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Fuchs heterochromic iridocyclitis(FHI)

MedGen UID:
507742
•Concept ID:
C0016782
•
Disease or Syndrome
Synonyms: FHI; Fuchs' heterochromic uveitis
SNOMED CT: Fuchs' heterochromic cyclitis (11226001); Fuchs' heterochromic uveitis (11226001); Fuchs' heterochromic iridocyclitis (11226001); Fuchs uveitis syndrome (11226001)
 
Monarch Initiative: MONDO:0016989
Orphanet: ORPHA263479

Definition

Fuchs heterochromic iridocyclitis (FHI) is an ocular disease of unknown etiology occurring in a very small percentage (0.5-6.2%) of uvietis cases, characterized by diffuse iris heterochromia or atrophy, keratic precipitates in the absence of synechiae, and in some cases evolving to glaucoma and vitreous opacities. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFuchs heterochromic iridocyclitis
Follow this link to review classifications for Fuchs heterochromic iridocyclitis in Orphanet.

Professional guidelines

PubMed

Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis.
You YA, Wu Y, Hu S
Graefes Arch Clin Exp Ophthalmol 2013 Jul;251(7):1785-90. Epub 2013 Mar 22 doi: 10.1007/s00417-013-2312-9. PMID: 23519886
Management of chronic pediatric uveitis.
Levy-Clarke GA, Nussenblatt RB, Smith JA
Curr Opin Ophthalmol 2005 Oct;16(5):281-8. doi: 10.1097/01.icu.0000177414.79030.32. PMID: 16175040
Treatment and prognosis of secondary glaucoma in Fuchs' heterochromic iridocyclitis.
La Hey E, de Vries J, Langerhorst CT, Baarsma GS, Kijlstra A
Am J Ophthalmol 1993 Sep 15;116(3):327-40. doi: 10.1016/s0002-9394(14)71350-9. PMID: 8357057

Recent clinical studies

Etiology

Association of Fuchs Heterochromic Iridocyclitis with Multiple Sclerosis.
Brichová M, Lízrová JP, Heissigerová J, Jeníčková D, Klímová A, Svozílková P
Cesk Slov Oftalmol 2024;80(Ahead of print):1001-1005. doi: 10.31348/2024/17. PMID: 38538292
Cytokine Changes in the Aqueous Humor in Rubella-Related Fuchs Heterochromic Iridocyclitis.
Mao Y, Lin S, Zhu C, Liu X, Wu H, Ou S
Dis Markers 2022;2022:8906752. Epub 2022 Feb 7 doi: 10.1155/2022/8906752. PMID: 35178133Free PMC Article
Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis.
Sravani NG, Mohamed A, Chaurasia S, Durgam SS, Murthy SI
Indian J Ophthalmol 2020 Mar;68(3):447-449. doi: 10.4103/ijo.IJO_869_19. PMID: 32056999Free PMC Article
Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C.
Esfandiari H, Loewen NA, Hassanpour K, Fatourechi A, Yazdani S, Wang C, Yaseri M, Pakravan M
F1000Res 2018;7:876. Epub 2018 Jun 22 doi: 10.12688/f1000research.15244.2. PMID: 30410728Free PMC Article
Fuchs' heterochromic iridocyclitis: a review of 26 cases.
Velilla S, Dios E, Herreras JM, Calonge M
Ocul Immunol Inflamm 2001 Sep;9(3):169-75. doi: 10.1076/ocii.9.3.169.3964. PMID: 11815885

Diagnosis

Association of Fuchs Heterochromic Iridocyclitis with Multiple Sclerosis.
Brichová M, Lízrová JP, Heissigerová J, Jeníčková D, Klímová A, Svozílková P
Cesk Slov Oftalmol 2024;80(Ahead of print):1001-1005. doi: 10.31348/2024/17. PMID: 38538292
Optic coherence tomography angiography findings in fuchs heterochromic iridocyclitis.
Degirmenci C, Yarimada S, Guven Yilmaz S, Nalcaci S, Ates H, Afrashi F
Int Ophthalmol 2022 Aug;42(8):2519-2524. Epub 2022 May 27 doi: 10.1007/s10792-022-02299-1. PMID: 35624335
Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis.
Sravani NG, Mohamed A, Chaurasia S, Durgam SS, Murthy SI
Indian J Ophthalmol 2020 Mar;68(3):447-449. doi: 10.4103/ijo.IJO_869_19. PMID: 32056999Free PMC Article
Fuchs heterochromic iridocyclitis and the rubella virus.
Liu Y, Takusagawa HL, Chen TC, Pasquale LR
Int Ophthalmol Clin 2011 Fall;51(4):1-12. doi: 10.1097/IIO.0b013e31822d6923. PMID: 21897135
Doyne lecture. Heterochromic iridocyclitis.
O'Connor GR
Trans Ophthalmol Soc U K (1962) 1985;104 ( Pt 3):219-31. PMID: 3895609

Therapy

Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C.
Esfandiari H, Loewen NA, Hassanpour K, Fatourechi A, Yazdani S, Wang C, Yaseri M, Pakravan M
F1000Res 2018;7:876. Epub 2018 Jun 22 doi: 10.12688/f1000research.15244.2. PMID: 30410728Free PMC Article
Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis.
You YA, Wu Y, Hu S
Graefes Arch Clin Exp Ophthalmol 2013 Jul;251(7):1785-90. Epub 2013 Mar 22 doi: 10.1007/s00417-013-2312-9. PMID: 23519886
Epidemiologic relationship between fuchs heterochromic iridocyclitis and the United States rubella vaccination program.
Birnbaum AD, Tessler HH, Schultz KL, Farber MD, Gao W, Lin P, Oh F, Goldstein DA
Am J Ophthalmol 2007 Sep;144(3):424-428. Epub 2007 Jul 13 doi: 10.1016/j.ajo.2007.05.026. PMID: 17631266
Uveitis in childhood.
Kadayifçilar S, Eldem B, Tumer B
J Pediatr Ophthalmol Strabismus 2003 Nov-Dec;40(6):335-40. doi: 10.3928/0191-3913-20031101-06. PMID: 14655981
Doyne lecture. Heterochromic iridocyclitis.
O'Connor GR
Trans Ophthalmol Soc U K (1962) 1985;104 ( Pt 3):219-31. PMID: 3895609

Prognosis

The outcome of initial mitomycin C-augmented trabeculectomy with subconjunctival bevacizumab in the management of secondary glaucoma associated with Fuchs heterochromic iridocyclitis.
Elgin U, Sen E, Ozdemir K, Ozdal P, Berker N
Int Ophthalmol 2020 Apr;40(4):795-802. Epub 2019 Dec 3 doi: 10.1007/s10792-019-01240-3. PMID: 31792855
Predictive Factors of Intraocular Pressure Level Evolution Over Time and Glaucoma Severity in Fuchs' Heterochromic Iridocyclitis.
Touhami S, Vanier A, Rosati A, Bojanova M, Benromdhane B, Lehoang P, Rozenberg F, Bodaghi B
Invest Ophthalmol Vis Sci 2019 Jun 3;60(7):2399-2405. doi: 10.1167/iovs.18-24597. PMID: 31157832
Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis.
Toniolo JT, Hall AJ, Smith JG, Levy J, Lim LL
Ocul Immunol Inflamm 2017 Dec;25(6):753-759. Epub 2016 Aug 5 doi: 10.1080/09273948.2016.1199712. PMID: 27494676
Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis.
You YA, Wu Y, Hu S
Graefes Arch Clin Exp Ophthalmol 2013 Jul;251(7):1785-90. Epub 2013 Mar 22 doi: 10.1007/s00417-013-2312-9. PMID: 23519886
Treatment and prognosis of secondary glaucoma in Fuchs' heterochromic iridocyclitis.
La Hey E, de Vries J, Langerhorst CT, Baarsma GS, Kijlstra A
Am J Ophthalmol 1993 Sep 15;116(3):327-40. doi: 10.1016/s0002-9394(14)71350-9. PMID: 8357057

Clinical prediction guides

Cytokine Changes in the Aqueous Humor in Rubella-Related Fuchs Heterochromic Iridocyclitis.
Mao Y, Lin S, Zhu C, Liu X, Wu H, Ou S
Dis Markers 2022;2022:8906752. Epub 2022 Feb 7 doi: 10.1155/2022/8906752. PMID: 35178133Free PMC Article
Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis.
Sravani NG, Mohamed A, Chaurasia S, Durgam SS, Murthy SI
Indian J Ophthalmol 2020 Mar;68(3):447-449. doi: 10.4103/ijo.IJO_869_19. PMID: 32056999Free PMC Article
Fuchs' heterochromic iridocyclitis: a review of 26 cases.
Velilla S, Dios E, Herreras JM, Calonge M
Ocul Immunol Inflamm 2001 Sep;9(3):169-75. doi: 10.1076/ocii.9.3.169.3964. PMID: 11815885
Fuchs' heterochromic iridocyclitis revisited.
Fearnley IR, Rosenthal AR
Acta Ophthalmol Scand 1995 Apr;73(2):166-70. doi: 10.1111/j.1600-0420.1995.tb00661.x. PMID: 7656148
Doyne lecture. Heterochromic iridocyclitis.
O'Connor GR
Trans Ophthalmol Soc U K (1962) 1985;104 ( Pt 3):219-31. PMID: 3895609

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