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Hemosiderosis

MedGen UID:
42409
•Concept ID:
C0019114
•
Disease or Syndrome
Synonym: Hemosideroses
SNOMED CT: Hemosiderosis (39011001)
 
Monarch Initiative: MONDO:0001436

Definition

Accumulation of iron in internal organs. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemosiderosis

Professional guidelines

PubMed

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment.
Murphy CJ, Oudit GY
J Card Fail 2010 Nov;16(11):888-900. Epub 2010 Jul 3 doi: 10.1016/j.cardfail.2010.05.009. PMID: 21055653

Recent clinical studies

Etiology

Trial of Solanezumab in Preclinical Alzheimer's Disease.
Sperling RA, Donohue MC, Raman R, Rafii MS, Johnson K, Masters CL, van Dyck CH, Iwatsubo T, Marshall GA, Yaari R, Mancini M, Holdridge KC, Case M, Sims JR, Aisen PS; A4 Study Team
N Engl J Med 2023 Sep 21;389(12):1096-1107. Epub 2023 Jul 17 doi: 10.1056/NEJMoa2305032. PMID: 37458272Free PMC Article
Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.
Ostrowitzki S, Bittner T, Sink KM, Mackey H, Rabe C, Honig LS, Cassetta E, Woodward M, Boada M, van Dyck CH, Grimmer T, Selkoe DJ, Schneider A, Blondeau K, Hu N, Quartino A, Clayton D, Dolton M, Dang Y, Ostaszewski B, Sanabria-Bohórquez SM, Rabbia M, Toth B, Eichenlaub U, Smith J, Honigberg LA, Doody RS
JAMA Neurol 2022 Nov 1;79(11):1113-1121. doi: 10.1001/jamaneurol.2022.2909. PMID: 36121669Free PMC Article
Idiopathic pulmonary hemosiderosis: A state of the art review.
Saha BK
Respir Med 2021 Jan;176:106234. Epub 2020 Nov 17 doi: 10.1016/j.rmed.2020.106234. PMID: 33246295
Liver disease and heart failure.
Correale M, Tricarico L, Leopizzi A, Mallardi A, Mazzeo P, Tucci S, Grazioli D, Di Biase M, Brunetti ND
Panminerva Med 2020 Mar;62(1):26-37. Epub 2019 Oct 25 doi: 10.23736/S0031-0808.19.03768-6. PMID: 31670498
Role of Cardiac Magnetic Resonance in the Diagnosis and Prognosis of Nonischemic Cardiomyopathy.
Patel AR, Kramer CM
JACC Cardiovasc Imaging 2017 Oct;10(10 Pt A):1180-1193. doi: 10.1016/j.jcmg.2017.08.005. PMID: 28982571Free PMC Article

Diagnosis

Idiopathic pulmonary haemosiderosis.
Gupta L, Semple T, Padley S, Bossley CJ
BMJ Case Rep 2024 Jun 27;17(6) doi: 10.1136/bcr-2024-261171. PMID: 38937263
Gastrointestinal Hemosiderosis.
Habash N, Absah I
J Pediatr Gastroenterol Nutr 2021 Oct 1;73(4):e105. doi: 10.1097/MPG.0000000000003215. PMID: 34183616
Idiopathic pulmonary hemosiderosis: A state of the art review.
Saha BK
Respir Med 2021 Jan;176:106234. Epub 2020 Nov 17 doi: 10.1016/j.rmed.2020.106234. PMID: 33246295
Hemosiderotic dermatofibroma.
Villarreal DJ, Luz AT, Buçard AM, Abreu L, Cuzzi T
An Bras Dermatol 2017 Jan-Feb;92(1):92-94. doi: 10.1590/abd1806-4841.20173563. PMID: 28225963Free PMC Article
Restrictive cardiomyopathies.
Nihoyannopoulos P, Dawson D
Eur J Echocardiogr 2009 Dec;10(8):iii23-33. doi: 10.1093/ejechocard/jep156. PMID: 19889655

Therapy

Idiopathic pulmonary haemosiderosis.
Gupta L, Semple T, Padley S, Bossley CJ
BMJ Case Rep 2024 Jun 27;17(6) doi: 10.1136/bcr-2024-261171. PMID: 38937263
Trial of Solanezumab in Preclinical Alzheimer's Disease.
Sperling RA, Donohue MC, Raman R, Rafii MS, Johnson K, Masters CL, van Dyck CH, Iwatsubo T, Marshall GA, Yaari R, Mancini M, Holdridge KC, Case M, Sims JR, Aisen PS; A4 Study Team
N Engl J Med 2023 Sep 21;389(12):1096-1107. Epub 2023 Jul 17 doi: 10.1056/NEJMoa2305032. PMID: 37458272Free PMC Article
Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.
Ostrowitzki S, Bittner T, Sink KM, Mackey H, Rabe C, Honig LS, Cassetta E, Woodward M, Boada M, van Dyck CH, Grimmer T, Selkoe DJ, Schneider A, Blondeau K, Hu N, Quartino A, Clayton D, Dolton M, Dang Y, Ostaszewski B, Sanabria-Bohórquez SM, Rabbia M, Toth B, Eichenlaub U, Smith J, Honigberg LA, Doody RS
JAMA Neurol 2022 Nov 1;79(11):1113-1121. doi: 10.1001/jamaneurol.2022.2909. PMID: 36121669Free PMC Article
Idiopathic pulmonary hemosiderosis: A state of the art review.
Saha BK
Respir Med 2021 Jan;176:106234. Epub 2020 Nov 17 doi: 10.1016/j.rmed.2020.106234. PMID: 33246295
Deferasirox.
Stumpf JL
Am J Health Syst Pharm 2007 Mar 15;64(6):606-16. doi: 10.2146/ajhp060405. PMID: 17353569

Prognosis

Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Idiopathic pulmonary hemosiderosis: A state of the art review.
Saha BK
Respir Med 2021 Jan;176:106234. Epub 2020 Nov 17 doi: 10.1016/j.rmed.2020.106234. PMID: 33246295
Diagnostic histochemistry in hepatic pathology.
Iezzoni JC
Semin Diagn Pathol 2018 Nov;35(6):381-389. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.003. PMID: 30409459
Role of Cardiac Magnetic Resonance in the Diagnosis and Prognosis of Nonischemic Cardiomyopathy.
Patel AR, Kramer CM
JACC Cardiovasc Imaging 2017 Oct;10(10 Pt A):1180-1193. doi: 10.1016/j.jcmg.2017.08.005. PMID: 28982571Free PMC Article
Vitreous Hemorrhage.
Spraul CW, Grossniklaus HE
Surv Ophthalmol 1997 Jul-Aug;42(1):3-39. doi: 10.1016/s0039-6257(97)84041-6. PMID: 9265701

Clinical prediction guides

Trial of Solanezumab in Preclinical Alzheimer's Disease.
Sperling RA, Donohue MC, Raman R, Rafii MS, Johnson K, Masters CL, van Dyck CH, Iwatsubo T, Marshall GA, Yaari R, Mancini M, Holdridge KC, Case M, Sims JR, Aisen PS; A4 Study Team
N Engl J Med 2023 Sep 21;389(12):1096-1107. Epub 2023 Jul 17 doi: 10.1056/NEJMoa2305032. PMID: 37458272Free PMC Article
Vitreous hemorrhage - Causes, diagnosis, and management.
Shaikh N, Srishti R, Khanum A, Thirumalesh MB, Dave V, Arora A, Bansal R, Surve A, Azad S, Kumar V
Indian J Ophthalmol 2023 Jan;71(1):28-38. doi: 10.4103/ijo.IJO_928_22. PMID: 36588205Free PMC Article
Idiopathic pulmonary hemosiderosis: A state of the art review.
Saha BK
Respir Med 2021 Jan;176:106234. Epub 2020 Nov 17 doi: 10.1016/j.rmed.2020.106234. PMID: 33246295
Diagnostic histochemistry in hepatic pathology.
Iezzoni JC
Semin Diagn Pathol 2018 Nov;35(6):381-389. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.003. PMID: 30409459
Role of Cardiac Magnetic Resonance in the Diagnosis and Prognosis of Nonischemic Cardiomyopathy.
Patel AR, Kramer CM
JACC Cardiovasc Imaging 2017 Oct;10(10 Pt A):1180-1193. doi: 10.1016/j.jcmg.2017.08.005. PMID: 28982571Free PMC Article

Recent systematic reviews

Treatment of Iron-Induced Cutaneous Hyperpigmentation With Energy-Based Devices.
Sharma AN, Golbari NM, Grushchak S, Andrade AR, Zachary CB
Lasers Surg Med 2024 Sep;56(7):625-631. Epub 2024 Jul 15 doi: 10.1002/lsm.23825. PMID: 39010642
Nonspecific interstitial pneumonia pattern is a frequent finding in patients with post-acute COVID-19 syndrome treated with bilateral orthotopic lung transplantation: current best evidence.
Mortazavi S, de Peralta-Venturina M, Marchevsky AM
Hum Pathol 2023 Nov;141:90-101. Epub 2023 Jun 24 doi: 10.1016/j.humpath.2023.06.008. PMID: 37364827Free PMC Article
Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: A meta-analysis.
Charidimou A, Boulouis G, Greenberg SM, Viswanathan A
Neurology 2019 Dec 10;93(24):e2192-e2202. Epub 2019 Nov 15 doi: 10.1212/WNL.0000000000008590. PMID: 31732564Free PMC Article
Cardiac complications and iron overload in beta thalassemia major patients-a systematic review and meta-analysis.
Koohi F, Kazemi T, Miri-Moghaddam E
Ann Hematol 2019 Jun;98(6):1323-1331. Epub 2019 Feb 7 doi: 10.1007/s00277-019-03618-w. PMID: 30729283
Idiopathic pulmonary hemosiderosis in adults: review of cases reported in the latest 15 years.
Chen XY, Sun JM, Huang XJ
Clin Respir J 2017 Nov;11(6):677-681. Epub 2016 Mar 14 doi: 10.1111/crj.12440. PMID: 26692115

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