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Type III hypersensitivity disease

MedGen UID:
7021
•Concept ID:
C0020951
•
Disease or Syndrome
Synonyms: Disease, Immune Complex; Diseases, Immune Complex; Hypersensitivities, Type III; Hypersensitivity, Type III; Immune Complex Disease; Immune Complex Diseases; Type III Hypersensitivities; Type III Hypersensitivity
 
Monarch Initiative: MONDO:0007004

Definition

Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType III hypersensitivity disease

Professional guidelines

PubMed

Autoimmune encephalitis: clinical spectrum and management.
Uy CE, Binks S, Irani SR
Pract Neurol 2021 Oct;21(5):412-423. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002567. PMID: 34108243Free PMC Article
Atopic Dermatitis: Diagnosis and Treatment.
Frazier W, Bhardwaj N
Am Fam Physician 2020 May 15;101(10):590-598. PMID: 32412211
European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.
Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Rheumatology (Oxford) 2019 Sep 1;58(9):1607-1616. doi: 10.1093/rheumatology/kez041. PMID: 30879080

Recent clinical studies

Etiology

Neutrophilic dermatoses.
Delaleu J, Lepelletier C, Calugareanu A, De Masson A, Charvet E, Petit A, Giurgea I, Amselem S, Karabina S, Jachiet M, Mahevas T, Ram-Wolff C, Vignon-Pennamen MD, Bagot M, Battistella M, Bouaziz JD
Rev Med Interne 2022 Dec;43(12):727-738. Epub 2022 Jul 20 doi: 10.1016/j.revmed.2022.06.007. PMID: 35870984
European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.
Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Rheumatology (Oxford) 2019 Sep 1;58(9):1607-1616. doi: 10.1093/rheumatology/kez041. PMID: 30879080
Henoch-Schönlein Purpura: A Literature Review.
Hetland LE, Susrud KS, Lindahl KH, Bygum A
Acta Derm Venereol 2017 Nov 15;97(10):1160-1166. doi: 10.2340/00015555-2733. PMID: 28654132
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
HMGB1 in health and disease.
Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, Huang J, Yu Y, Fan XG, Yan Z, Sun X, Wang H, Wang Q, Tsung A, Billiar TR, Zeh HJ 3rd, Lotze MT, Tang D
Mol Aspects Med 2014 Dec;40:1-116. Epub 2014 Jul 8 doi: 10.1016/j.mam.2014.05.001. PMID: 25010388Free PMC Article

Diagnosis

Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.
Marzano AV, Maronese CA, Genovese G, Ferrucci S, Moltrasio C, Asero R, Cugno M
J Allergy Clin Immunol 2022 Apr;149(4):1137-1149. doi: 10.1016/j.jaci.2022.02.007. PMID: 35396080
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations.
Frumholtz L, Laurent-Roussel S, Lipsker D, Terrier B
Clin Rev Allergy Immunol 2021 Oct;61(2):181-193. doi: 10.1007/s12016-020-08788-4. PMID: 32378145
Henoch-Schönlein Purpura in Children: An Updated Review.
Leung AKC, Barankin B, Leong KF
Curr Pediatr Rev 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708. PMID: 32384035
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001

Therapy

Henoch-Schönlein Purpura in Children: An Updated Review.
Leung AKC, Barankin B, Leong KF
Curr Pediatr Rev 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708. PMID: 32384035
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Henoch-Schönlein purpura in children.
Trnka P
J Paediatr Child Health 2013 Dec;49(12):995-1003. Epub 2013 Oct 18 doi: 10.1111/jpc.12403. PMID: 24134307
Small vessel vasculitis.
Brogan P, Eleftheriou D, Dillon M
Pediatr Nephrol 2010 Jun;25(6):1025-35. Epub 2009 Nov 3 doi: 10.1007/s00467-009-1317-4. PMID: 19885685Free PMC Article
Henoch-Schönlein purpura.
Szer IS
Curr Opin Rheumatol 1994 Jan;6(1):25-31. doi: 10.1097/00002281-199401000-00005. PMID: 8031676

Prognosis

Management of IgA Vasculitis with Nephritis.
Delbet JD, Parmentier C, Herbez Rea C, Mouche A, Ulinski T
Paediatr Drugs 2021 Sep;23(5):425-435. Epub 2021 Aug 16 doi: 10.1007/s40272-021-00464-0. PMID: 34396492
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Henoch-Schönlein Purpura in Children: An Updated Review.
Leung AKC, Barankin B, Leong KF
Curr Pediatr Rev 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708. PMID: 32384035
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Henoch-Schönlein purpura in children.
Trnka P
J Paediatr Child Health 2013 Dec;49(12):995-1003. Epub 2013 Oct 18 doi: 10.1111/jpc.12403. PMID: 24134307

Clinical prediction guides

Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis.
Barbour SJ, Coppo R, Er L, Pillebout E, Russo ML, Alpers CE, Fogo AB, Ferrario F, Jennette JC, Roberts ISD, Cook HT, Ding J, Su B, Zhong X, Fervenza FC, Zand L, Peruzzi L, Lucchetti L, Katafuchi R, Shima Y, Yoshikawa N, Ichikawa D, Suzuki Y, Murer L, Wyatt RJ, Park C, Nelson RD, Narus JH, Wenderfer S, Geetha D, Daugas E, Monteiro RC, Nakatani S, Mastrangelo A, Nuutinen M, Koskela M, Weber LT, Hackl A, Pohl M, Pecoraro C, Tsuboi N, Yokoo T, Takafumi I, Fujimoto S, Conti G, Santoro D, Materassi M, Zhang H, Shi S, Liu ZH, Tesar V, Maixnerova D, Avila-Casado C, Bajema I, Barreca A, Becker JU, Comstock JM, Cornea V, Eldin K, Hernandez LH, Hou J, Joh K, Lin M, Messias N, Muda AO, Pagni F, Diomedi-Camassei F, Tokola H, D'Armiento M, Seidl M, Rosenberg A, Sannier A, Soares MF, Wang S, Zeng C, Haas M
Clin J Am Soc Nephrol 2024 Apr 1;19(4):438-451. Epub 2024 Jan 23 doi: 10.2215/CJN.0000000000000398. PMID: 38261310Free PMC Article
The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease.
Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, Fuller A, Rosenthal A, Becce F, Bardin T, Ea HK, Filippou G, Fitzgerald J, Iagnocco A, Lioté F, McCarthy GM, Ramonda R, Richette P, Sivera F, Andrés M, Cipolletta E, Doherty M, Pascual E, Perez-Ruiz F, So A, Jansen TL, Kohler MJ, Stamp LK, Yinh J, Adinolfi A, Arad U, Aung T, Benillouche E, Bortoluzzi A, Dau J, Maningding E, Fang MA, Figus FA, Filippucci E, Haslett J, Janssen M, Kaldas M, Kimoto M, Leamy K, Navarro GM, Sarzi-Puttini P, Scirè C, Silvagni E, Sirotti S, Stack JR, Truong L, Xie C, Yokose C, Hendry AM, Terkeltaub R, Taylor WJ, Choi HK
Ann Rheum Dis 2023 Oct;82(10):1248-1257. Epub 2023 Jul 26 doi: 10.1136/ard-2023-224575. PMID: 37495237Free PMC Article
Calprotectin: from biomarker to biological function.
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE
Gut 2021 Oct;70(10):1978-1988. Epub 2021 Jun 18 doi: 10.1136/gutjnl-2021-324855. PMID: 34145045Free PMC Article
Henoch-Schönlein Purpura in Children: An Updated Review.
Leung AKC, Barankin B, Leong KF
Curr Pediatr Rev 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708. PMID: 32384035
IL-6/IL-6 receptor system and its role in physiological and pathological conditions.
Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M
Clin Sci (Lond) 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340. PMID: 22029668

Recent systematic reviews

Infections following bispecific antibodies in myeloma: a systematic review and meta-analysis.
Reynolds G, Cliff ERS, Mohyuddin GR, Popat R, Midha S, Liet Hing MN, Harrison SJ, Kesselheim AS, Teh BW
Blood Adv 2023 Oct 10;7(19):5898-5903. doi: 10.1182/bloodadvances.2023010539. PMID: 37467036Free PMC Article
Role of NLRP3 in the pathogenesis and treatment of gout arthritis.
Liu YR, Wang JQ, Li J
Front Immunol 2023;14:1137822. Epub 2023 Mar 27 doi: 10.3389/fimmu.2023.1137822. PMID: 37051231Free PMC Article
The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.
Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Ann Rheum Dis 2022 May;81(5):601-613. Epub 2022 Jan 27 doi: 10.1136/annrheumdis-2021-221814. PMID: 35086813Free PMC Article
The Gut Microbiome, Aging, and Longevity: A Systematic Review.
Badal VD, Vaccariello ED, Murray ER, Yu KE, Knight R, Jeste DV, Nguyen TT
Nutrients 2020 Dec 7;12(12) doi: 10.3390/nu12123759. PMID: 33297486Free PMC Article
Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases.
Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstrom P, Manton DJ, Montero E, Pitts N, Rangé H, Schlueter N, Teughels W, Twetman S, Van Loveren C, Van der Weijden F, Vieira AR, Schulte AG
J Clin Periodontol 2017 Mar;44 Suppl 18:S39-S51. doi: 10.1111/jcpe.12685. PMID: 28266114

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