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Pseudomembranous Enterocolitis

MedGen UID:
8643
Concept ID:
C0014358
Disease or Syndrome
Synonym: Enterocolitis, Pseudomembranous

Definition

An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudomembranous Enterocolitis

Professional guidelines

PubMed

Guerri S, Danti G, Frezzetti G, Lucarelli E, Pradella S, Miele V
Radiol Med 2019 Dec;124(12):1185-1198. Epub 2019 Jul 13 doi: 10.1007/s11547-019-01066-0. PMID: 31302848
Lee YM, Huh KC, Yoon SM, Jang BI, Shin JE, Koo HS, Jung Y, Kim SH, Moon HS, Lee SW; Daejeon-Chungchung Intestinal Research Group
Gut Liver 2016 Mar;10(2):250-4. doi: 10.5009/gnl14435. PMID: 26260753Free PMC Article
Jaber MR, Olafsson S, Fung WL, Reeves ME
Am J Gastroenterol 2008 Dec;103(12):3195-203; quiz 3204. Epub 2008 Oct 1 doi: 10.1111/j.1572-0241.2008.02198.x. PMID: 18853982

Recent clinical studies

Etiology

Song JH, Kim YS
Gut Liver 2019 Jan 15;13(1):16-24. doi: 10.5009/gnl18071. PMID: 30400734Free PMC Article
Elliott B, Androga GO, Knight DR, Riley TV
Infect Genet Evol 2017 Apr;49:1-11. Epub 2016 Dec 22 doi: 10.1016/j.meegid.2016.12.018. PMID: 28012982
Farooq PD, Urrunaga NH, Tang DM, von Rosenvinge EC
Dis Mon 2015 May;61(5):181-206. Epub 2015 Mar 11 doi: 10.1016/j.disamonth.2015.01.006. PMID: 25769243Free PMC Article
Wang M, Johnson S
Cancer Treat Res 2014;161:237-51. doi: 10.1007/978-3-319-04220-6_8. PMID: 24706227
Coté GA, Buchman AL
Expert Opin Drug Saf 2006 May;5(3):361-72. doi: 10.1517/14740338.5.3.361. PMID: 16610966

Diagnosis

Gollol Raju NS, Jayananda S, Ali E, Harvin G
Am J Ther 2021 Jul-Aug 01;28(4):e492-e493. doi: 10.1097/MJT.0000000000001068. PMID: 34228655
Tang DM, Urrunaga NH, von Rosenvinge EC
Cleve Clin J Med 2016 May;83(5):361-6. doi: 10.3949/ccjm.83a.14183. PMID: 27168512
Curry S
Clin Lab Med 2010 Mar;30(1):329-42. doi: 10.1016/j.cll.2010.04.001. PMID: 20513554Free PMC Article
Coté GA, Buchman AL
Expert Opin Drug Saf 2006 May;5(3):361-72. doi: 10.1517/14740338.5.3.361. PMID: 16610966
Schroeder MS
Am Fam Physician 2005 Mar 1;71(5):921-8. PMID: 15768622

Therapy

Guery B, Menichetti F, Anttila VJ, Adomakoh N, Aguado JM, Bisnauthsing K, Georgopali A, Goldenberg SD, Karas A, Kazeem G, Longshaw C, Palacios-Fabrega JA, Cornely OA, Vehreschild MJGT; EXTEND Clinical Study Group
Lancet Infect Dis 2018 Mar;18(3):296-307. Epub 2017 Dec 19 doi: 10.1016/S1473-3099(17)30751-X. PMID: 29273269
Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, Johnston BC
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD006095. doi: 10.1002/14651858.CD006095.pub4. PMID: 29257353Free PMC Article
Noto MJ, Domenico HJ, Byrne DW, Talbot T, Rice TW, Bernard GR, Wheeler AP
JAMA 2015 Jan 27;313(4):369-78. doi: 10.1001/jama.2014.18400. PMID: 25602496Free PMC Article
Cornely OA, Crook DW, Esposito R, Poirier A, Somero MS, Weiss K, Sears P, Gorbach S; OPT-80-004 Clinical Study Group
Lancet Infect Dis 2012 Apr;12(4):281-9. Epub 2012 Feb 8 doi: 10.1016/S1473-3099(11)70374-7. PMID: 22321770
Louie TJ, Miller MA, Mullane KM, Weiss K, Lentnek A, Golan Y, Gorbach S, Sears P, Shue YK; OPT-80-003 Clinical Study Group
N Engl J Med 2011 Feb 3;364(5):422-31. doi: 10.1056/NEJMoa0910812. PMID: 21288078

Prognosis

Kodadek LM, Lipsett PA
Adv Surg 2018 Sep;52(1):29-42. Epub 2018 Jun 19 doi: 10.1016/j.yasu.2018.04.001. PMID: 30098619
Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, Johnston BC
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD006095. doi: 10.1002/14651858.CD006095.pub4. PMID: 29257353Free PMC Article
McFarland LV, Ozen M, Dinleyici EC, Goh S
World J Gastroenterol 2016 Mar 21;22(11):3078-104. doi: 10.3748/wjg.v22.i11.3078. PMID: 27003987Free PMC Article
Honda H, Dubberke ER
Curr Opin Gastroenterol 2014 Jan;30(1):54-62. doi: 10.1097/MOG.0000000000000018. PMID: 24285002
St-Vil D, LeBouthillier G, Luks FI, Bensoussan AL, Blanchard H, Youssef S
J Pediatr Surg 1992 Oct;27(10):1340-2. doi: 10.1016/0022-3468(92)90292-f. PMID: 1403517

Clinical prediction guides

Song EM, Choi A, Kim S, Jung SH
J Korean Med Sci 2023 Dec 4;38(47):e359. doi: 10.3346/jkms.2023.38.e359. PMID: 38050911Free PMC Article
Petersen C, Round JL
Cell Microbiol 2014 Jul;16(7):1024-33. Epub 2014 Jun 2 doi: 10.1111/cmi.12308. PMID: 24798552Free PMC Article
Smits LP, Bouter KE, de Vos WM, Borody TJ, Nieuwdorp M
Gastroenterology 2013 Nov;145(5):946-53. Epub 2013 Sep 7 doi: 10.1053/j.gastro.2013.08.058. PMID: 24018052
Hull MW, Beck PL
Can Fam Physician 2004 Nov;50:1536-40, 1543-5. PMID: 15597970Free PMC Article
DeWitt TG
Pediatr Rev 1989 Jul;11(1):6-13. doi: 10.1542/pir.11-1-6. PMID: 2664748

Recent systematic reviews

Sébastien P, Jacques D, Catherine P, Xavier G
BMC Infect Dis 2023 Oct 2;23(1):642. doi: 10.1186/s12879-023-08618-w. PMID: 37784031Free PMC Article
Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, Johnston BC
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD006095. doi: 10.1002/14651858.CD006095.pub4. PMID: 29257353Free PMC Article
Nelson RL, Suda KJ, Evans CT
Cochrane Database Syst Rev 2017 Mar 3;3(3):CD004610. doi: 10.1002/14651858.CD004610.pub5. PMID: 28257555Free PMC Article
McFarland LV, Ozen M, Dinleyici EC, Goh S
World J Gastroenterol 2016 Mar 21;22(11):3078-104. doi: 10.3748/wjg.v22.i11.3078. PMID: 27003987Free PMC Article
Bagdasarian N, Rao K, Malani PN
JAMA 2015 Jan 27;313(4):398-408. doi: 10.1001/jama.2014.17103. PMID: 25626036Free PMC Article

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