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Acute disseminated encephalomyelitis

MedGen UID:
4033
•Concept ID:
C0014059
•
Disease or Syndrome
Synonyms: Acute Disseminated Encephalomyelitides; Acute Disseminated Encephalomyelitis; Disseminated Encephalomyelitis, Acute; Encephalomyelitis, Acute Disseminated
SNOMED CT: ADEM - Acute disseminated encephalomyelitis (83942000); Acute disseminated encephalomyelitis (83942000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019383
Orphanet: ORPHA83597

Definition

A demyelinating disorder of the central nervous system. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute disseminated encephalomyelitis

Professional guidelines

PubMed

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient.
Wang CX
Paediatr Drugs 2021 May;23(3):213-221. Epub 2021 Apr 8 doi: 10.1007/s40272-021-00441-7. PMID: 33830467Free PMC Article
Diagnosis and Management of Acute Encephalitis in Children.
Aneja S, Sharma S
Indian J Pediatr 2019 Jan;86(1):70-75. Epub 2018 Sep 19 doi: 10.1007/s12098-018-2775-0. PMID: 30232787

Recent clinical studies

Etiology

Evaluation, Treatment, and Outcomes of Viral and Autoimmune Encephalitis in Children.
Vova JA, Howarth RA
Pediatr Clin North Am 2023 Jun;70(3):429-444. Epub 2023 Mar 21 doi: 10.1016/j.pcl.2023.01.007. PMID: 37121635
Dengue, chikungunya and zika arbovirus infections in Caribbean children.
Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979Free PMC Article
Pediatric autoimmune encephalitis: Recognition and diagnosis.
de Bruijn MAAM, Bruijstens AL, Bastiaansen AEM, van Sonderen A, Schreurs MWJ, Sillevis Smitt PAE, Hintzen RQ, Neuteboom RF, Titulaer MJ; CHANCE Study Group
Neurol Neuroimmunol Neuroinflamm 2020 May;7(3) Epub 2020 Feb 11 doi: 10.1212/NXI.0000000000000682. PMID: 32047077Free PMC Article
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Inflammatory demyelinating diseases of the central nervous system.
Höftberger R, Lassmann H
Handb Clin Neurol 2017;145:263-283. doi: 10.1016/B978-0-12-802395-2.00019-5. PMID: 28987175Free PMC Article

Diagnosis

Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient.
Wang CX
Paediatr Drugs 2021 May;23(3):213-221. Epub 2021 Apr 8 doi: 10.1007/s40272-021-00441-7. PMID: 33830467Free PMC Article
Viral Encephalitis.
Venkatesan A, Murphy OC
Neurol Clin 2018 Nov;36(4):705-724. Epub 2018 Sep 20 doi: 10.1016/j.ncl.2018.07.001. PMID: 30366550
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome.
Pohl D, Alper G, Van Haren K, Kornberg AJ, Lucchinetti CF, Tenembaum S, Belman AL
Neurology 2016 Aug 30;87(9 Suppl 2):S38-45. doi: 10.1212/WNL.0000000000002825. PMID: 27572859
Acute Disseminated Encephalomyelitis.
J Clin Apher 2016 Jun;31(3):163-202. doi: 10.1002/jca.21474. PMID: 27322219

Therapy

Diagnosis and Management of Acute Encephalitis in Children.
Aneja S, Sharma S
Indian J Pediatr 2019 Jan;86(1):70-75. Epub 2018 Sep 19 doi: 10.1007/s12098-018-2775-0. PMID: 30232787
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.
Ramanathan S, Mohammad S, Tantsis E, Nguyen TK, Merheb V, Fung VSC, White OB, Broadley S, Lechner-Scott J, Vucic S, Henderson APD, Barnett MH, Reddel SW, Brilot F, Dale RC; Australasian and New Zealand MOG Study Group
J Neurol Neurosurg Psychiatry 2018 Feb;89(2):127-137. Epub 2017 Nov 15 doi: 10.1136/jnnp-2017-316880. PMID: 29142145Free PMC Article
Pulse steroid therapy.
Sinha A, Bagga A
Indian J Pediatr 2008 Oct;75(10):1057-66. Epub 2008 Nov 21 doi: 10.1007/s12098-008-0210-7. PMID: 19023530
Mycoplasma pneumoniae ecephalitis.
Bitnun A, Ford-Jones E, Blaser S, Richardson S
Semin Pediatr Infect Dis 2003 Apr;14(2):96-107. doi: 10.1053/spid.2003.127226. PMID: 12881797

Prognosis

Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes.
Lee WJ, Lee HS, Kim DY, Lee HS, Moon J, Park KI, Lee SK, Chu K, Lee ST
Brain 2022 Oct 21;145(10):3509-3521. doi: 10.1093/brain/awac166. PMID: 35512357
Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient.
Wang CX
Paediatr Drugs 2021 May;23(3):213-221. Epub 2021 Apr 8 doi: 10.1007/s40272-021-00441-7. PMID: 33830467Free PMC Article
Pediatric multiple sclerosis: a review.
Alroughani R, Boyko A
BMC Neurol 2018 Mar 9;18(1):27. doi: 10.1186/s12883-018-1026-3. PMID: 29523094Free PMC Article
Inflammatory demyelinating diseases of the central nervous system.
Höftberger R, Lassmann H
Handb Clin Neurol 2017;145:263-283. doi: 10.1016/B978-0-12-802395-2.00019-5. PMID: 28987175Free PMC Article
Mycoplasma pneumoniae ecephalitis.
Bitnun A, Ford-Jones E, Blaser S, Richardson S
Semin Pediatr Infect Dis 2003 Apr;14(2):96-107. doi: 10.1053/spid.2003.127226. PMID: 12881797

Clinical prediction guides

COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals.
Faksova K, Walsh D, Jiang Y, Griffin J, Phillips A, Gentile A, Kwong JC, Macartney K, Naus M, Grange Z, Escolano S, Sepulveda G, Shetty A, Pillsbury A, Sullivan C, Naveed Z, Janjua NZ, Giglio N, Perälä J, Nasreen S, Gidding H, Hovi P, Vo T, Cui F, Deng L, Cullen L, Artama M, Lu H, Clothier HJ, Batty K, Paynter J, Petousis-Harris H, Buttery J, Black S, Hviid A
Vaccine 2024 Apr 2;42(9):2200-2211. Epub 2024 Feb 12 doi: 10.1016/j.vaccine.2024.01.100. PMID: 38350768
Dengue, chikungunya and zika arbovirus infections in Caribbean children.
Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979Free PMC Article
Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes.
Lee WJ, Lee HS, Kim DY, Lee HS, Moon J, Park KI, Lee SK, Chu K, Lee ST
Brain 2022 Oct 21;145(10):3509-3521. doi: 10.1093/brain/awac166. PMID: 35512357

Recent systematic reviews

Acute disseminated encephalomyelitis (ADEM) following COVID-19 vaccination: A systematic review.
Nabizadeh F, Noori M, Rahmani S, Hosseini H
J Clin Neurosci 2023 May;111:57-70. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.008. PMID: 36963124Free PMC Article
SARS-CoV-2-associated acute disseminated encephalomyelitis: a systematic review of the literature.
Wang Y, Wang Y, Huo L, Li Q, Chen J, Wang H
J Neurol 2022 Mar;269(3):1071-1092. Epub 2021 Aug 30 doi: 10.1007/s00415-021-10771-8. PMID: 34459986Free PMC Article
Multiple Sclerosis-Minimizing Errors in Radiological Diagnosis.
Boski N, Gulati V, Raj R, Gulati P
Neurol India 2021 Nov-Dec;69(6):1539-1546. doi: 10.4103/0028-3886.333497. PMID: 34979638
The neurological complications of chikungunya virus: A systematic review.
Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T
Rev Med Virol 2018 May;28(3):e1978. Epub 2018 Apr 19 doi: 10.1002/rmv.1978. PMID: 29671914Free PMC Article
Long-Term Neuropsychological Outcomes of Childhood Onset Acute Disseminated Encephalomyelitis (ADEM): a Meta-Analysis.
Burton KLO, Williams TA, Catchpoole SE, Brunsdon RK
Neuropsychol Rev 2017 Jun;27(2):124-133. Epub 2017 Mar 31 doi: 10.1007/s11065-017-9343-7. PMID: 28364141

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