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Gynandroblastoma

MedGen UID:
5403
•Concept ID:
C0018413
•
Neoplastic Process
Synonym: Gynandroblastomas
SNOMED CT: Gynandroblastoma (26735007)

Definition

A sex cord-gonadal stromal tumor, composed of cells of both the OVARY and the TESTIS. It produces both male and female GONADAL STEROID HORMONES. [from MeSH]

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
Schultz KAP, Harris AK, Finch M, Dehner LP, Brown JB, Gershenson DM, Young RH, Field A, Yu W, Turner J, Cost NG, Schneider DT, Stewart DR, Frazier AL, Messinger Y, Hill DA
Gynecol Oncol 2017 Dec;147(3):521-527. Epub 2017 Oct 14 doi: 10.1016/j.ygyno.2017.09.034. PMID: 29037807Free PMC Article

Recent clinical studies

Etiology

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists.
Horta M, Cunha TM
Diagn Interv Radiol 2015 Jul-Aug;21(4):277-86. doi: 10.5152/dir.2015.34414. PMID: 26054417Free PMC Article
Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718
Gynandroblastoma with elements resembling juvenile granulosa cell tumor.
Broshears JR, Roth LM
Int J Gynecol Pathol 1997 Oct;16(4):387-91. doi: 10.1097/00004347-199710000-00016. PMID: 9421080
Masculinizing ovarian tumors.
Ireland K, Woodruff JD
Obstet Gynecol Surv 1976 Feb;31(2):83-111. doi: 10.1097/00006254-197602000-00001. PMID: 1107904

Diagnosis

Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
Gynandroblastoma with a Juvenile Granulosa Cell Component in an Adolescent: Case Report and Literature Review.
Takeda A, Watanabe K, Hayashi S, Imoto S, Nakamura H
J Pediatr Adolesc Gynecol 2017 Apr;30(2):251-255. Epub 2016 Oct 15 doi: 10.1016/j.jpag.2016.10.005. PMID: 27751908
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review.
Tian W, Wang Y, Zhang H, Liu G, Ma X, Xue F
J Low Genit Tract Dis 2013 Jul;17(3):335-9. doi: 10.1097/LGT.0b013e3182702796. PMID: 23552209

Therapy

Sertoli-Leydig Cell Tumors of the Ovary With Follicular Differentiation Often Resembling Juvenile Granulosa Cell Tumor: A Report of 38 Cases Including Comments on Sex Cord-Stromal Tumors of Mixed Forms (So-called Gynandroblastoma).
Ordulu Z, Young RH
Am J Surg Pathol 2021 Jan;45(1):59-67. doi: 10.1097/PAS.0000000000001544. PMID: 32815828

Prognosis

Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists.
Horta M, Cunha TM
Diagn Interv Radiol 2015 Jul-Aug;21(4):277-86. doi: 10.5152/dir.2015.34414. PMID: 26054417Free PMC Article
Masculinizing ovarian tumors.
Ireland K, Woodruff JD
Obstet Gynecol Surv 1976 Feb;31(2):83-111. doi: 10.1097/00006254-197602000-00001. PMID: 1107904

Clinical prediction guides

Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718
Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry.
Schultz KA, Pacheco MC, Yang J, Williams GM, Messinger Y, Hill DA, Dehner LP, Priest JR
Gynecol Oncol 2011 Aug;122(2):246-50. Epub 2011 Apr 17 doi: 10.1016/j.ygyno.2011.03.024. PMID: 21501861Free PMC Article
Gynandroblastoma of the ovary: a case report with an immunohistochemical and ultrastructural study.
Fukunaga M, Endo Y, Ushigome S
Virchows Arch 1997 Jan;430(1):77-82. doi: 10.1007/BF01008020. PMID: 9037319
Hormone studies in a gynandroblastoma.
Cantor B, Pierson KK, Kalra PS
Fertil Steril 1978 Jun;29(6):681-5. doi: 10.1016/s0015-0282(16)43345-5. PMID: 658481
HISTOCHEMICAL OBSERVATIONS ON MUCINS IN HUMAN OVARIAN NEOPLASMS.
GARCIA-BUNUEL R, MONIS B
Cancer 1964 Sep;17:1108-18. doi: 10.1002/1097-0142(196409)17:9<1108::aid-cncr2820170903>3.0.co;2-8. PMID: 14211782

Recent systematic reviews

Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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