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Fascioliasis

MedGen UID:
41969
•Concept ID:
C0015652
•
Disease or Syndrome
Synonyms: Fasciola Infection; Fasciola Infections; Fascioliases; Infection, Fasciola; Infections, Fasciola
SNOMED CT: Infection by Fasciola (111922007); Fascioliasis (111922007); Infection caused by Fasciola (111922007)
 
Monarch Initiative: MONDO:0004668

Definition

A parasitic infection that is caused by liver flukes, usually Fasciola hepatica, of sheep, goats, and cattle. Humans become infected by eating uncooked, infested aquatic vegetation (classically watercress). Adult flukes inhabit the bile ducts, gallbladder, and occasionally ectopic sites. Symptoms arise secondary to inflammatory response or obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFascioliasis

Professional guidelines

PubMed

Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures.
Marcos L, Maco V, Terashima A
Expert Rev Anti Infect Ther 2021 Jul;19(7):817-823. Epub 2020 Dec 14 doi: 10.1080/14787210.2021.1858798. PMID: 33267701
Triclabendazole for the treatment of fascioliasis.
Thakare R, Dasgupta A, Chopra S
Drugs Today (Barc) 2019 Dec;55(12):743-752. doi: 10.1358/dot.2019.55.12.3058861. PMID: 31942877
Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection.
Webb CM, Cabada MM
Curr Opin Infect Dis 2018 Oct;31(5):409-414. doi: 10.1097/QCO.0000000000000482. PMID: 30113327

Recent clinical studies

Etiology

Molluscicidal activity of plant alkaloids.
Wszelaki S, Podobiński P, Środoń K
J Appl Toxicol 2023 Dec;43(12):1778-1792. Epub 2023 Apr 1 doi: 10.1002/jat.4466. PMID: 36987554
Liver Fluke-Associated Biliary Tract Cancer.
Prueksapanich P, Piyachaturawat P, Aumpansub P, Ridtitid W, Chaiteerakij R, Rerknimitr R
Gut Liver 2018 May 15;12(3):236-245. doi: 10.5009/gnl17102. PMID: 28783896Free PMC Article
Ecohealth research in Africa: Where from-Where to?
Bergquist R, Brattig NW, Chimbari MJ, Zinsstag J, Utzinger J
Acta Trop 2017 Nov;175:1-8. Epub 2017 Jul 18 doi: 10.1016/j.actatropica.2017.07.015. PMID: 28733024
Mucocutaneous manifestations of helminth infections: Nematodes.
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):929-44; quiz 945-6. doi: 10.1016/j.jaad.2014.11.034. PMID: 26568337
Fasciolosis.
Dietrich CF, Kabaalioglu A, Brunetti E, Richter J
Z Gastroenterol 2015 Apr;53(4):285-90. Epub 2015 Apr 10 doi: 10.1055/s-0034-1385728. PMID: 25860578

Diagnosis

Fasciolosis in India: An overview.
Lalrinkima H, Lalchhandama C, Jacob SS, Raina OK, Lallianchhunga MC
Exp Parasitol 2021 Mar;222:108066. Epub 2021 Jan 12 doi: 10.1016/j.exppara.2021.108066. PMID: 33444570
Human liver flukes.
Harrington D, Lamberton PHL, McGregor A
Lancet Gastroenterol Hepatol 2017 Sep;2(9):680-689. doi: 10.1016/S2468-1253(17)30111-5. PMID: 28786389
Fasciolosis.
Dietrich CF, Kabaalioglu A, Brunetti E, Richter J
Z Gastroenterol 2015 Apr;53(4):285-90. Epub 2015 Apr 10 doi: 10.1055/s-0034-1385728. PMID: 25860578
Human fascioliasis.
Saba R, Korkmaz M, Inan D, Mamikoğlu L, Turhan O, Günseren F, Cevikol C, Kabaalioğlu A
Clin Microbiol Infect 2004 May;10(5):385-7. doi: 10.1111/j.1469-0691.2004.00820.x. PMID: 15113313
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601

Therapy

Fascioliasis.
Mas-Coma S, Valero MA, Bargues MD
Adv Exp Med Biol 2024;1454:157-201. doi: 10.1007/978-3-031-60121-7_5. PMID: 39008266
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
Fasciolosis.
Dietrich CF, Kabaalioglu A, Brunetti E, Richter J
Z Gastroenterol 2015 Apr;53(4):285-90. Epub 2015 Apr 10 doi: 10.1055/s-0034-1385728. PMID: 25860578
Fascioliasis.
Mas-Coma S, Valero MA, Bargues MD
Adv Exp Med Biol 2014;766:77-114. doi: 10.1007/978-1-4939-0915-5_4. PMID: 24903364
Human fascioliasis.
Saba R, Korkmaz M, Inan D, Mamikoğlu L, Turhan O, Günseren F, Cevikol C, Kabaalioğlu A
Clin Microbiol Infect 2004 May;10(5):385-7. doi: 10.1111/j.1469-0691.2004.00820.x. PMID: 15113313

Prognosis

Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma.
Francalanci E, Manciulli T, Bandini G, Blanc P, Bonelli SI, Brunetti E, Gotuzzo E, Cretu CM, Gobbi F, Bartoloni A, Zammarchi L
Acta Parasitol 2023 Dec;68(4):937-941. Epub 2023 Oct 23 doi: 10.1007/s11686-023-00723-9. PMID: 37872438Free PMC Article
Mucocutaneous manifestations of helminth infections: Trematodes and cestodes.
Lupi O, Downing C, Lee M, Bravo F, Giglio P, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):947-57; quiz 957-8. doi: 10.1016/j.jaad.2014.11.035. PMID: 26568338
Mucocutaneous manifestations of helminth infections: Nematodes.
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
J Am Acad Dermatol 2015 Dec;73(6):929-44; quiz 945-6. doi: 10.1016/j.jaad.2014.11.034. PMID: 26568337
Neurological and ocular fascioliasis in humans.
Mas-Coma S, Agramunt VH, Valero MA
Adv Parasitol 2014;84:27-149. doi: 10.1016/B978-0-12-800099-1.00002-8. PMID: 24480313
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601

Clinical prediction guides

Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma.
Francalanci E, Manciulli T, Bandini G, Blanc P, Bonelli SI, Brunetti E, Gotuzzo E, Cretu CM, Gobbi F, Bartoloni A, Zammarchi L
Acta Parasitol 2023 Dec;68(4):937-941. Epub 2023 Oct 23 doi: 10.1007/s11686-023-00723-9. PMID: 37872438Free PMC Article
Human fascioliasis presenting as liver abscess: clinical characteristics and management.
Leerapun A, Puasripun S, Kijdamrongthum P, Thongsawat S
Hepatol Int 2021 Jun;15(3):804-811. Epub 2021 Apr 17 doi: 10.1007/s12072-021-10180-z. PMID: 33866512
Fasciola hepatica-derived molecules as potential immunomodulators.
Corral-Ruiz GM, Sánchez-Torres LE
Acta Trop 2020 Oct;210:105548. Epub 2020 Jun 4 doi: 10.1016/j.actatropica.2020.105548. PMID: 32505597
Association between Liver Fluke Infection and Hepatobiliary Pathological Changes: A Systematic Review and Meta-Analysis.
Xia J, Jiang SC, Peng HJ
PLoS One 2015;10(7):e0132673. Epub 2015 Jul 17 doi: 10.1371/journal.pone.0132673. PMID: 26186510Free PMC Article
Human fascioliasis.
Atalay F, Kirimlioğlu V, Dağli U, Akincioğlu T, Akoğlu M, Seven C
Surg Today 1993;23(4):366-9. doi: 10.1007/BF00309057. PMID: 8318792

Recent systematic reviews

Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis.
Qian MB, Patel C, Palmeirim MS, Wang X, Schindler C, Utzinger J, Zhou XN, Keiser J
Lancet Microbe 2022 Aug;3(8):e616-e624. Epub 2022 Jun 10 doi: 10.1016/S2666-5247(22)00026-X. PMID: 35697047
Human fascioliasis in Africa: A systematic review.
Dermauw V, Muchai J, Al Kappany Y, Fajardo Castaneda AL, Dorny P
PLoS One 2021;16(12):e0261166. Epub 2021 Dec 9 doi: 10.1371/journal.pone.0261166. PMID: 34882738Free PMC Article
Highlights of human ectopic fascioliasis: a systematic review.
Taghipour A, Zaki L, Rostami A, Foroutan M, Ghaffarifar F, Fathi A, Abdoli A
Infect Dis (Lond) 2019 Nov-Dec;51(11-12):785-792. Epub 2019 Sep 11 doi: 10.1080/23744235.2019.1663362. PMID: 31507248
Human and Animal Fascioliasis in Iran: Systematic Review and Meta-analysis.
Bahmaninejad P, Abdi J, Valizadeh R
Infect Disord Drug Targets 2019;19(1):30-35. doi: 10.2174/1871526518666180816102040. PMID: 30113004
Association between Liver Fluke Infection and Hepatobiliary Pathological Changes: A Systematic Review and Meta-Analysis.
Xia J, Jiang SC, Peng HJ
PLoS One 2015;10(7):e0132673. Epub 2015 Jul 17 doi: 10.1371/journal.pone.0132673. PMID: 26186510Free PMC Article

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