinal fever (192644005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018059
Orphanet: ORPHA33475

Definition

Meningococcal meningitis is an acute bacterial disease caused by <i>Neisseria meningitides</i> that presents usually, but not always, with a rash (non blanching petechial or purpuric rash), progressively developing signs of meningitis (fever, vomiting, headache, photophobia, and neck stiffness) and later leading to confusion, delirium and drowsiness. Neck stiffness and photophobia are often absent in infants and young children who may manifest nonspecific signs such as irritability, inconsolable crying, poor feeding, and a bulging fontanel. Meningococcal meningitis may also present as part of early or late onset sepsis in neonates. The disease is potentially fatal. Surviving patients may develop neurological sequelae that include sensorineural hearing loss, seizures, spasticity, attention deficits and intellectual disability. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningococcal meningitis
Follow this link to review classifications for Meningococcal meningitis in Orphanet.

Professional guidelines

PubMed

Cohen R, Raymond J, Hees L, Pinquier D, Grimprel E, Levy C
Arch Pediatr 2017 Dec;24(12S):S42-S45. doi: 10.1016/S0929-693X(17)30518-3. PMID: 29290234
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Recent clinical studies

Therapy

Aljohani S, Hussein WM, Toth I, Simerska P
Curr Drug Deliv 2019;16(7):609-617. doi: 10.2174/1567201816666190702153612. PMID: 31267872
Burnett MW
J Spec Oper Med 2017 Spring;17(1):90-92. doi: 10.55460/URE1-Z992. PMID: 28285486
Stephens DS
FEMS Microbiol Rev 2007 Jan;31(1):3-14. doi: 10.1111/j.1574-6976.2006.00051.x. PMID: 17233633
Bethell D, Pollard AJ
Expert Rev Vaccines 2002 Jun;1(1):75-84. doi: 10.1586/14760584.1.1.75. PMID: 12908514
Lancet 1989 Mar 25;1(8639):647-8. PMID: 2564462

Prognosis

Asturias EJ, Bai X, Bettinger JA, Borrow R, Castillo DN, Caugant DA, Chacon GC, Dinleyici EC, Echaniz-Aviles G, Garcia L, Glennie L, Harrison LH, Howie RL, Itsko M, Lucidarme J, Marin JEO, Marjuki H, McNamara LA, Mustapha MM, Robinson JL, Romeu B, Sadarangani M, Sáez-Llorens X, Sáfadi MAP, Stephens DS, Stuart JM, Taha MK, Tsang RSW, Vazquez J, De Wals P
J Infect 2022 Dec;85(6):611-622. Epub 2022 Oct 20 doi: 10.1016/j.jinf.2022.10.022. PMID: 36273639Free PMC Article
Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D
Lancet Infect Dis 2016 Mar;16(3):339-47. Epub 2015 Dec 1 doi: 10.1016/S1473-3099(15)00430-2. PMID: 26652862
The Lancet
Lancet 2013 Aug 3;382(9890):368. doi: 10.1016/S0140-6736(13)61656-6. PMID: 23911364
Ebrahim GJ
J Trop Pediatr 1997 Jun;43(3):126-7. doi: 10.1093/tropej/43.3.126. PMID: 9231629

Clinical prediction guides

Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
Salmon-Rousseau A, Piednoir E, Cattoir V, de La Blanchardière A
Med Mal Infect 2016 Oct;46(7):346-354. Epub 2016 May 24 doi: 10.1016/j.medmal.2016.04.002. PMID: 27230822Free PMC Article
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D
Lancet Infect Dis 2016 Mar;16(3):339-47. Epub 2015 Dec 1 doi: 10.1016/S1473-3099(15)00430-2. PMID: 26652862
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M
N Engl J Med 2004 Oct 28;351(18):1849-59. doi: 10.1056/NEJMoa040845. PMID: 15509818
de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
N Engl J Med 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. PMID: 12432041

Recent systematic reviews

Rostamian M, Chegene Lorestani R, Jafari S, Mansouri R, Rezaeian S, Ghadiri K, Akya A
Indian J Med Microbiol 2022 Jul-Sep;40(3):323-329. Epub 2022 May 30 doi: 10.1016/j.ijmmb.2022.05.005. PMID: 35654713
Franklin K, Kwambana-Adams B, Lessa FC, Soeters HM, Cooper L, Coldiron ME, Mwenda J, Antonio M, Nakamura T, Novak R, Cohen AL
J Infect Dis 2021 Sep 1;224(12 Suppl 2):S174-S183. doi: 10.1093/infdis/jiab105. PMID: 34469561Free PMC Article
Sudarsanam TD, Rupali P, Tharyan P, Abraham OC, Thomas K
Cochrane Database Syst Rev 2017 Jun 14;6(6):CD005437. doi: 10.1002/14651858.CD005437.pub4. PMID: 28613408Free PMC Article
Bijlsma MW, Brouwer MC, Bossuyt PM, Heymans MW, van der Ende A, Tanck MW, van de Beek D
J Infect 2016 Nov;73(5):393-401. Epub 2016 Aug 9 doi: 10.1016/j.jinf.2016.08.003. PMID: 27519619
Dastouri F, Hosseini AM, Haworth E, Khandaker G, Rashid H, Booy R
Infect Disord Drug Targets 2014;14(3):205-12. doi: 10.2174/1871526515999150320155614. PMID: 25809622

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