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Tick-borne encephalitis

MedGen UID:
4034
•Concept ID:
C0014061
•
Disease or Syndrome
Synonyms: Encephalitis, Tick Borne; Encephalitis, Tick-Borne; Tick Borne Encephalitis; Tick-Borne Encephalitis
SNOMED CT: Viral encephalitis transmitted by tick (415821008); Tick-borne encephalitis (414093008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017572
Orphanet: ORPHA297

Definition

Tick-borne encephalitis is caused by an arbovirus of the Flaviviridae family (tick-borne encephalitis virus, TBEV), transmitted principally by the bite of the <i>Ixodes ricinus</i> tick. The symptomology is biphasic, with the initial phase being associated with a flu-like illness and the second phase (occurring in less than 10% of patients) with symptoms of meningitis or, more rarely, meningoencephalitis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTick-borne encephalitis
Follow this link to review classifications for Tick-borne encephalitis in Orphanet.

Professional guidelines

PubMed

New Approaches to the Prevention and Treatment of Viral Diseases.
Pronin AV, Narovlyansky AN, Sanin AV
Arch Immunol Ther Exp (Warsz) 2021 Apr 3;69(1):10. doi: 10.1007/s00005-021-00613-w. PMID: 33811524Free PMC Article
EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis.
Taba P, Schmutzhard E, Forsberg P, Lutsar I, Ljøstad U, Mygland Å, Levchenko I, Strle F, Steiner I
Eur J Neurol 2017 Oct;24(10):1214-e61. Epub 2017 Aug 1 doi: 10.1111/ene.13356. PMID: 28762591
Diagnosis and management of acute encephalitis.
Halperin JJ
Handb Clin Neurol 2017;140:337-347. doi: 10.1016/B978-0-444-63600-3.00018-0. PMID: 28187808

Recent clinical studies

Etiology

First evidence of tick-borne encephalitis (TBE) outside of Hokkaido Island in Japan.
Ohira M, Yoshii K, Aso Y, Nakajima H, Yamashita T, Takahashi-Iwata I, Maeda N, Shindo K, Suenaga T, Matsuura T, Sugie K, Hamano T, Arai A, Furutani R, Suzuki Y, Kaneko C, Kobayashi Y, Campos-Alberto E, Harper LR, Edwards J, Bender C, Pilz A, Ito S, Angulo FJ, Erber W, Madhava H, Moïsi J, Jodar L, Mizusawa H, Takao M
Emerg Microbes Infect 2023 Dec;12(2):2278898. Epub 2023 Nov 14 doi: 10.1080/22221751.2023.2278898. PMID: 37906509Free PMC Article
Tick-borne encephalitis in children.
Marvik Å, Ravn LM, Randby H, Stamnes Köpp UM, Revhaug C
Tidsskr Nor Laegeforen 2023 Oct 10;143(14) Epub 2023 Sep 21 doi: 10.4045/tidsskr.23.0222. PMID: 37830974
Tick-borne encephalitis.
Kaiser R
Infect Dis Clin North Am 2008 Sep;22(3):561-75, x. doi: 10.1016/j.idc.2008.03.013. PMID: 18755391
Tick-borne encephalitis.
Gritsun TS, Lashkevich VA, Gould EA
Antiviral Res 2003 Jan;57(1-2):129-46. doi: 10.1016/s0166-3542(02)00206-1. PMID: 12615309
Tick-borne encephalitis.
Dumpis U, Crook D, Oksi J
Clin Infect Dis 1999 Apr;28(4):882-90. doi: 10.1086/515195. PMID: 10825054

Diagnosis

Tick-borne encephalitis.
Wood C
Br J Nurs 2019 Nov 28;28(21):1356. doi: 10.12968/bjon.2019.28.21.1356. PMID: 31778339
Epidemiology and pathological mechanisms of tick-borne encephalitis.
Yoshii K
J Vet Med Sci 2019 Mar 14;81(3):343-347. Epub 2019 Jan 23 doi: 10.1292/jvms.18-0373. PMID: 30674746Free PMC Article
Tick-borne encephalitis.
Valarcher JF, Hägglund S, Juremalm M, Blomqvist G, Renström L, Zohari S, Leijon M, Chirico J
Rev Sci Tech 2015 Aug;34(2):453-66. doi: 10.20506/rst.34.2.2371. PMID: 26601448
Tick-borne encephalitis.
Lindquist L
Handb Clin Neurol 2014;123:531-59. doi: 10.1016/B978-0-444-53488-0.00025-0. PMID: 25015503
Tick-borne encephalitis.
Lindquist L, Vapalahti O
Lancet 2008 May 31;371(9627):1861-71. doi: 10.1016/S0140-6736(08)60800-4. PMID: 18514730

Therapy

Vaccines for Older Travelers.
Jilg W
Interdiscip Top Gerontol Geriatr 2020;43:158-181. Epub 2020 Apr 9 doi: 10.1159/000504492. PMID: 32305985
Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines.
Ruzek D, Avšič Županc T, Borde J, Chrdle A, Eyer L, Karganova G, Kholodilov I, Knap N, Kozlovskaya L, Matveev A, Miller AD, Osolodkin DI, Överby AK, Tikunova N, Tkachev S, Zajkowska J
Antiviral Res 2019 Apr;164:23-51. Epub 2019 Jan 31 doi: 10.1016/j.antiviral.2019.01.014. PMID: 30710567
Tick-borne encephalitis in China: A review of epidemiology and vaccines.
Xing Y, Schmitt HJ, Arguedas A, Yang J
Vaccine 2017 Mar 1;35(9):1227-1237. Epub 2017 Jan 30 doi: 10.1016/j.vaccine.2017.01.015. PMID: 28153343
TICK-BORNE ENCEPHALITIS VIRUS INFECTION IN HUMANS.
Hrnjaković Cvjetković I, Cvjetković D, Patić A, Radovanov J, Kovacević G, Milosević V
Med Pregl 2016 Mar-Apr;69(3-4):93-8. doi: 10.2298/mpns1604093h. PMID: 27506096
Tick-borne encephalitis.
Gritsun TS, Lashkevich VA, Gould EA
Antiviral Res 2003 Jan;57(1-2):129-46. doi: 10.1016/s0166-3542(02)00206-1. PMID: 12615309

Prognosis

Tick-borne encephalitis in children.
Marvik Å, Ravn LM, Randby H, Stamnes Köpp UM, Revhaug C
Tidsskr Nor Laegeforen 2023 Oct 10;143(14) Epub 2023 Sep 21 doi: 10.4045/tidsskr.23.0222. PMID: 37830974
Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture.
Chiffi G, Grandgirard D, Leib SL, Chrdle A, Růžek D
Rev Med Virol 2023 Sep;33(5):e2470. Epub 2023 Jul 1 doi: 10.1002/rmv.2470. PMID: 37392370
Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines.
Ruzek D, Avšič Županc T, Borde J, Chrdle A, Eyer L, Karganova G, Kholodilov I, Knap N, Kozlovskaya L, Matveev A, Miller AD, Osolodkin DI, Överby AK, Tikunova N, Tkachev S, Zajkowska J
Antiviral Res 2019 Apr;164:23-51. Epub 2019 Jan 31 doi: 10.1016/j.antiviral.2019.01.014. PMID: 30710567
Tick-borne encephalitis.
Kaiser R
Infect Dis Clin North Am 2008 Sep;22(3):561-75, x. doi: 10.1016/j.idc.2008.03.013. PMID: 18755391
Tick-borne encephalitis: rounding out the picture.
Heinz FX
Euro Surveill 2008 Apr 24;13(17) PMID: 18445450

Clinical prediction guides

Tick-borne encephalitis in pregnancy.
Kepková Marie
Ceska Gynekol 2023;88(2):106-109. doi: 10.48095/cccg2023106. PMID: 37130735
Tick-borne encephalitis in pediatrics: An often overlooked diagnosis.
Parfut A, Laugel E, Baer S, Gonzalez G, Hansmann Y, Wendling MJ, Fafi-Kremer S, Velay A
Infect Dis Now 2023 Mar;53(2):104645. Epub 2023 Jan 13 doi: 10.1016/j.idnow.2023.01.005. PMID: 36642097
Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines.
Ruzek D, Avšič Županc T, Borde J, Chrdle A, Eyer L, Karganova G, Kholodilov I, Knap N, Kozlovskaya L, Matveev A, Miller AD, Osolodkin DI, Överby AK, Tikunova N, Tkachev S, Zajkowska J
Antiviral Res 2019 Apr;164:23-51. Epub 2019 Jan 31 doi: 10.1016/j.antiviral.2019.01.014. PMID: 30710567
Tick-borne flaviviruses.
Lasala PR, Holbrook M
Clin Lab Med 2010 Mar;30(1):221-35. doi: 10.1016/j.cll.2010.01.002. PMID: 20513549
Tick-borne flaviviruses.
Gritsun TS, Nuttall PA, Gould EA
Adv Virus Res 2003;61:317-71. doi: 10.1016/s0065-3527(03)61008-0. PMID: 14714436

Recent systematic reviews

A systematic literature review of the effectiveness of tick-borne encephalitis vaccines in Europe.
Angulo FJ, Zhang P, Halsby K, Kelly P, Pilz A, Madhava H, Moïsi JC, Jodar L
Vaccine 2023 Nov 13;41(47):6914-6921. Epub 2023 Oct 17 doi: 10.1016/j.vaccine.2023.10.014. PMID: 37858450
The long-term efficacy of tick-borne encephalitis vaccines available in Europe - a systematic review.
Miazga W, Wnuk K, Tatara T, Świtalski J, Matera A, Religioni U, Gujski M
BMC Infect Dis 2023 Sep 21;23(1):621. doi: 10.1186/s12879-023-08562-9. PMID: 37735357Free PMC Article
Systematic Review and Meta-analysis of Foodborne Tick-Borne Encephalitis, Europe, 1980-2021.
Elbaz M, Gadoth A, Shepshelovich D, Shasha D, Rudoler N, Paran Y
Emerg Infect Dis 2022 Oct;28(10):1945-54. doi: 10.3201/eid2810.220498. PMID: 36149234Free PMC Article
Immunogenicity and safety of the tick-borne encephalitis vaccination (2009-2019): A systematic review.
Rampa JE, Askling HH, Lang P, Zens KD, Gültekin N, Stanga Z, Schlagenhauf P
Travel Med Infect Dis 2020 Sep-Oct;37:101876. Epub 2020 Sep 12 doi: 10.1016/j.tmaid.2020.101876. PMID: 32931931
Vaccines for preventing tick-borne encephalitis.
Demicheli V, Debalini MG, Rivetti A
Cochrane Database Syst Rev 2009 Jan 21;2009(1):CD000977. doi: 10.1002/14651858.CD000977.pub2. PMID: 19160184Free PMC Article

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