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Alcoholic liver cirrhosis

MedGen UID:
6125
Concept ID:
C0023891
Disease or Syndrome
Synonyms: Alcoholic Cirrhosis; Alcoholic Hepatic Cirrhosis; Alcoholic Liver Cirrhosis; Hepatic Cirrhosis, Alcoholic; Liver Cirrhosis, Alcoholic
SNOMED CT: Alcoholic cirrhosis (420054005); Alcoholic liver cirrhosis (420054005); Alcoholic cirrhosis of liver (420054005)
 
Monarch Initiative: MONDO:0006644

Definition

A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcoholic liver cirrhosis

Professional guidelines

PubMed

Abassa KK, Xiao XP, Zhou HX, Wu XY, Guo YW, Wu B
Drug Alcohol Depend 2022 Apr 1;233:109377. Epub 2022 Feb 24 doi: 10.1016/j.drugalcdep.2022.109377. PMID: 35245761
Godil J, Barrett MJ, Ensrud E, Chahin N, Karam C
J Neurol Sci 2020 Nov 15;418:117098. Epub 2020 Aug 15 doi: 10.1016/j.jns.2020.117098. PMID: 32841917
Tilg H, Day CP
Nat Clin Pract Gastroenterol Hepatol 2007 Jan;4(1):24-34. doi: 10.1038/ncpgasthep0683. PMID: 17203086

Recent clinical studies

Etiology

Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Milić S, Lulić D, Štimac D, Ružić A, Zaputović L
Postgrad Med J 2016 Apr;92(1086):235-9. Epub 2016 Feb 5 doi: 10.1136/postgradmedj-2015-133755. PMID: 26850503
Fujii H, Kawada N
World J Gastroenterol 2014 Jul 7;20(25):8048-54. doi: 10.3748/wjg.v20.i25.8048. PMID: 25009376Free PMC Article
Hall M
Home Healthc Nurse 2012 Oct;30(9):543-50; quiz 550-2. doi: 10.1097/NHH.0b013e31826a6719. PMID: 23026991
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Diagnosis

Maharaj S, Murray D, Chang S, Cisak K
Cleve Clin J Med 2020 Nov 2;87(11):649-650. doi: 10.3949/ccjm.87a.20044. PMID: 33139258
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Mueller S, Seitz HK, Rausch V
World J Gastroenterol 2014 Oct 28;20(40):14626-41. doi: 10.3748/wjg.v20.i40.14626. PMID: 25356026Free PMC Article
Burnett DA, Sorrell MF
Clin Gastroenterol 1981 May;10(2):443-55. PMID: 7018752

Therapy

China L, Freemantle N, Forrest E, Kallis Y, Ryder SD, Wright G, Portal AJ, Becares Salles N, Gilroy DW, O'Brien A; ATTIRE Trial Investigators
N Engl J Med 2021 Mar 4;384(9):808-817. doi: 10.1056/NEJMoa2022166. PMID: 33657293
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Kizilgul M, Ozcelik O, Delibasi T
Indian J Gastroenterol 2016 Jul;35(4):253-9. Epub 2016 Jun 1 doi: 10.1007/s12664-016-0652-1. PMID: 27246833
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Prognosis

Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Patel A, Tillman BF
N Engl J Med 2022 Jan 27;386(4):e6. doi: 10.1056/NEJMicm2101673. PMID: 35081282
Maharaj S, Murray D, Chang S, Cisak K
Cleve Clin J Med 2020 Nov 2;87(11):649-650. doi: 10.3949/ccjm.87a.20044. PMID: 33139258
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Gilbert JD, Byard RW
Med Sci Law 2018 Jul;58(3):186-188. Epub 2018 May 21 doi: 10.1177/0025802418778165. PMID: 29783922

Clinical prediction guides

Dong W, Gong Y, Zhao J, Wang Y, Li B, Yang Y
Front Endocrinol (Lausanne) 2023;14:1281839. Epub 2024 Jan 8 doi: 10.3389/fendo.2023.1281839. PMID: 38260163Free PMC Article
Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D; GenomALC Consortium
J Hepatol 2022 Feb;76(2):275-282. Epub 2021 Oct 14 doi: 10.1016/j.jhep.2021.10.005. PMID: 34656649Free PMC Article
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Alpert L, Hart J
Clin Liver Dis 2016 Aug;20(3):473-89. Epub 2016 Apr 9 doi: 10.1016/j.cld.2016.02.006. PMID: 27373610
Chrostek L, Panasiuk A
World J Gastroenterol 2014 Jul 7;20(25):8018-23. doi: 10.3748/wjg.v20.i25.8018. PMID: 25009372Free PMC Article

Recent systematic reviews

Gratacós-Ginès J, Bruguera P, Pérez-Guasch M, López-Lazcano A, Borràs R, Hernández-Évole H, Pons-Cabrera MT, Lligoña A, Bataller R, Ginès P, López-Pelayo H, Pose E
Hepatology 2024 Feb 1;79(2):368-379. Epub 2023 Aug 25 doi: 10.1097/HEP.0000000000000570. PMID: 37625154
Wang G, Huang Y, Yang H, Lin H, Zhou S, Qian J
Surg Obes Relat Dis 2023 Jul;19(7):717-726. Epub 2022 Dec 21 doi: 10.1016/j.soard.2022.12.025. PMID: 36890087
Huang DQ, Tan DJH, Ng CH, Amangurbanova M, Sutter N, Lin Tay PW, Lim WH, Yong JN, Tang A, Syn N, Muthiah MD, Tan EXX, Dave S, Tay B, Majzoub AM, Gerberi D, Kim BK, Loomba R
Clin Gastroenterol Hepatol 2023 May;21(5):1169-1177. Epub 2022 Aug 5 doi: 10.1016/j.cgh.2022.06.032. PMID: 35940513Free PMC Article
Pavlov CS, Casazza G, Semenistaia M, Nikolova D, Tsochatzis E, Liusina E, Ivashkin VT, Gluud C
Cochrane Database Syst Rev 2016 Mar 2;3(3):CD011602. doi: 10.1002/14651858.CD011602.pub2. PMID: 26934429Free PMC Article
Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J
Aliment Pharmacol Ther 2016 Mar;43(5):562-74. Epub 2016 Jan 25 doi: 10.1111/apt.13523. PMID: 26806124

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