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Meningoencephalitis caused by human herpes simplex virus

MedGen UID:
5536
•Concept ID:
C0019385
•
Disease or Syndrome
Synonyms: Herpes Simplex Meningoencephalitides; Herpes Simplex Meningoencephalitis; Herpetic Meningoencephalitides; Herpetic Meningoencephalitis; Meningoencephalitides, Herpes Simplex; Meningoencephalitides, Herpetic; Meningoencephalitis, Herpes Simplex; Meningoencephalitis, Herpes Simplex Virus; Meningoencephalitis, Herpetic
SNOMED CT: Herpetic meningoencephalitis (9678009); Meningoencephalitis caused by human herpes simplex virus (9678009)

Professional guidelines

PubMed

Role of the virology laboratory in diagnosis and management of patients with central nervous system disease.
Chonmaitree T, Baldwin CD, Lucia HL
Clin Microbiol Rev 1989 Jan;2(1):1-14. doi: 10.1128/CMR.2.1.1. PMID: 2644021Free PMC Article
Herpes simplex virus encephalitis. Diagnostic and treatment considerations.
Griffith JF, Ch'ien LT
Med Clin North Am 1983 Sep;67(5):991-1008. doi: 10.1016/s0025-7125(16)31163-4. PMID: 6194389

Recent clinical studies

Etiology

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.
Li TH, Lai CC, Wang WH, Chen WS, Tsao YP, Tsai CY, Chang YS
Ann Rheum Dis 2019 Jul;78(7):941-946. Epub 2019 Apr 6 doi: 10.1136/annrheumdis-2018-214844. PMID: 30954968
Secular Trends in Infection-Related Mortality after Kidney Transplantation.
Kinnunen S, Karhapää P, Juutilainen A, Finne P, Helanterä I
Clin J Am Soc Nephrol 2018 May 7;13(5):755-762. Epub 2018 Apr 5 doi: 10.2215/CJN.11511017. PMID: 29622669Free PMC Article
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Aphasia and herpes virus encephalitis: a case study.
Soares-Ishigaki EC, Cera ML, Pieri A, Ortiz KZ
Sao Paulo Med J 2012;130(5):336-41. doi: 10.1590/s1516-31802012000500011. PMID: 23174874Free PMC Article
Herpes simplex virus encephalitis. Diagnostic and treatment considerations.
Griffith JF, Ch'ien LT
Med Clin North Am 1983 Sep;67(5):991-1008. doi: 10.1016/s0025-7125(16)31163-4. PMID: 6194389

Diagnosis

Evaluation of the Novel CE-IVD-Marked Multiplex PCR QIAstat-Dx Meningitis/Encephalitis Panel.
Humisto A, Antikainen J, Holma T, Jarva H, Toivonen A, Loginov R, Mannonen L
Microbiol Spectr 2023 Jun 15;11(3):e0514422. Epub 2023 Apr 12 doi: 10.1128/spectrum.05144-22. PMID: 37042772Free PMC Article
Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review.
Araújo PSR, Silva Júnior MLM, Tenório M, Santos FGTD
J Infect Public Health 2019 Jan-Feb;12(1):97-100. Epub 2018 Apr 24 doi: 10.1016/j.jiph.2018.04.010. PMID: 29703710
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Herpes simplex virus infection, with particular reference to the progression and complications of primary herpetic gingivostomatitis.
Kolokotronis A, Doumas S
Clin Microbiol Infect 2006 Mar;12(3):202-11. doi: 10.1111/j.1469-0691.2005.01336.x. PMID: 16451405
Herpes simplex virus encephalitis. Diagnostic and treatment considerations.
Griffith JF, Ch'ien LT
Med Clin North Am 1983 Sep;67(5):991-1008. doi: 10.1016/s0025-7125(16)31163-4. PMID: 6194389

Therapy

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.
Li TH, Lai CC, Wang WH, Chen WS, Tsao YP, Tsai CY, Chang YS
Ann Rheum Dis 2019 Jul;78(7):941-946. Epub 2019 Apr 6 doi: 10.1136/annrheumdis-2018-214844. PMID: 30954968
Secular Trends in Infection-Related Mortality after Kidney Transplantation.
Kinnunen S, Karhapää P, Juutilainen A, Finne P, Helanterä I
Clin J Am Soc Nephrol 2018 May 7;13(5):755-762. Epub 2018 Apr 5 doi: 10.2215/CJN.11511017. PMID: 29622669Free PMC Article
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
HSV-2 meningoencephalitis in an immunocompetent young man: what is the pathogenesis and what is the treatment?
Fernandez-Gerlinger M, Greffe S, Meffre A, Grenet J, Au S, Bojanova M, Rouveix E, Rozenberg F
J Clin Virol 2015 Aug;69:40-3. Epub 2015 Jun 3 doi: 10.1016/j.jcv.2015.05.027. PMID: 26209376
Herpes simplex virus encephalitis. Diagnostic and treatment considerations.
Griffith JF, Ch'ien LT
Med Clin North Am 1983 Sep;67(5):991-1008. doi: 10.1016/s0025-7125(16)31163-4. PMID: 6194389

Prognosis

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.
Li TH, Lai CC, Wang WH, Chen WS, Tsao YP, Tsai CY, Chang YS
Ann Rheum Dis 2019 Jul;78(7):941-946. Epub 2019 Apr 6 doi: 10.1136/annrheumdis-2018-214844. PMID: 30954968
Secular Trends in Infection-Related Mortality after Kidney Transplantation.
Kinnunen S, Karhapää P, Juutilainen A, Finne P, Helanterä I
Clin J Am Soc Nephrol 2018 May 7;13(5):755-762. Epub 2018 Apr 5 doi: 10.2215/CJN.11511017. PMID: 29622669Free PMC Article
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Viral infections of the central nervous system in Spain: a prospective study.
de Ory F, Avellón A, Echevarría JE, Sánchez-Seco MP, Trallero G, Cabrerizo M, Casas I, Pozo F, Fedele G, Vicente D, Pena MJ, Moreno A, Niubo J, Rabella N, Rubio G, Pérez-Ruiz M, Rodríguez-Iglesias M, Gimeno C, Eiros JM, Melón S, Blasco M, López-Miragaya I, Varela E, Martinez-Sapiña A, Rodríguez G, Marcos MÁ, Gegúndez MI, Cilla G, Gabilondo I, Navarro JM, Torres J, Aznar C, Castellanos A, Guisasola ME, Negredo AI, Tenorio A, Vázquez-Morón S
J Med Virol 2013 Mar;85(3):554-62. Epub 2012 Dec 12 doi: 10.1002/jmv.23470. PMID: 23239485
Herpes simplex virus encephalitis. Diagnostic and treatment considerations.
Griffith JF, Ch'ien LT
Med Clin North Am 1983 Sep;67(5):991-1008. doi: 10.1016/s0025-7125(16)31163-4. PMID: 6194389

Clinical prediction guides

An improved animal model for herpesvirus encephalitis in humans.
Sehl J, Hölper JE, Klupp BG, Baumbach C, Teifke JP, Mettenleiter TC
PLoS Pathog 2020 Mar;16(3):e1008445. Epub 2020 Mar 30 doi: 10.1371/journal.ppat.1008445. PMID: 32226043Free PMC Article
Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.
Xing XW, Zhang JT, Ma YB, Chen XY, Wu L, Wang XL, Wang HF, Wang RF, Yang F, Yu SY
Eur Neurol 2018;80(5-6):283-288. Epub 2019 Feb 14 doi: 10.1159/000497319. PMID: 30763937
The spectrum of aseptic central nervous system infections in southern Germany - demographic, clinical and laboratory findings.
Kaminski M, Grummel V, Hoffmann D, Berthele A, Hemmer B
Eur J Neurol 2017 Aug;24(8):1062-1070. Epub 2017 Jun 21 doi: 10.1111/ene.13335. PMID: 28636287
Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Immunological diagnosis in viral infections of the central nervous system: course of antibody titres against homo- and heterologous viruses.
Dennin RH, Herb E
Med Microbiol Immunol 1989;178(5):255-68. doi: 10.1007/BF00191060. PMID: 2550755

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