U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epidermodysplasia verruciformis(EV)

MedGen UID:
41831
Concept ID:
C0014522
Neoplastic Process
Synonyms: Disease, Lewandowsky-Lutz; Disease, Lutz-Lewandowsky; Epidermodysplasia Verruciformis; Lewandowsky Lutz Disease; Lewandowsky-Lutz Disease; Lutz Lewandowsky Disease; Lutz-Lewandowsky Disease
SNOMED CT: Epidermodysplasia verruciformis (19138001); Lewandowsky-Lutz disease (19138001)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
 
Monarch Initiative: MONDO:0009176
OMIM®: 226400
Orphanet: ORPHA302

Definition

Epidermodysplasia verruciformis (EV) is a rare inherited genodermatosis characterized by chronic infection with human papillomavirus (HPV) leading to polymorphous cutaneous lesions and high risk of developing non melanoma skin cancer. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidermodysplasia verruciformis
Follow this link to review classifications for Epidermodysplasia verruciformis in Orphanet.

Professional guidelines

PubMed

Boettler MA, Cartron AM, Shearer SM, Chung C, Trinidad J
Cutis 2023 Feb;111(2):E13-E15. doi: 10.12788/cutis.0726. PMID: 37075182
Zhu P, Qi RQ, Yang Y, Huo W, Zhang Y, He L, Wang G, Xu J, Zhang F, Yang R, Tu P, Ma L, Liu Q, Li Y, Gu H, Cheng B, Chen X, Chen A, Xiao S, Jin H, Zhang J, Li S, Yao Z, Pan W, Yang H, Shen Z, Cheng H, Song P, Fu L, Chen H, Geng S, Zeng K, Wang J, Tao J, Chen Y, Wang X, Gao XH
J Evid Based Med 2022 Sep;15(3):284-301. Epub 2022 Sep 18 doi: 10.1111/jebm.12494. PMID: 36117295Free PMC Article
Moore S, Rady P, Tyring S
Int J Dermatol 2022 Nov;61(11):1325-1335. Epub 2021 Aug 17 doi: 10.1111/ijd.15857. PMID: 34403500

Suggested Reading

Recent clinical studies

Therapy

Moore S, Rady P, Tyring S
Int J Dermatol 2022 Nov;61(11):1325-1335. Epub 2021 Aug 17 doi: 10.1111/ijd.15857. PMID: 34403500
Smola S
Adv Exp Med Biol 2020;1268:195-209. doi: 10.1007/978-3-030-46227-7_10. PMID: 32918220
Huang S, Wu JH, Lewis DJ, Rady PL, Tyring SK
Int J Dermatol 2018 Nov;57(11):1344-1350. Epub 2018 Aug 29 doi: 10.1111/ijd.14196. PMID: 30156265
Weiss RA
Br J Hosp Med (Lond) 2016 Oct;77(10):565-568. doi: 10.12968/hmed.2016.77.10.565. PMID: 27723397
Gewirtzman A, Bartlett B, Tyring S
Curr Opin Infect Dis 2008 Apr;21(2):141-6. doi: 10.1097/QCO.0b013e3282f486c9. PMID: 18317036

Prognosis

Cuestas D, Gómez A, Neri Morales C, Motta A, Rolon M, Suarez S, Polo R
Arch Dermatol Res 2024 Jul 13;316(7):471. doi: 10.1007/s00403-024-03016-x. PMID: 39001899Free PMC Article
Kinariwalla N, Coromilas AJ, Garzon MC, Levin LE, Magro C, Lauren CT
Pediatr Dermatol 2021 Nov;38(6):1541-1545. Epub 2021 Oct 20 doi: 10.1111/pde.14701. PMID: 34669978
Béziat V
Hum Genet 2020 Jun;139(6-7):919-939. Epub 2020 May 20 doi: 10.1007/s00439-020-02183-x. PMID: 32435828Free PMC Article
Connolly K, Manders P, Earls P, Epstein RJ
Cancer Treat Rev 2014 Mar;40(2):205-14. Epub 2013 Aug 22 doi: 10.1016/j.ctrv.2013.08.005. PMID: 24051018
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257

Clinical prediction guides

Dhiman A, Kansal NK, Baishya P
Skinmed 2024;22(4):301-304. Epub 2024 Sep 17 PMID: 39285575
Zhou J, Qian M, Jiang N, Wu J, Feng X, Yu M, Min Q, Xu H, Yang Y, Yang Q, Zhou F, Shao L, Zhu H, Yang Y, Wang JY, Ruan Q, Zhang W
J Clin Immunol 2024 May 22;44(6):131. doi: 10.1007/s10875-024-01735-4. PMID: 38775840
Majewski S, Jabłońska S
Arch Dermatol 1995 Nov;131(11):1312-8. PMID: 7503577
Galloway DA, McDougall JK
Adv Virus Res 1989;37:125-71. doi: 10.1016/s0065-3527(08)60834-9. PMID: 2557758
Orth G, Jablonska S, Breitburd F, Favre M, Croissant O
Bull Cancer 1978;65(2):151-64. PMID: 212142

Recent systematic reviews

Cuestas D, Gómez A, Neri Morales C, Motta A, Rolon M, Suarez S, Polo R
Arch Dermatol Res 2024 Jul 13;316(7):471. doi: 10.1007/s00403-024-03016-x. PMID: 39001899Free PMC Article
Biglari S, Moghaddam AS, Tabatabaiefar MA, Sherkat R, Youssefian L, Saeidian AH, Vahidnezhad F, Tsoi LC, Gudjonsson JE, Hakonarson H, Casanova JL, Béziat V, Jouanguy E, Vahidnezhad H
Genet Med 2024 Feb;26(2):101028. Epub 2023 Nov 14 doi: 10.1016/j.gim.2023.101028. PMID: 37978863Free PMC Article
Neagu N, Dianzani C, Venuti A, Bonin S, Voidăzan S, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2023 Jan;37(1):40-46. Epub 2022 Sep 1 doi: 10.1111/jdv.18548. PMID: 36000380
Ramezani M, Sadeghi M
Pol J Pathol 2017;68(4):330-342. doi: 10.5114/pjp.2017.73929. PMID: 29517204
Imahorn E, Yüksel Z, Spoerri I, Gürel G, Imhof C, Saraçoğlu ZN, Koku Aksu AE, Rady PL, Tyring SK, Kempf W, Itin PH, Burger B
J Eur Acad Dermatol Venereol 2017 Oct;31(10):1722-1726. Epub 2017 Aug 4 doi: 10.1111/jdv.14431. PMID: 28646613

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...