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Alcoholic liver diseases

MedGen UID:
9793
•Concept ID:
C0023896
•
Disease or Syndrome
Synonyms: Alcoholic Liver Disease; Alcoholic Liver Diseases; Liver Disease, Alcoholic; Liver Diseases, Alcoholic
SNOMED CT: ALD - Alcoholic liver disease (41309000); Alcoholic liver disease (41309000)
 
Monarch Initiative: MONDO:0043693

Definition

A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis. [from NCI]

Professional guidelines

PubMed

Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?
Bakasis AD, Androutsakos T
Cells 2021 May 15;10(5) doi: 10.3390/cells10051212. PMID: 34063534Free PMC Article
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
Kim MS, Ong M, Qu X
World J Gastroenterol 2016 Jan 7;22(1):8-23. doi: 10.3748/wjg.v22.i1.8. PMID: 26755857Free PMC Article
Alcoholic liver disease: treatment.
Suk KT, Kim MY, Baik SK
World J Gastroenterol 2014 Sep 28;20(36):12934-44. doi: 10.3748/wjg.v20.i36.12934. PMID: 25278689Free PMC Article

Recent clinical studies

Etiology

Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcohol, liver disease and the gut microbiota.
Bajaj JS
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):235-246. doi: 10.1038/s41575-018-0099-1. PMID: 30643227
ACG Clinical Guideline: Alcoholic Liver Disease.
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Pathogenesis of Alcoholic Liver Disease.
Dunn W, Shah VH
Clin Liver Dis 2016 Aug;20(3):445-56. Epub 2016 Mar 28 doi: 10.1016/j.cld.2016.02.004. PMID: 27373608Free PMC Article
Alcoholic disease: liver and beyond.
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Diagnosis

Pathophysiological Aspects of Alcohol Metabolism in the Liver.
Hyun J, Han J, Lee C, Yoon M, Jung Y
Int J Mol Sci 2021 May 27;22(11) doi: 10.3390/ijms22115717. PMID: 34071962Free PMC Article
Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
ACG Clinical Guideline: Alcoholic Liver Disease.
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Alcoholic disease: liver and beyond.
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Therapy

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease.
Yan C, Hu W, Tu J, Li J, Liang Q, Han S
J Transl Med 2023 May 4;21(1):300. doi: 10.1186/s12967-023-04166-8. PMID: 37143126Free PMC Article
Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease.
Wu X, Fan X, Miyata T, Kim A, Cajigas-Du Ross CK, Ray S, Huang E, Taiwo M, Arya R, Wu J, Nagy LE
Annu Rev Pathol 2023 Jan 24;18:411-438. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-030435. PMID: 36270295Free PMC Article
Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Alcoholic liver disease: pathogenesis and new therapeutic targets.
Gao B, Bataller R
Gastroenterology 2011 Nov;141(5):1572-85. Epub 2011 Sep 12 doi: 10.1053/j.gastro.2011.09.002. PMID: 21920463Free PMC Article

Prognosis

Alcohol-associated liver disease: Epidemiology and management.
Hernández-Évole H, Jiménez-Esquivel N, Pose E, Bataller R
Ann Hepatol 2024 Jan-Feb;29(1):101162. Epub 2023 Oct 12 doi: 10.1016/j.aohep.2023.101162. PMID: 37832648
Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases.
Crabb DW, Im GY, Szabo G, Mellinger JL, Lucey MR
Hepatology 2020 Jan;71(1):306-333. doi: 10.1002/hep.30866. PMID: 31314133
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Gut-liver axis in alcoholic liver disease.
Szabo G
Gastroenterology 2015 Jan;148(1):30-6. Epub 2014 Nov 11 doi: 10.1053/j.gastro.2014.10.042. PMID: 25447847Free PMC Article

Clinical prediction guides

ACG Clinical Guideline: Alcohol-Associated Liver Disease.
Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, Shah VH
Am J Gastroenterol 2024 Jan 1;119(1):30-54. Epub 2023 Sep 1 doi: 10.14309/ajg.0000000000002572. PMID: 38174913Free PMC Article
Alcohol-related hepatitis: A review article.
Chaudhry H, Sohal A, Iqbal H, Roytman M
World J Gastroenterol 2023 May 7;29(17):2551-2570. doi: 10.3748/wjg.v29.i17.2551. PMID: 37213401Free PMC Article
Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Alcoholic liver disease: Utility of animal models.
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article

Recent systematic reviews

miRNAs in patients with alcoholic liver disease: a systematic review and meta-analysis.
Hu T, Liu CH, Zheng Y, Ji J, Zheng Y, He SK, Wu D, Jiang W, Zeng Q, Zhang N, Tang H
Expert Rev Gastroenterol Hepatol 2024 Jun;18(6):283-292. Epub 2024 Jul 8 doi: 10.1080/17474124.2024.2374470. PMID: 38937981
Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects.
Xue H, Wei M, Ji L
Phytomedicine 2023 Sep;118:154961. Epub 2023 Jul 9 doi: 10.1016/j.phymed.2023.154961. PMID: 37453191
Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis.
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD.
Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM
Hepatology 2020 Nov;72(5):1605-1616. Epub 2020 Oct 27 doi: 10.1002/hep.31173. PMID: 32043613

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