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Endocardial cushion defect(ECD)

MedGen UID:
41778
Concept ID:
C0014116
Congenital Abnormality
Synonyms: Cushion Defect, Endocardial; Cushion Defects, Endocardial; Defect, Endocardial Cushion; Defects, Endocardial Cushion; Endocardial Cushion Defect; Endocardial Cushion Defects
SNOMED CT: Endocardial cushion defect (15459006)
 
OMIM®: 606215

Definition

A spectrum of septal defects involving the ATRIAL SEPTUM; VENTRICULAR SEPTUM; and the atrioventricular valves (TRICUSPID VALVE; BICUSPID VALVE). These defects are due to incomplete growth and fusion of the ENDOCARDIAL CUSHIONS which are important in the formation of two atrioventricular canals, site of future atrioventricular valves. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndocardial cushion defect

Professional guidelines

PubMed

Li H, Zhang L, Cao X
J Pak Med Assoc 2020 Sep;70 [Special Issue](9):139-144. PMID: 33177743
Guo B, Xiao J, Li L, Wang S, Wang L, Liu S
Mol Med Rep 2018 May;17(5):7346-7350. Epub 2018 Mar 14 doi: 10.3892/mmr.2018.8742. PMID: 29568912
Chen CP, Chen CY, Chern SR, Su JW, Wang W
Taiwan J Obstet Gynecol 2012 Dec;51(4):643-8. doi: 10.1016/j.tjog.2012.10.001. PMID: 23276573

Recent clinical studies

Etiology

Wu MH, Chiu SN, Tseng WC, Lu CW, Kao FY, Huang SK
Heart Rhythm 2023 Sep;20(9):1248-1254. Epub 2023 May 9 doi: 10.1016/j.hrthm.2023.05.009. PMID: 37169157
Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M
J Card Surg 2022 Oct;37(10):3151-3158. Epub 2022 Jul 5 doi: 10.1111/jocs.16742. PMID: 35788993
Harvey DC, Baer RJ, Bandoli G, Chambers CD, Jelliffe-Pawlowski LL, Kumar SR
J Am Heart Assoc 2022 Jan 18;11(2):e022175. Epub 2022 Jan 11 doi: 10.1161/JAHA.121.022175. PMID: 35014860Free PMC Article
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Int J Cardiol 2016 Jan 1;202:784-95. Epub 2015 Sep 26 doi: 10.1016/j.ijcard.2015.09.081. PMID: 26476030
Zhao CM, Peng LY, Li L, Liu XY, Wang J, Zhang XL, Yuan F, Li RG, Qiu XB, Yang YQ
PLoS One 2015;10(4):e0124409. Epub 2015 Apr 20 doi: 10.1371/journal.pone.0124409. PMID: 25893250Free PMC Article

Diagnosis

Krasivskyi I, Ivanov B, Djordjevic I, Gaisendrees C, Gerfer S, Eghbalzadeh K, Kuhn E, Wahlers T, Mader N
Heart Lung Circ 2023 Mar;32(3):e12-e13. Epub 2022 Nov 29 doi: 10.1016/j.hlc.2022.10.016. PMID: 36460553
Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M
J Card Surg 2022 Oct;37(10):3151-3158. Epub 2022 Jul 5 doi: 10.1111/jocs.16742. PMID: 35788993
Harvey DC, Baer RJ, Bandoli G, Chambers CD, Jelliffe-Pawlowski LL, Kumar SR
J Am Heart Assoc 2022 Jan 18;11(2):e022175. Epub 2022 Jan 11 doi: 10.1161/JAHA.121.022175. PMID: 35014860Free PMC Article
Han J, Xiang H, Ridley WE, Ridley LJ
J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:31. doi: 10.1111/1754-9485.18_12785. PMID: 30309193
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Int J Cardiol 2016 Jan 1;202:784-95. Epub 2015 Sep 26 doi: 10.1016/j.ijcard.2015.09.081. PMID: 26476030

Therapy

Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M
J Card Surg 2022 Oct;37(10):3151-3158. Epub 2022 Jul 5 doi: 10.1111/jocs.16742. PMID: 35788993
Wu MH, Wang JK, Chiu SN, Lu CW, Lin MT, Chen CA, Tseng WC
Heart Rhythm 2022 Nov;19(11):1856-1863. Epub 2022 Jun 30 doi: 10.1016/j.hrthm.2022.06.032. PMID: 35781043
Huang CC, Chen BY, Pan SC, Ho YL, Guo YL
Sci Total Environ 2019 Mar 10;655:880-886. Epub 2018 Nov 20 doi: 10.1016/j.scitotenv.2018.11.284. PMID: 30481714
Ginde S, Lam J, Hill GD, Cohen S, Woods RK, Mitchell ME, Tweddell JS, Earing MG
J Thorac Cardiovasc Surg 2015 Aug;150(2):369-74. Epub 2015 May 7 doi: 10.1016/j.jtcvs.2015.05.011. PMID: 26048271
Yau WP, Mitchell AA, Lin KJ, Werler MM, Hernández-Díaz S
Am J Epidemiol 2013 Jul 15;178(2):198-208. Epub 2013 Jul 3 doi: 10.1093/aje/kws427. PMID: 23825167Free PMC Article

Prognosis

Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M
J Card Surg 2022 Oct;37(10):3151-3158. Epub 2022 Jul 5 doi: 10.1111/jocs.16742. PMID: 35788993
Wu MH, Wang JK, Chiu SN, Lu CW, Lin MT, Chen CA, Tseng WC
Heart Rhythm 2022 Nov;19(11):1856-1863. Epub 2022 Jun 30 doi: 10.1016/j.hrthm.2022.06.032. PMID: 35781043
Sainathan S, Agala CB, Said SM, Mulinari L, Sharma MS
J Card Surg 2022 Jun;37(6):1567-1573. Epub 2022 Mar 24 doi: 10.1111/jocs.16424. PMID: 35324033
Asim A, Agarwal S, Panigrahi I, Sarangi AN, Muthuswamy S, Kapoor A
Gene 2018 Jan 30;641:180-185. Epub 2017 Oct 18 doi: 10.1016/j.gene.2017.10.044. PMID: 29054759
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Int J Cardiol 2016 Jan 1;202:784-95. Epub 2015 Sep 26 doi: 10.1016/j.ijcard.2015.09.081. PMID: 26476030

Clinical prediction guides

Sainathan S, Said SM, Agala CB, Mullinari L, Sharma M
J Card Surg 2022 Oct;37(10):3151-3158. Epub 2022 Jul 5 doi: 10.1111/jocs.16742. PMID: 35788993
Wu MH, Wang JK, Chiu SN, Lu CW, Lin MT, Chen CA, Tseng WC
Heart Rhythm 2022 Nov;19(11):1856-1863. Epub 2022 Jun 30 doi: 10.1016/j.hrthm.2022.06.032. PMID: 35781043
Sainathan S, Agala CB, Said SM, Mulinari L, Sharma MS
J Card Surg 2022 Jun;37(6):1567-1573. Epub 2022 Mar 24 doi: 10.1111/jocs.16424. PMID: 35324033
Huang CC, Chen BY, Pan SC, Ho YL, Guo YL
Sci Total Environ 2019 Mar 10;655:880-886. Epub 2018 Nov 20 doi: 10.1016/j.scitotenv.2018.11.284. PMID: 30481714
Asim A, Agarwal S, Panigrahi I, Sarangi AN, Muthuswamy S, Kapoor A
Gene 2018 Jan 30;641:180-185. Epub 2017 Oct 18 doi: 10.1016/j.gene.2017.10.044. PMID: 29054759

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