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Marburg virus disease

MedGen UID:
9888
•Concept ID:
C0024788
•
Disease or Syndrome
Synonyms: Marburg disease; Marburg hemorrhagic fever
SNOMED CT: Green monkey disease (77503002); Marburg virus disease (77503002); Vervet monkey disease (77503002); Marburg hemorrhagic fever (77503002); Viral hemorrhagic fever, Marburg (77503002)
 
Monarch Initiative: MONDO:0020500
Orphanet: ORPHA99826

Definition

Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMarburg virus disease

Professional guidelines

PubMed

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing.
Zumbrun EE, Garvey CB, Wells JB, Lynn GC, Van Tongeren S, Steffens JT, Wetzel KS, Gomba LM, O'Brien KA, Rossi FD, Zeng X, Lee ED, Raymond JLW, Hoffman DA, Jay AN, Brown ES, Kallgren PA, Norris SL, Cantey-Kiser J, Kudiya H, Arthur C, Blair C, Babusis D, Chu VC, Singh B, Bannister R, Porter DP, Cihlar T, Dye JM
Viruses 2023 Nov 28;15(12) doi: 10.3390/v15122335. PMID: 38140576Free PMC Article
Remote-Controlled and Pulse Pressure-Guided Fluid Treatment for Adult Patients with Viral Hemorrhagic Fevers.
Schultz MJ, Deen J, von Seidlein L, Sivakorn C, Kumar A, Adhikari NKJ, Wills B, Kekulé AS, Day NPJ, Cooper B, White NJ, Salam AP, Horby P, Olliaro P, Dondorp AM
Am J Trop Med Hyg 2021 Feb 16;104(4):1172-1175. doi: 10.4269/ajtmh.20-1515. PMID: 33591934Free PMC Article
BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Taylor R, Kotian P, Warren T, Panchal R, Bavari S, Julander J, Dobo S, Rose A, El-Kattan Y, Taubenheim B, Babu Y, Sheridan WP
J Infect Public Health 2016 May-Jun;9(3):220-6. Epub 2016 Apr 16 doi: 10.1016/j.jiph.2016.04.002. PMID: 27095300Free PMC Article

Recent clinical studies

Etiology

Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review.
Cuomo-Dannenburg G, McCain K, McCabe R, Unwin HJT, Doohan P, Nash RK, Hicks JT, Charniga K, Geismar C, Lambert B, Nikitin D, Skarp J, Wardle J, Kont M, Bhatia S, Imai N, van Elsland S, Cori A, Morgenstern C; Pathogen Epidemiology Review Group
Lancet Infect Dis 2024 May;24(5):e307-e317. Epub 2023 Nov 28 doi: 10.1016/S1473-3099(23)00515-7. PMID: 38040006Free PMC Article
Past and current advances in Marburg virus disease: a review.
Asad A, Aamir A, Qureshi NE, Bhimani S, Jatoi NN, Batra S, Ochani RK, Abbasi MK, Tariq MA, Diwan MN
Infez Med 2020 Sep 1;28(3):332-345. PMID: 32920568
Marburg virus disease: A summary for clinicians.
Kortepeter MG, Dierberg K, Shenoy ES, Cieslak TJ; Medical Countermeasures Working Group of the National Ebola Training and Education Center's (NETEC) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2020 Oct;99:233-242. Epub 2020 Aug 3 doi: 10.1016/j.ijid.2020.07.042. PMID: 32758690Free PMC Article
Viral genomics in Ebola virus research.
Di Paola N, Sanchez-Lockhart M, Zeng X, Kuhn JH, Palacios G
Nat Rev Microbiol 2020 Jul;18(7):365-378. Epub 2020 May 4 doi: 10.1038/s41579-020-0354-7. PMID: 32367066Free PMC Article
Ebola and Marburg haemorrhagic fever.
Rougeron V, Feldmann H, Grard G, Becker S, Leroy EM
J Clin Virol 2015 Mar;64:111-9. Epub 2015 Jan 23 doi: 10.1016/j.jcv.2015.01.014. PMID: 25660265Free PMC Article

Diagnosis

Past and current advances in Marburg virus disease: a review.
Asad A, Aamir A, Qureshi NE, Bhimani S, Jatoi NN, Batra S, Ochani RK, Abbasi MK, Tariq MA, Diwan MN
Infez Med 2020 Sep 1;28(3):332-345. PMID: 32920568
Ebola virus disease and Marburg disease in pregnancy: a review and management considerations for filovirus infection.
Bebell LM, Riley LE
Obstet Gynecol 2015 Jun;125(6):1293-1298. doi: 10.1097/AOG.0000000000000853. PMID: 26000499Free PMC Article
Mapping the zoonotic niche of Marburg virus disease in Africa.
Pigott DM, Golding N, Mylne A, Huang Z, Weiss DJ, Brady OJ, Kraemer MU, Hay SI
Trans R Soc Trop Med Hyg 2015 Jun;109(6):366-78. Epub 2015 Mar 27 doi: 10.1093/trstmh/trv024. PMID: 25820266Free PMC Article
Ebola and Marburg haemorrhagic fever.
Rougeron V, Feldmann H, Grard G, Becker S, Leroy EM
J Clin Virol 2015 Mar;64:111-9. Epub 2015 Jan 23 doi: 10.1016/j.jcv.2015.01.014. PMID: 25660265Free PMC Article
Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.
Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR
J Pathol 2015 Jan;235(2):153-74. doi: 10.1002/path.4456. PMID: 25297522

Therapy

Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review.
Cuomo-Dannenburg G, McCain K, McCabe R, Unwin HJT, Doohan P, Nash RK, Hicks JT, Charniga K, Geismar C, Lambert B, Nikitin D, Skarp J, Wardle J, Kont M, Bhatia S, Imai N, van Elsland S, Cori A, Morgenstern C; Pathogen Epidemiology Review Group
Lancet Infect Dis 2024 May;24(5):e307-e317. Epub 2023 Nov 28 doi: 10.1016/S1473-3099(23)00515-7. PMID: 38040006Free PMC Article
Marburg virus disease: A summary for clinicians.
Kortepeter MG, Dierberg K, Shenoy ES, Cieslak TJ; Medical Countermeasures Working Group of the National Ebola Training and Education Center's (NETEC) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2020 Oct;99:233-242. Epub 2020 Aug 3 doi: 10.1016/j.ijid.2020.07.042. PMID: 32758690Free PMC Article
Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates.
Suschak JJ, Schmaljohn CS
Hum Vaccin Immunother 2019;15(10):2359-2377. Epub 2019 Oct 7 doi: 10.1080/21645515.2019.1651140. PMID: 31589088Free PMC Article
Ebola and Marburg virus vaccines.
Reynolds P, Marzi A
Virus Genes 2017 Aug;53(4):501-515. Epub 2017 Apr 26 doi: 10.1007/s11262-017-1455-x. PMID: 28447193Free PMC Article
DNA vaccines for biodefense.
Dupuy LC, Schmaljohn CS
Expert Rev Vaccines 2009 Dec;8(12):1739-54. doi: 10.1586/erv.09.132. PMID: 19943766

Prognosis

Natural History of Marburg Virus Infection to Support Medical Countermeasure Development.
Comer JE, Brasel T, Massey S, Beasley DW, Cirimotich CM, Sanford DC, Chou YL, Niemuth NA, Novak J, Sabourin CL, Merchlinsky M, Long JP, Stavale EJ, Wolfe DN
Viruses 2022 Oct 18;14(10) doi: 10.3390/v14102291. PMID: 36298846Free PMC Article
A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'.
Glaze ER, Roy MJ, Dalrymple LW, Lanning LL
Comp Med 2015 Jun;65(3):241-59. PMID: 26141449Free PMC Article
Mapping the zoonotic niche of Marburg virus disease in Africa.
Pigott DM, Golding N, Mylne A, Huang Z, Weiss DJ, Brady OJ, Kraemer MU, Hay SI
Trans R Soc Trop Med Hyg 2015 Jun;109(6):366-78. Epub 2015 Mar 27 doi: 10.1093/trstmh/trv024. PMID: 25820266Free PMC Article
Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.
Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR
J Pathol 2015 Jan;235(2):153-74. doi: 10.1002/path.4456. PMID: 25297522
Marburg and Ebola virus infections in laboratory non-human primates: a literature review.
Schou S, Hansen AK
Comp Med 2000 Apr;50(2):108-23. PMID: 10857001

Clinical prediction guides

Drivers of African Filovirus (Ebola and Marburg) Outbreaks.
Stephens PR, Sundaram M, Ferreira S, Gottdenker N, Nipa KF, Schatz AM, Schmidt JP, Drake JM
Vector Borne Zoonotic Dis 2022 Sep;22(9):478-490. doi: 10.1089/vbz.2022.0020. PMID: 36084314Free PMC Article
Filovirus Research: How it Began.
Slenczka W
Curr Top Microbiol Immunol 2017;411:3-21. doi: 10.1007/82_2017_8. PMID: 28766193
Ebola and Marburg virus vaccines.
Reynolds P, Marzi A
Virus Genes 2017 Aug;53(4):501-515. Epub 2017 Apr 26 doi: 10.1007/s11262-017-1455-x. PMID: 28447193Free PMC Article
Mapping the zoonotic niche of Marburg virus disease in Africa.
Pigott DM, Golding N, Mylne A, Huang Z, Weiss DJ, Brady OJ, Kraemer MU, Hay SI
Trans R Soc Trop Med Hyg 2015 Jun;109(6):366-78. Epub 2015 Mar 27 doi: 10.1093/trstmh/trv024. PMID: 25820266Free PMC Article
Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.
Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR
J Pathol 2015 Jan;235(2):153-74. doi: 10.1002/path.4456. PMID: 25297522

Recent systematic reviews

Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review.
Cuomo-Dannenburg G, McCain K, McCabe R, Unwin HJT, Doohan P, Nash RK, Hicks JT, Charniga K, Geismar C, Lambert B, Nikitin D, Skarp J, Wardle J, Kont M, Bhatia S, Imai N, van Elsland S, Cori A, Morgenstern C; Pathogen Epidemiology Review Group
Lancet Infect Dis 2024 May;24(5):e307-e317. Epub 2023 Nov 28 doi: 10.1016/S1473-3099(23)00515-7. PMID: 38040006Free PMC Article
Infection Rates and Risk Factors for Infection Among Health Workers During Ebola and Marburg Virus Outbreaks: A Systematic Review.
Selvaraj SA, Lee KE, Harrell M, Ivanov I, Allegranzi B
J Infect Dis 2018 Nov 22;218(suppl_5):S679-S689. doi: 10.1093/infdis/jiy435. PMID: 30202878Free PMC Article
How severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence.
Nyakarahuka L, Kankya C, Krontveit R, Mayer B, Mwiine FN, Lutwama J, Skjerve E
BMC Infect Dis 2016 Nov 25;16(1):708. doi: 10.1186/s12879-016-2045-6. PMID: 27887599Free PMC Article
Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review.
Brainard J, Pond K, Hooper L, Edmunds K, Hunter P
PLoS Negl Trop Dis 2016 Feb;10(2):e0004475. Epub 2016 Feb 29 doi: 10.1371/journal.pntd.0004475. PMID: 26927697Free PMC Article
Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis.
Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR
Int J Epidemiol 2016 Feb;45(1):102-16. Epub 2015 Nov 20 doi: 10.1093/ije/dyv307. PMID: 26589246Free PMC Article

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