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Generalized atherosclerosis

MedGen UID:
4866
•Concept ID:
C0017327
•
Disease or Syndrome
Synonyms: generalised and unspecified atherosclerosis; generalized and unspecified atherosclerosis; Generalized Atherosclerosis; generalized atherosclerosis
SNOMED CT: Generalized atherosclerosis (39823006)
 
Monarch Initiative: MONDO:0002275

Definition

Atherosclerosis that is not localized. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGeneralized atherosclerosis

Professional guidelines

PubMed

Selection of Patients for Angioplasty for Treatment of Atherosclerotic Renovascular Disease: Predicting Responsive Patients.
Mishima E, Suzuki T, Ito S
Am J Hypertens 2020 Apr 29;33(5):391-401. doi: 10.1093/ajh/hpaa016. PMID: 31996895
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Evidence for maximal treatment of atherosclerosis: drastic reduction of cholesterol and fibrinogen restores vascular homeostasis.
Jaeger BR
Ther Apher 2001 Jun;5(3):207-11. PMID: 11467757

Recent clinical studies

Etiology

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Exercise and carotid atherosclerosis.
Kadoglou NP, Iliadis F, Liapis CD
Eur J Vasc Endovasc Surg 2008 Mar;35(3):264-72. Epub 2007 Nov 7 doi: 10.1016/j.ejvs.2007.08.022. PMID: 17988901
Cytokines in aging and exercise.
Pedersen BK, Bruunsgaard H, Ostrowski K, Krabbe K, Hansen H, Krzywkowski K, Toft A, Søndergaard SR, Petersen EW, Ibfelt T, Schjerling P
Int J Sports Med 2000 May;21 Suppl 1:S4-9. doi: 10.1055/s-2000-1444. PMID: 10893017
Diabetes in the elderly population.
Khan MA, Collins AJ, Keane WF
Adv Ren Replace Ther 2000 Jan;7(1):32-51. doi: 10.1016/s1073-4449(00)70004-5. PMID: 10672916

Diagnosis

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Diabetes and peripheral vascular disease.
Huysman E, Mathieu C
Acta Chir Belg 2009 Oct;109(5):587-94. doi: 10.1080/00015458.2009.11680493. PMID: 19994800
Unusual causes of mesenteric ischemia.
Krupski WC, Selzman CH, Whitehill TA
Surg Clin North Am 1997 Apr;77(2):471-502. doi: 10.1016/s0039-6109(05)70562-4. PMID: 9146726
Acute mesenteric ischemia.
Mishima Y
Jpn J Surg 1988 Nov;18(6):615-9. doi: 10.1007/BF02471520. PMID: 3246774

Therapy

Renal Artery Stenosis: New Findings from the CORAL Trial.
Gupta R, Assiri S, Cooper CJ
Curr Cardiol Rep 2017 Sep;19(9):75. doi: 10.1007/s11886-017-0894-2. PMID: 28752274
Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Diabetes and peripheral vascular disease.
Huysman E, Mathieu C
Acta Chir Belg 2009 Oct;109(5):587-94. doi: 10.1080/00015458.2009.11680493. PMID: 19994800
Androgens and cardiovascular disease.
Liu PY, Death AK, Handelsman DJ
Endocr Rev 2003 Jun;24(3):313-40. doi: 10.1210/er.2003-0005. PMID: 12788802

Prognosis

International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches.
Saba L, Antignani PL, Gupta A, Cau R, Paraskevas KI, Poredos P, Wasserman B, Kamel H, Avgerinos ED, Salgado R, Caobelli F, Aluigi L, Savastano L, Brown M, Hatsukami T, Hussein E, Suri JS, Mansilha A, Wintermark M, Staub D, Montequin JF, Rodriguez RTT, Balu N, Pitha J, Kooi ME, Lal BK, Spence JD, Lanzino G, Marcus HS, Mancini M, Chaturvedi S, Blinc A
Atherosclerosis 2022 Aug;354:23-40. Epub 2022 Jun 28 doi: 10.1016/j.atherosclerosis.2022.06.1014. PMID: 35816927
Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Aortic sclerosis and mitral annulus calcification: a window to vascular atherosclerosis?
Lazaros G, Toutouzas K, Drakopoulou M, Boudoulas H, Stefanadis C, Rajamannan N
Expert Rev Cardiovasc Ther 2013 Jul;11(7):863-77. doi: 10.1586/14779072.2013.811978. PMID: 23895030
Asymptomatic carotid bruit.
Fareleira F, Julião M, Roque A, Carneiro AV
Rev Port Cardiol 2005 Feb;24(2):285-94. PMID: 15861909

Clinical prediction guides

Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Association between renal vasculature changes and generalized atherosclerosis: an autopsy survey.
Iwakiri T, Sato Y, Matsuura Y, Hatakeyama K, Marutsuka K, Yamashita A, Fujimoto S, Kitamura K, Asada Y
J Atheroscler Thromb 2014;21(2):99-107. Epub 2013 Oct 5 doi: 10.5551/jat.19869. PMID: 24096900
Aortic sclerosis and mitral annulus calcification: a window to vascular atherosclerosis?
Lazaros G, Toutouzas K, Drakopoulou M, Boudoulas H, Stefanadis C, Rajamannan N
Expert Rev Cardiovasc Ther 2013 Jul;11(7):863-77. doi: 10.1586/14779072.2013.811978. PMID: 23895030
Asymptomatic carotid bruit.
Fareleira F, Julião M, Roque A, Carneiro AV
Rev Port Cardiol 2005 Feb;24(2):285-94. PMID: 15861909
Androgens and cardiovascular disease.
Liu PY, Death AK, Handelsman DJ
Endocr Rev 2003 Jun;24(3):313-40. doi: 10.1210/er.2003-0005. PMID: 12788802

Recent systematic reviews

Complex atheromatous plaques in the descending aorta and the risk of stroke: a systematic review and meta-analysis.
Katsanos AH, Giannopoulos S, Kosmidou M, Voumvourakis K, Parissis JT, Kyritsis AP, Tsivgoulis G
Stroke 2014 Jun;45(6):1764-70. Epub 2014 May 1 doi: 10.1161/STROKEAHA.114.005190. PMID: 24788969
Exercise and carotid atherosclerosis.
Kadoglou NP, Iliadis F, Liapis CD
Eur J Vasc Endovasc Surg 2008 Mar;35(3):264-72. Epub 2007 Nov 7 doi: 10.1016/j.ejvs.2007.08.022. PMID: 17988901

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