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Immunoglobulin hypercatabolism

MedGen UID:
43817
•Concept ID:
C0020800
•
Disease or Syndrome
Synonyms: Hypercatabolic Hypoproteinemia, Idiopathic; Hypercatabolic Hypoproteinemias, Idiopathic; Hypoproteinemia, Idiopathic Hypercatabolic; Hypoproteinemias, Idiopathic Hypercatabolic; Idiopathic Hypercatabolic Hypoproteinemia; Idiopathic Hypercatabolic Hypoproteinemias
SNOMED CT: Immunoglobulin hypercatabolism (234565009); Idiopathic hypercatabolic hypoproteinemia (234565009)

Professional guidelines

PubMed

Use of octreotide for the treatment of protein-losing enteropathy in dogs: Retrospective study of 18 cases.
Jablonski SA, Mazepa ASW, Tolbert MK
J Vet Intern Med 2024 Jan-Feb;38(1):145-151. Epub 2023 Dec 1 doi: 10.1111/jvim.16966. PMID: 38038236Free PMC Article
Diagnosis and Management of Lymphatic Disorders in Congenital Heart Disease.
Kelly B, Mohanakumar S, Hjortdal VE
Curr Cardiol Rep 2020 Oct 10;22(12):164. doi: 10.1007/s11886-020-01405-y. PMID: 33037935Free PMC Article
Comparative pathophysiology and management of protein-losing enteropathy.
Craven MD, Washabau RJ
J Vet Intern Med 2019 Mar;33(2):383-402. Epub 2019 Feb 14 doi: 10.1111/jvim.15406. PMID: 30762910Free PMC Article

Recent clinical studies

Etiology

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ozen A, Chongsrisawat V, Sefer AP, Kolukisa B, Jalbert JJ, Meagher KA, Brackin T, Feldman HB, Baris S, Karakoc-Aydiner E, Ergelen R, Fuss IJ, Moorman H, Suratannon N, Suphapeetiporn K, Perlee L, Harari OA, Yancopoulos GD, Lenardo MJ; Pozelimab CHAPLE Working Group
Lancet 2024 Feb 17;403(10427):645-656. Epub 2024 Jan 23 doi: 10.1016/S0140-6736(23)02358-9. PMID: 38278170Free PMC Article
Use of octreotide for the treatment of protein-losing enteropathy in dogs: Retrospective study of 18 cases.
Jablonski SA, Mazepa ASW, Tolbert MK
J Vet Intern Med 2024 Jan-Feb;38(1):145-151. Epub 2023 Dec 1 doi: 10.1111/jvim.16966. PMID: 38038236Free PMC Article
Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study.
Goldberg CS, Trachtenberg F, William Gaynor J, Mahle WT, Ravishankar C, Schwartz SM, Cnota JF, Ohye RG, Gongwer R, Taylor M, Paridon S, Frommelt PC, Afton K, Atz AM, Burns KM, Detterich JA, Hill KD, Cabrera AG, Lewis AB, Pizarro C, Shah A, Sharma B, Newburger JW; Pediatric Heart Network Investigators
Circulation 2023 Oct 24;148(17):1330-1339. Epub 2023 Oct 5 doi: 10.1161/CIRCULATIONAHA.123.065192. PMID: 37795623Free PMC Article
Protein-Losing Enteropathy Following Fontan Palliation.
Al Balushi A, Mackie AS
Can J Cardiol 2019 Dec;35(12):1857-1860. Epub 2019 Jul 26 doi: 10.1016/j.cjca.2019.07.625. PMID: 31711823
Gastrointestinal system involvement in systemic lupus erythematosus.
Li Z, Xu D, Wang Z, Wang Y, Zhang S, Li M, Zeng X
Lupus 2017 Oct;26(11):1127-1138. Epub 2017 May 19 doi: 10.1177/0961203317707825. PMID: 28523968

Diagnosis

Protein-Losing Enteropathy.
Ozen A, Lenardo MJ
N Engl J Med 2023 Aug 24;389(8):733-748. doi: 10.1056/NEJMra2301594. PMID: 37611123
Protein-losing enteropathy.
Elli L, Topa M, Rimondi A
Curr Opin Gastroenterol 2020 May;36(3):238-244. doi: 10.1097/MOG.0000000000000629. PMID: 32073507
Protein-Losing Enteropathy Following Fontan Palliation.
Al Balushi A, Mackie AS
Can J Cardiol 2019 Dec;35(12):1857-1860. Epub 2019 Jul 26 doi: 10.1016/j.cjca.2019.07.625. PMID: 31711823
Assessment of intestinal malabsorption.
Nikaki K, Gupte GL
Best Pract Res Clin Gastroenterol 2016 Apr;30(2):225-35. Epub 2016 Mar 8 doi: 10.1016/j.bpg.2016.03.003. PMID: 27086887
Clinical practice. Protein-losing enteropathy in children.
Braamskamp MJ, Dolman KM, Tabbers MM
Eur J Pediatr 2010 Oct;169(10):1179-85. Epub 2010 Jun 23 doi: 10.1007/s00431-010-1235-2. PMID: 20571826Free PMC Article

Therapy

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ozen A, Chongsrisawat V, Sefer AP, Kolukisa B, Jalbert JJ, Meagher KA, Brackin T, Feldman HB, Baris S, Karakoc-Aydiner E, Ergelen R, Fuss IJ, Moorman H, Suratannon N, Suphapeetiporn K, Perlee L, Harari OA, Yancopoulos GD, Lenardo MJ; Pozelimab CHAPLE Working Group
Lancet 2024 Feb 17;403(10427):645-656. Epub 2024 Jan 23 doi: 10.1016/S0140-6736(23)02358-9. PMID: 38278170Free PMC Article
Use of octreotide for the treatment of protein-losing enteropathy in dogs: Retrospective study of 18 cases.
Jablonski SA, Mazepa ASW, Tolbert MK
J Vet Intern Med 2024 Jan-Feb;38(1):145-151. Epub 2023 Dec 1 doi: 10.1111/jvim.16966. PMID: 38038236Free PMC Article
Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study.
Goldberg CS, Trachtenberg F, William Gaynor J, Mahle WT, Ravishankar C, Schwartz SM, Cnota JF, Ohye RG, Gongwer R, Taylor M, Paridon S, Frommelt PC, Afton K, Atz AM, Burns KM, Detterich JA, Hill KD, Cabrera AG, Lewis AB, Pizarro C, Shah A, Sharma B, Newburger JW; Pediatric Heart Network Investigators
Circulation 2023 Oct 24;148(17):1330-1339. Epub 2023 Oct 5 doi: 10.1161/CIRCULATIONAHA.123.065192. PMID: 37795623Free PMC Article
Protein-Losing Enteropathy Following Fontan Palliation.
Al Balushi A, Mackie AS
Can J Cardiol 2019 Dec;35(12):1857-1860. Epub 2019 Jul 26 doi: 10.1016/j.cjca.2019.07.625. PMID: 31711823
Transcatheter Fontan takedown.
Hallbergson A, Mascio CE, Rome JJ
Catheter Cardiovasc Interv 2015 Nov;86(5):849-54. Epub 2015 May 6 doi: 10.1002/ccd.25963. PMID: 25945427

Prognosis

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study.
Goldberg CS, Trachtenberg F, William Gaynor J, Mahle WT, Ravishankar C, Schwartz SM, Cnota JF, Ohye RG, Gongwer R, Taylor M, Paridon S, Frommelt PC, Afton K, Atz AM, Burns KM, Detterich JA, Hill KD, Cabrera AG, Lewis AB, Pizarro C, Shah A, Sharma B, Newburger JW; Pediatric Heart Network Investigators
Circulation 2023 Oct 24;148(17):1330-1339. Epub 2023 Oct 5 doi: 10.1161/CIRCULATIONAHA.123.065192. PMID: 37795623Free PMC Article
Gastrointestinal and hepatic involvement in paediatric systemic lupus erythematosus.
Trapani S, Rubino C, Simonini G, Indolfi G
Clin Exp Rheumatol 2021 Jul-Aug;39(4):899-906. Epub 2021 Mar 2 doi: 10.55563/clinexprheumatol/oebrcq. PMID: 33666164
Protein-Losing Enteropathy Following Fontan Palliation.
Al Balushi A, Mackie AS
Can J Cardiol 2019 Dec;35(12):1857-1860. Epub 2019 Jul 26 doi: 10.1016/j.cjca.2019.07.625. PMID: 31711823
Protein-losing enteropathy in inflammatory bowel diseases.
Furfaro F, Bezzio C, Maconi G
Minerva Gastroenterol Dietol 2015 Dec;61(4):261-5. Epub 2015 Oct 7 PMID: 26446687
Clinical practice. Protein-losing enteropathy in children.
Braamskamp MJ, Dolman KM, Tabbers MM
Eur J Pediatr 2010 Oct;169(10):1179-85. Epub 2010 Jun 23 doi: 10.1007/s00431-010-1235-2. PMID: 20571826Free PMC Article

Clinical prediction guides

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study.
Goldberg CS, Trachtenberg F, William Gaynor J, Mahle WT, Ravishankar C, Schwartz SM, Cnota JF, Ohye RG, Gongwer R, Taylor M, Paridon S, Frommelt PC, Afton K, Atz AM, Burns KM, Detterich JA, Hill KD, Cabrera AG, Lewis AB, Pizarro C, Shah A, Sharma B, Newburger JW; Pediatric Heart Network Investigators
Circulation 2023 Oct 24;148(17):1330-1339. Epub 2023 Oct 5 doi: 10.1161/CIRCULATIONAHA.123.065192. PMID: 37795623Free PMC Article
Growth in Children with a Fontan Circulation.
Mancilla EE, Zielonka B, Roizen JD, Dodds KM, Rand EB, Heimall JR, Chen F, Wu C, Goldberg DJ, Rychik J
J Pediatr 2021 Aug;235:149-155.e2. Epub 2021 Apr 19 doi: 10.1016/j.jpeds.2021.04.019. PMID: 33887332
Sjögren syndrome associated with protein-losing enteropathy: case-based review.
de Carvalho JF, Lerner A, Gonçalves CM, Shoenfeld Y
Clin Rheumatol 2021 Jun;40(6):2491-2497. Epub 2020 Nov 3 doi: 10.1007/s10067-020-05487-5. PMID: 33145631
The Fontan operation: the long-term outlook.
Hsu DT
Curr Opin Pediatr 2015 Oct;27(5):569-75. doi: 10.1097/MOP.0000000000000271. PMID: 26281036
Eosinophilic gastroenteritis.
Lee M, Hodges WG, Huggins TL, Lee EL
South Med J 1996 Feb;89(2):189-94. doi: 10.1097/00007611-199602000-00006. PMID: 8578348

Recent systematic reviews

ANCA-associated vasculitis with protein-losing enteropathy is characterized by hypocomplementemia.
Goto M, Tsuchida Y, Terada K, Takahashi H, Sugimori Y, Komai T, Iwasaki Y, Shoda H, Fujio K
Rheumatol Int 2022 Oct;42(10):1863-1872. Epub 2021 Jun 22 doi: 10.1007/s00296-021-04923-2. PMID: 34156527
Gastrointestinal system involvement in systemic lupus erythematosus.
Li Z, Xu D, Wang Z, Wang Y, Zhang S, Li M, Zeng X
Lupus 2017 Oct;26(11):1127-1138. Epub 2017 May 19 doi: 10.1177/0961203317707825. PMID: 28523968
Towards a proposal for a universal diagnostic definition of protein-losing enteropathy in Fontan patients: a systematic review.
Udink Ten Cate FE, Hannes T, Germund I, Khalil M, Huntgeburth M, Apitz C, Brockmeier K, Sreeram N
Heart 2016 Jul 15;102(14):1115-9. Epub 2016 Mar 31 doi: 10.1136/heartjnl-2015-308823. PMID: 27033590
Diagnostic accuracy of nuclear medicine imaging in protein losing enteropathy : systematic review and meta-analysis of the literature.
Khalesi M, Nakhaei AA, Seyed AJ, Treglia G, Zakavi SR, Sadeghi R, Kianifar HR
Acta Gastroenterol Belg 2013 Dec;76(4):413-22. PMID: 24592545
Lupus protein-losing enteropathy (LUPLE): a systematic review.
Al-Mogairen SM
Rheumatol Int 2011 Aug;31(8):995-1001. Epub 2011 Feb 23 doi: 10.1007/s00296-011-1827-9. PMID: 21344315

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