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Indeterminate leprosy

MedGen UID:
507841
•Concept ID:
C0021192
•
Disease or Syndrome
Synonyms: Group I leprosy; indeterminate leprosy; indeterminate leprosy [group I]; Type I leprosy; uncharacteristic leprosy
SNOMED CT: Type I leprosy (14386001); Indeterminate leprosy (14386001); Group I leprosy (14386001)
 
Monarch Initiative: MONDO:0001391

Definition

A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules. [from MONDO]

Professional guidelines

PubMed

Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
Bhandarkar SS, Cohen C, Kuruvila M, Rea TH, Mackelfresh JB, Lee DJ, Modlin RL, Arbiser JL
Arch Dermatol 2007 Dec;143(12):1527-9. doi: 10.1001/archderm.143.12.1527. PMID: 18087002
Leprosy. Recognition and treatment.
Ramos-e-Silva M, Rebello PF
Am J Clin Dermatol 2001;2(4):203-11. doi: 10.2165/00128071-200102040-00001. PMID: 11705247

Recent clinical studies

Etiology

Nevus depigmentosus: review of a mark of distinction.
Ullah F, Schwartz RA
Int J Dermatol 2019 Dec;58(12):1366-1370. Epub 2019 Feb 22 doi: 10.1111/ijd.14393. PMID: 30801693
Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Dermal dendrocytes FXIIIa+ are essential antigen-presenting cells in indeterminate leprosy.
de Alvarenga Lira ML, Pagliari C, de Lima Silva AA, de Andrade HF Jr, Duarte MI
Am J Dermatopathol 2015 Apr;37(4):269-73. doi: 10.1097/DAD.0000000000000238. PMID: 25365500
Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort.
Lockwood DN, Suneetha L, Sagili KD, Chaduvula MV, Mohammed I, van Brakel W, Smith WC, Nicholls P, Suneetha S
PLoS Negl Trop Dis 2011 Dec;5(12):e1327. Epub 2011 Dec 13 doi: 10.1371/journal.pntd.0001327. PMID: 22180790Free PMC Article
Leprosy. Recognition and treatment.
Ramos-e-Silva M, Rebello PF
Am J Clin Dermatol 2001;2(4):203-11. doi: 10.2165/00128071-200102040-00001. PMID: 11705247

Diagnosis

Nevus depigmentosus: review of a mark of distinction.
Ullah F, Schwartz RA
Int J Dermatol 2019 Dec;58(12):1366-1370. Epub 2019 Feb 22 doi: 10.1111/ijd.14393. PMID: 30801693
Cojedes: a leprosy hyperendemic state.
Aranzazu N, Parra JJ, Cardenas M, Rada E, Zerpa O, Rivera T, Borges R, Gonzalez P, Morales J, Sosa R, Sanchez F, Convit J
Int J Dermatol 2012 Feb;51(2):186-94. doi: 10.1111/j.1365-4632.2011.05080.x. PMID: 22250629
Leprosy. Recognition and treatment.
Ramos-e-Silva M, Rebello PF
Am J Clin Dermatol 2001;2(4):203-11. doi: 10.2165/00128071-200102040-00001. PMID: 11705247
Indeterminate leprosy.
Browne SG
Int J Dermatol 1985 Nov;24(9):555-9. doi: 10.1111/j.1365-4362.1985.tb05848.x. PMID: 3905636
Tinea incognito.
Ive FA, Marks R
Br Med J 1968 Jul 20;3(5611):149-52. doi: 10.1136/bmj.3.5611.149. PMID: 5662546Free PMC Article

Therapy

Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Childhood leprosy through the post-leprosy-elimination era: a retrospective analysis of epidemiological and clinical characteristics of disease over eleven years from a tertiary care hospital in North India.
Dogra S, Narang T, Khullar G, Kumar R, Saikia UN
Lepr Rev 2014 Dec;85(4):296-310. PMID: 25675654
Childhood leprosy: a retrospective descriptive study from Government Medical College, Kozhikode, Kerala, India.
Sasidharanpillai S, Binitha MP, Riyaz N, Ambooken B, Mariyath OK, George B, Janardhanan AK, Sherjeena PV
Lepr Rev 2014 Jun;85(2):100-10. PMID: 25255613
Leprosy. Recognition and treatment.
Ramos-e-Silva M, Rebello PF
Am J Clin Dermatol 2001;2(4):203-11. doi: 10.2165/00128071-200102040-00001. PMID: 11705247
Tinea incognito.
Ive FA, Marks R
Br Med J 1968 Jul 20;3(5611):149-52. doi: 10.1136/bmj.3.5611.149. PMID: 5662546Free PMC Article

Prognosis

Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil.
Stefani MMA, Rosa PS, Costa MB, Schetinni APM, Manhães I, Pontes MAA, Costa P, Fachin LRV, Batista IMFD, Virmond M, Pereira E, Penna MLF, Penna GO
PLoS One 2019;14(1):e0209491. Epub 2019 Jan 10 doi: 10.1371/journal.pone.0209491. PMID: 30629624Free PMC Article
Analysis of a novel multiplex polymerase chain reaction assay as a sensitive tool for the diagnosis of indeterminate and tuberculoid forms of leprosy.
Chaitanya VS, Cuello L, Das M, Sudharsan A, Ganesan P, Kanmani K, Rajan L, Ebenezer M
Int J Mycobacteriol 2017 Jan-Mar;6(1):1-8. doi: 10.4103/2212-5531.201885. PMID: 28317797
Clinical aspects of leprosy.
Talhari C, Talhari S, Penna GO
Clin Dermatol 2015 Jan-Feb;33(1):26-37. doi: 10.1016/j.clindermatol.2014.07.002. PMID: 25432808
Indeterminate leprosy: a seroimmunological and histochemical evaluation.
Sekar B, Sharma RN, Anandan D, Vasanthi B, Jayasheela M
Lepr Rev 1994 Sep;65(3):167-74. doi: 10.5935/0305-7518.19940016. PMID: 8942147
Indeterminate leprosy: histopathologic and histochemical predictive parameters involved in its possible change to paucibacillary or multibacillary leprosy.
Takahashi MD, Andrade HF Jr, Wakamatsu A, Siqueira S, De Brito T
Int J Lepr Other Mycobact Dis 1991 Mar;59(1):12-9. PMID: 2030308

Clinical prediction guides

Analysis of a novel multiplex polymerase chain reaction assay as a sensitive tool for the diagnosis of indeterminate and tuberculoid forms of leprosy.
Chaitanya VS, Cuello L, Das M, Sudharsan A, Ganesan P, Kanmani K, Rajan L, Ebenezer M
Int J Mycobacteriol 2017 Jan-Mar;6(1):1-8. doi: 10.4103/2212-5531.201885. PMID: 28317797
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City.
Lobo AC, Pai RR, Gautam K, Kuruvila M
Indian J Lepr 2014 Oct-Dec;86(4):147-54. PMID: 26411247
Childhood leprosy through the post-leprosy-elimination era: a retrospective analysis of epidemiological and clinical characteristics of disease over eleven years from a tertiary care hospital in North India.
Dogra S, Narang T, Khullar G, Kumar R, Saikia UN
Lepr Rev 2014 Dec;85(4):296-310. PMID: 25675654
Indeterminate leprosy: histopathologic and histochemical predictive parameters involved in its possible change to paucibacillary or multibacillary leprosy.
Takahashi MD, Andrade HF Jr, Wakamatsu A, Siqueira S, De Brito T
Int J Lepr Other Mycobact Dis 1991 Mar;59(1):12-9. PMID: 2030308
Immunological changes observed in indeterminate and lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG.
Convit J, Aranzazu N, Pinardi M, Ulrich M
Clin Exp Immunol 1979 May;36(2):214-20. PMID: 383331Free PMC Article

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