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Hyperalgesia

MedGen UID:
6961
•Concept ID:
C0020429
•
Sign or Symptom
Synonyms: Hyperalgesias; Hyperalgesic Sensation; Hyperalgesic Sensations; Hyperalgia; Sensation, Hyperalgesic; Sensations, Hyperalgesic
SNOMED CT: Hyperalgia (55406008); Increased sensitivity to painful stimulus (55406008); Hyperalgesia (55406008); Hyperpathia (55406008)

Definition

Abnormally increased pain sense. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperalgesia

Professional guidelines

PubMed

Methadone for Pain Management: A Pharmacotherapeutic Review.
Kreutzwiser D, Tawfic QA
CNS Drugs 2020 Aug;34(8):827-839. doi: 10.1007/s40263-020-00743-3. PMID: 32564328
Fibromyalgia Pathogenesis and Treatment Options Update.
Chinn S, Caldwell W, Gritsenko K
Curr Pain Headache Rep 2016 Apr;20(4):25. doi: 10.1007/s11916-016-0556-x. PMID: 26922414
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article

Recent clinical studies

Etiology

Allodynia and Dysmenorrhea.
Jarrell J, Arendt-Nielsen L
J Obstet Gynaecol Can 2016 Mar;38(3):270-4. Epub 2016 Mar 15 doi: 10.1016/j.jogc.2016.02.001. PMID: 27106198
ThermoTRPs and Pain.
Laing RJ, Dhaka A
Neuroscientist 2016 Apr;22(2):171-87. Epub 2015 Jan 21 doi: 10.1177/1073858414567884. PMID: 25608689Free PMC Article
Fentanyl-induced hyperalgesia in acute pain management.
Lyons PJ, Rivosecchi RM, Nery JP, Kane-Gill SL
J Pain Palliat Care Pharmacother 2015 Jun;29(2):153-60. doi: 10.3109/15360288.2015.1035835. PMID: 26095487
Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.
Fletcher D, Martinez V
Br J Anaesth 2014 Jun;112(6):991-1004. doi: 10.1093/bja/aeu137. PMID: 24829420
Diagnosis and clinical presentation of osteoarthritis.
Abhishek A, Doherty M
Rheum Dis Clin North Am 2013 Feb;39(1):45-66. doi: 10.1016/j.rdc.2012.10.007. PMID: 23312410

Diagnosis

Complex regional pain syndrome: An updated comprehensive review.
Kessler A, Yoo M, Calisoff R
NeuroRehabilitation 2020;47(3):253-264. doi: 10.3233/NRE-208001. PMID: 32986618
Mechanical allodynia.
Lolignier S, Eijkelkamp N, Wood JN
Pflugers Arch 2015 Jan;467(1):133-9. Epub 2014 May 22 doi: 10.1007/s00424-014-1532-0. PMID: 24846747Free PMC Article
Diagnosis and clinical presentation of osteoarthritis.
Abhishek A, Doherty M
Rheum Dis Clin North Am 2013 Feb;39(1):45-66. doi: 10.1016/j.rdc.2012.10.007. PMID: 23312410
A comprehensive review of opioid-induced hyperalgesia.
Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L
Pain Physician 2011 Mar-Apr;14(2):145-61. PMID: 21412369
Quantitative sensory testing: a comprehensive protocol for clinical trials.
Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD
Eur J Pain 2006 Jan;10(1):77-88. doi: 10.1016/j.ejpain.2005.02.003. PMID: 16291301

Therapy

Interventional Treatments for Postherpetic Neuralgia: A Systematic Review.
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
The neuropathic pain: An overview of the current treatment and future therapeutic approaches.
Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E
Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419838383. doi: 10.1177/2058738419838383. PMID: 30900486Free PMC Article
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W
Anesthesiology 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. PMID: 29462012Free PMC Article
Opioids for low back pain.
Deyo RA, Von Korff M, Duhrkoop D
BMJ 2015 Jan 5;350:g6380. doi: 10.1136/bmj.g6380. PMID: 25561513Free PMC Article
Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.
Fletcher D, Martinez V
Br J Anaesth 2014 Jun;112(6):991-1004. doi: 10.1093/bja/aeu137. PMID: 24829420

Prognosis

Complex Regional Pain Syndrome, Current Concepts and Treatment Options.
Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD
Curr Pain Headache Rep 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7. PMID: 29404787
Opioid Analgesics.
Jamison RN, Mao J
Mayo Clin Proc 2015 Jul;90(7):957-68. doi: 10.1016/j.mayocp.2015.04.010. PMID: 26141334
Sensitization and pain.
Aguggia M, Saracco MG, Cavallini M, Bussone G, Cortelli P
Neurol Sci 2013 May;34 Suppl 1:S37-40. doi: 10.1007/s10072-013-1382-0. PMID: 23695043
Diagnosis and clinical presentation of osteoarthritis.
Abhishek A, Doherty M
Rheum Dis Clin North Am 2013 Feb;39(1):45-66. doi: 10.1016/j.rdc.2012.10.007. PMID: 23312410
Validity of four pain intensity rating scales.
Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP
Pain 2011 Oct;152(10):2399-2404. doi: 10.1016/j.pain.2011.07.005. PMID: 21856077

Clinical prediction guides

Efficacy of galcanezumab in migraine central sensitization.
Danno D, Imai N, Kitamura S, Ishizaki K, Kikui S, Takeshima T
Sci Rep 2024 Sep 18;14(1):21824. doi: 10.1038/s41598-024-72282-6. PMID: 39294310Free PMC Article
Gold Standard for Diagnosis of DPN.
Yu Y
Front Endocrinol (Lausanne) 2021;12:719356. Epub 2021 Oct 26 doi: 10.3389/fendo.2021.719356. PMID: 34764937Free PMC Article
Quantitative sensory testing (QST). English version.
Mücke M, Cuhls H, Radbruch L, Baron R, Maier C, Tölle T, Treede RD, Rolke R
Schmerz 2021 Nov;35(Suppl 3):153-160. doi: 10.1007/s00482-015-0093-2. PMID: 26826097
Validity of four pain intensity rating scales.
Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP
Pain 2011 Oct;152(10):2399-2404. doi: 10.1016/j.pain.2011.07.005. PMID: 21856077
The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs.
Bennett M
Pain 2001 May;92(1-2):147-57. doi: 10.1016/s0304-3959(00)00482-6. PMID: 11323136

Recent systematic reviews

Pain sensitivity is reduced by exercise training: Evidence from a systematic review and meta-analysis.
Belavy DL, Van Oosterwijck J, Clarkson M, Dhondt E, Mundell NL, Miller CT, Owen PJ
Neurosci Biobehav Rev 2021 Jan;120:100-108. Epub 2020 Nov 27 doi: 10.1016/j.neubiorev.2020.11.012. PMID: 33253748
Interventional Treatments for Postherpetic Neuralgia: A Systematic Review.
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
Analgesic impact of intra-operative opioids vs. opioid-free anaesthesia: a systematic review and meta-analysis.
Frauenknecht J, Kirkham KR, Jacot-Guillarmod A, Albrecht E
Anaesthesia 2019 May;74(5):651-662. Epub 2019 Feb 25 doi: 10.1111/anae.14582. PMID: 30802933
Perioperative intravenous ketamine for acute postoperative pain in adults.
Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, Kontinen V
Cochrane Database Syst Rev 2018 Dec 20;12(12):CD012033. doi: 10.1002/14651858.CD012033.pub4. PMID: 30570761Free PMC Article
Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.
Fletcher D, Martinez V
Br J Anaesth 2014 Jun;112(6):991-1004. doi: 10.1093/bja/aeu137. PMID: 24829420

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