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Melancholia

MedGen UID:
6288
Concept ID:
C0025193
Mental or Behavioral Dysfunction
Synonym: Melancholias
 
Monarch Initiative: MONDO:0002444

Definition

A subtype of depression characterized by the inability to find pleasure in positive things combined with physical agitation, insomnia, or decreased appetite. [from NCI]

Professional guidelines

PubMed

Kendler KS
Am J Psychiatry 2016 Aug 1;173(8):771-80. Epub 2016 May 3 doi: 10.1176/appi.ajp.2016.15121509. PMID: 27138588
Parker G, Paterson A
Curr Opin Psychiatry 2014 Jan;27(1):1-6. doi: 10.1097/YCO.0000000000000024. PMID: 24270479
Brown WA
Acta Psychiatr Scand Suppl 2007;(433):125-9. doi: 10.1111/j.1600-0447.2007.00970.x. PMID: 17280578

Recent clinical studies

Etiology

Parker G
Australas Psychiatry 2020 Jun;28(3):339-341. Epub 2020 Mar 11 doi: 10.1177/1039856220908167. PMID: 32157900
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Scott K, Lewis CC, Marti CN
J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):319-328. Epub 2019 Jan 8 doi: 10.1016/j.jaac.2018.07.908. PMID: 30768414Free PMC Article
Bergink V, Rasgon N, Wisner KL
Am J Psychiatry 2016 Dec 1;173(12):1179-1188. Epub 2016 Sep 9 doi: 10.1176/appi.ajp.2016.16040454. PMID: 27609245
Albrecht G, Sartore GM, Connor L, Higginbotham N, Freeman S, Kelly B, Stain H, Tonna A, Pollard G
Australas Psychiatry 2007;15 Suppl 1:S95-8. doi: 10.1080/10398560701701288. PMID: 18027145

Diagnosis

Parker G
Australas Psychiatry 2020 Jun;28(3):339-341. Epub 2020 Mar 11 doi: 10.1177/1039856220908167. PMID: 32157900
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Blashfield RK
J Nerv Ment Dis 2019 Sep;207(9):726-730. doi: 10.1097/NMD.0000000000000938. PMID: 30720602
Parker G, Paterson A
Curr Opin Psychiatry 2014 Jan;27(1):1-6. doi: 10.1097/YCO.0000000000000024. PMID: 24270479
Lancet 1991 Jun 29;337(8757):1573-4. PMID: 1675713

Therapy

Scott K, Lewis CC, Marti CN
J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):319-328. Epub 2019 Jan 8 doi: 10.1016/j.jaac.2018.07.908. PMID: 30768414Free PMC Article
Mulder R, Hamilton A, Irwin L, Boyce P, Morris G, Porter RJ, Malhi GS
Bipolar Disord 2018 Nov;20 Suppl 2:17-24. doi: 10.1111/bdi.12701. PMID: 30328223
Bergink V, Rasgon N, Wisner KL
Am J Psychiatry 2016 Dec 1;173(12):1179-1188. Epub 2016 Sep 9 doi: 10.1176/appi.ajp.2016.16040454. PMID: 27609245
Parker G, Paterson A
Curr Opin Psychiatry 2014 Jan;27(1):1-6. doi: 10.1097/YCO.0000000000000024. PMID: 24270479
Carroll BJ
Bipolar Disord 2012 Feb;14(1):1-5. doi: 10.1111/j.1399-5618.2011.00972.x. PMID: 22329467

Prognosis

Brydges CR, Bhattacharyya S, Dehkordi SM, Milaneschi Y, Penninx B, Jansen R, Kristal BS, Han X, Arnold M, Kastenmüller G, Bekhbat M, Mayberg HS, Craighead WE, Rush AJ, Fiehn O, Dunlop BW, Kaddurah-Daouk R; Mood Disorders Precision Medicine Consortium
Brain Behav Immun 2022 May;102:42-52. Epub 2022 Feb 4 doi: 10.1016/j.bbi.2022.02.003. PMID: 35131442Free PMC Article
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Scott K, Lewis CC, Marti CN
J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):319-328. Epub 2019 Jan 8 doi: 10.1016/j.jaac.2018.07.908. PMID: 30768414Free PMC Article
Rybakowski JK
J Affect Disord 2011 Feb;128(3):319-20. Epub 2010 Aug 7 doi: 10.1016/j.jad.2010.07.019. PMID: 20692707
Fink M, Taylor MA
Acta Psychiatr Scand Suppl 2007;(433):14-20. doi: 10.1111/j.1600-0447.2007.00958.x. PMID: 17280566

Clinical prediction guides

Brydges CR, Bhattacharyya S, Dehkordi SM, Milaneschi Y, Penninx B, Jansen R, Kristal BS, Han X, Arnold M, Kastenmüller G, Bekhbat M, Mayberg HS, Craighead WE, Rush AJ, Fiehn O, Dunlop BW, Kaddurah-Daouk R; Mood Disorders Precision Medicine Consortium
Brain Behav Immun 2022 May;102:42-52. Epub 2022 Feb 4 doi: 10.1016/j.bbi.2022.02.003. PMID: 35131442Free PMC Article
Kendler KS
JAMA Psychiatry 2020 Aug 1;77(8):863-868. doi: 10.1001/jamapsychiatry.2019.4709. PMID: 31995137
Scott K, Lewis CC, Marti CN
J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):319-328. Epub 2019 Jan 8 doi: 10.1016/j.jaac.2018.07.908. PMID: 30768414Free PMC Article
Parker G, McCraw S
J Affect Disord 2017 Jan 1;207:128-135. Epub 2016 Sep 25 doi: 10.1016/j.jad.2016.09.029. PMID: 27721186
Østergaard SD, Meyers BS, Flint AJ, Mulsant BH, Whyte EM, Ulbricht CM, Bech P, Rothschild AJ; STOP-PD Study Group
Acta Psychiatr Scand 2014 Mar;129(3):211-20. Epub 2013 Jun 25 doi: 10.1111/acps.12165. PMID: 23799875Free PMC Article

Recent systematic reviews

Almulla AF, Thipakorn Y, Vasupanrajit A, Tunvirachaisakul C, Oxenkrug G, Al-Hakeim HK, Maes M
Cells 2022 Oct 2;11(19) doi: 10.3390/cells11193112. PMID: 36231075Free PMC Article
Sani G, Tondo L, Undurraga J, Vázquez GH, Salvatore P, Baldessarini RJ
Int Rev Psychiatry 2020 Aug-Sep;32(5-6):466-470. Epub 2020 Mar 16 doi: 10.1080/09540261.2019.1708708. PMID: 32172612
Martino DJ, Szmulewicz AG, Valerio MP, Parker G
J Nerv Ment Dis 2019 Sep;207(9):792-798. doi: 10.1097/NMD.0000000000001090. PMID: 31464990
Juruena MF, Bocharova M, Agustini B, Young AH
J Affect Disord 2018 Jun;233:45-67. Epub 2017 Oct 6 doi: 10.1016/j.jad.2017.09.052. PMID: 29150144
Mosley PE, Marsh R, Carter A
Aust N Z J Psychiatry 2015 Nov;49(11):967-78. Epub 2015 Aug 14 doi: 10.1177/0004867415599845. PMID: 26276049

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