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Melioidosis

MedGen UID:
44346
•Concept ID:
C0025229
•
Disease or Syndrome
Synonyms: Burkholderia pseudomallei Infection; Burkholderia pseudomallei Infections; Disease, Whitmore's; Infection, Burkholderia pseudomallei; Melioidoses; Whitmore Disease; Whitmore's Disease
SNOMED CT: Infection due to Burkholderia pseudomallei (428111003); Infection due to Whitmore's bacillus (428111003); Infection due to Pseudomonas pseudomallei (428111003); Melioidosis (428111003); Whitmore's disease (428111003); Infection due to Malleomyces pseudomallei (428111003)
 
Monarch Initiative: MONDO:0017775
Orphanet: ORPHA31202

Definition

A rare infectious disease caused by the Gram-negative bacillus <i>Burkholderia</i> (<i>pseudomonas</i>) <i>pseudomallei</i>, also called Whitmore bacillus. The infection can be acute, subacute, or chronic and affects the skin, the lungs, or the whole body. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelioidosis
Follow this link to review classifications for Melioidosis in Orphanet.

Professional guidelines

PubMed

Melioidosis and Burkholderia pseudomallei : progress in epidemiology, diagnosis, treatment and vaccination.
Currie BJ
Curr Opin Infect Dis 2022 Dec 1;35(6):517-523. Epub 2022 Aug 3 doi: 10.1097/QCO.0000000000000869. PMID: 35942848
Treatment and prophylaxis of melioidosis.
Dance D
Int J Antimicrob Agents 2014 Apr;43(4):310-8. Epub 2014 Feb 3 doi: 10.1016/j.ijantimicag.2014.01.005. PMID: 24613038Free PMC Article
Management of melioidosis.
Wuthiekanun V, Peacock SJ
Expert Rev Anti Infect Ther 2006 Jun;4(3):445-55. doi: 10.1586/14787210.4.3.445. PMID: 16771621

Recent clinical studies

Etiology

Travel-associated melioidosis: a narrative review.
Norman FF, Chen LH
J Travel Med 2023 May 18;30(3) doi: 10.1093/jtm/taad039. PMID: 36971472
Human Melioidosis.
Gassiep I, Armstrong M, Norton R
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Mar 11 doi: 10.1128/CMR.00006-19. PMID: 32161067Free PMC Article
Melioidosis: An updated review.
Chakravorty A, Heath CH
Aust J Gen Pract 2019 May;48(5):327-332. doi: 10.31128/AJGP-04-18-4558. PMID: 31129946
Melioidosis.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Melioidosis.
Peacock SJ
Curr Opin Infect Dis 2006 Oct;19(5):421-8. doi: 10.1097/01.qco.0000244046.31135.b3. PMID: 16940864

Diagnosis

Burkholderia pseudomallei and melioidosis.
Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ
Nat Rev Microbiol 2024 Mar;22(3):155-169. Epub 2023 Oct 4 doi: 10.1038/s41579-023-00972-5. PMID: 37794173
Melioidosis and Burkholderia pseudomallei : progress in epidemiology, diagnosis, treatment and vaccination.
Currie BJ
Curr Opin Infect Dis 2022 Dec 1;35(6):517-523. Epub 2022 Aug 3 doi: 10.1097/QCO.0000000000000869. PMID: 35942848
Melioidosis.
Anonymous A
J Spec Oper Med 2021 Winter;21(4):104-105. doi: 10.55460/WEJ5-A5CA. PMID: 34969137
Human Melioidosis.
Gassiep I, Armstrong M, Norton R
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Mar 11 doi: 10.1128/CMR.00006-19. PMID: 32161067Free PMC Article
Melioidosis: An updated review.
Chakravorty A, Heath CH
Aust J Gen Pract 2019 May;48(5):327-332. doi: 10.31128/AJGP-04-18-4558. PMID: 31129946

Therapy

Paediatric melioidosis.
Jarrett O, Seng S, Fitzgerald DA
Paediatr Respir Rev 2024 Jun;50:31-37. Epub 2023 Nov 24 doi: 10.1016/j.prrv.2023.11.002. PMID: 38245464
Melioidosis: clinical aspects.
Karunanayake P
Clin Med (Lond) 2022 Jan;22(1):6-8. doi: 10.7861/clinmed.2022-0014. PMID: 35078788Free PMC Article
Human Melioidosis.
Gassiep I, Armstrong M, Norton R
Clin Microbiol Rev 2020 Mar 18;33(2) Epub 2020 Mar 11 doi: 10.1128/CMR.00006-19. PMID: 32161067Free PMC Article
Melioidosis: An updated review.
Chakravorty A, Heath CH
Aust J Gen Pract 2019 May;48(5):327-332. doi: 10.31128/AJGP-04-18-4558. PMID: 31129946
Melioidosis.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article

Prognosis

Burkholderia pseudomallei and melioidosis.
Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ
Nat Rev Microbiol 2024 Mar;22(3):155-169. Epub 2023 Oct 4 doi: 10.1038/s41579-023-00972-5. PMID: 37794173
Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections.
Medhasi S, Chantratita N
J Immunol Res 2022;2022:9710376. Epub 2022 May 26 doi: 10.1155/2022/9710376. PMID: 35664353Free PMC Article
The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity.
Liu N, Pang X, Zhang H, Ji P
Front Immunol 2021;12:814709. Epub 2022 Jan 13 doi: 10.3389/fimmu.2021.814709. PMID: 35095914Free PMC Article
Melioidosis.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D
Nat Rev Dis Primers 2018 Feb 1;4:17107. doi: 10.1038/nrdp.2017.107. PMID: 29388572Free PMC Article
Melioidosis.
Peacock SJ
Curr Opin Infect Dis 2006 Oct;19(5):421-8. doi: 10.1097/01.qco.0000244046.31135.b3. PMID: 16940864

Clinical prediction guides

Burkholderia pseudomallei and melioidosis.
Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ
Nat Rev Microbiol 2024 Mar;22(3):155-169. Epub 2023 Oct 4 doi: 10.1038/s41579-023-00972-5. PMID: 37794173
Cutaneous melioidosis: An updated review and primer for the dermatologist.
Schwartzman G, Reddy SA, Berg SH, Currie BJ, Saavedra AP
J Am Acad Dermatol 2023 Dec;89(6):1201-1208. Epub 2023 Aug 13 doi: 10.1016/j.jaad.2023.07.1032. PMID: 37582471
Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections.
Medhasi S, Chantratita N
J Immunol Res 2022;2022:9710376. Epub 2022 May 26 doi: 10.1155/2022/9710376. PMID: 35664353Free PMC Article
The Burkholderia pseudomallei intracellular 'TRANSITome'.
Heacock-Kang Y, McMillan IA, Norris MH, Sun Z, Zarzycki-Siek J, Bluhm AP, Cabanas D, Norton RE, Ketheesan N, Miller JF, Schweizer HP, Hoang TT
Nat Commun 2021 Mar 26;12(1):1907. doi: 10.1038/s41467-021-22169-1. PMID: 33772012Free PMC Article
Melioidosis.
Peacock SJ
Curr Opin Infect Dis 2006 Oct;19(5):421-8. doi: 10.1097/01.qco.0000244046.31135.b3. PMID: 16940864

Recent systematic reviews

A systematic review of neglected tropical diseases (NTDs) in Myanmar.
Swe MMM, Phyo AP, Cooper BS, White NJ, Smithuis F, Ashley EA
PLoS Negl Trop Dis 2023 Nov;17(11):e0011706. Epub 2023 Nov 1 doi: 10.1371/journal.pntd.0011706. PMID: 37910592Free PMC Article
Efficacy and safety of co-trimoxazole in eradication phase of melioidosis; systematic review.
Keragala KARK, Gunathilaka MGRSS, Senevirathna RMISK, Jayaweera JAAS
Ann Clin Microbiol Antimicrob 2023 Aug 17;22(1):74. doi: 10.1186/s12941-023-00620-z. PMID: 37592339Free PMC Article
Burden and Risk Factors of Melioidosis in Southeast Asia: A Scoping Review.
Selvam K, Ganapathy T, Najib MA, Khalid MF, Abdullah NA, Harun A, Wan Mohammad WMZ, Aziah I
Int J Environ Res Public Health 2022 Nov 22;19(23) doi: 10.3390/ijerph192315475. PMID: 36497549Free PMC Article
Central nervous system melioidosis in the pediatric age group: review.
Prasad GL, Kini P, Divya S
Childs Nerv Syst 2017 Jun;33(6):1-6. Epub 2017 Apr 27 doi: 10.1007/s00381-017-3422-1. PMID: 28451778
Interventions for treating melioidosis.
Samuel M, Ti TY
Cochrane Database Syst Rev 2002;(4):CD001263. doi: 10.1002/14651858.CD001263. PMID: 12519552

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