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Amniotic fluid embolism

MedGen UID:
8586
•Concept ID:
C0013927
•
Disease or Syndrome
Synonyms: Amniotic Fluid Embolism; Amniotic Fluid Embolisms; Embolism, Amniotic Fluid; Embolisms, Amniotic Fluid
SNOMED CT: Amniotic fluid embolism (17263003); Amniotic fluid embolus (860708004)
 
Monarch Initiative: MONDO:0850046
Orphanet: ORPHA617304

Definition

Acute hypotension or cardiac arrest, acute hypoxia or coagulopathy in the absence of any other potential explanation related to the presence of amniotic fluid or the fetal debris within the maternal vascular system during the antepartum or intrapartum period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmniotic fluid embolism

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine Special Statement: Checklist for initial management of amniotic fluid embolism.
Patient Safety and Quality Committee, Society for Maternal-Fetal Medicine. Electronic address: smfm@smfm.org, Combs CA, Montgomery DM, Toner LE, Dildy GA
Am J Obstet Gynecol 2021 Apr;224(4):B29-B32. Epub 2021 Jan 6 doi: 10.1016/j.ajog.2021.01.001. PMID: 33417901
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420
Amniotic fluid embolism: an interdisciplinary challenge: epidemiology, diagnosis and treatment.
Rath WH, Hoferr S, Sinicina I
Dtsch Arztebl Int 2014 Feb 21;111(8):126-32. doi: 10.3238/arztebl.2014.0126. PMID: 24622759Free PMC Article

Recent clinical studies

Etiology

Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion.
Hofer S, Blaha J, Collins PW, Ducloy-Bouthors AS, Guasch E, Labate F, Lança F, Nyfløt LT, Steiner K, Van de Velde M
Eur J Anaesthesiol 2023 Jan 1;40(1):29-38. Epub 2022 Sep 22 doi: 10.1097/EJA.0000000000001744. PMID: 36131564Free PMC Article
Association of Pregnancy Characteristics and Maternal Mortality With Amniotic Fluid Embolism.
Mazza GR, Youssefzadeh AC, Klar M, Kunze M, Matsuzaki S, Mandelbaum RS, Ouzounian JG, Matsuo K
JAMA Netw Open 2022 Nov 1;5(11):e2242842. doi: 10.1001/jamanetworkopen.2022.42842. PMID: 36399343Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Postdelivery Emergencies.
Wheaton N, Al-Abdullah A, Haertlein T
Emerg Med Clin North Am 2019 May;37(2):287-300. doi: 10.1016/j.emc.2019.01.014. PMID: 30940373

Diagnosis

Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion.
Hofer S, Blaha J, Collins PW, Ducloy-Bouthors AS, Guasch E, Labate F, Lança F, Nyfløt LT, Steiner K, Van de Velde M
Eur J Anaesthesiol 2023 Jan 1;40(1):29-38. Epub 2022 Sep 22 doi: 10.1097/EJA.0000000000001744. PMID: 36131564Free PMC Article
Post-abortion Complications: A Narrative Review for Emergency Clinicians.
Bridwell RE, Long B, Montrief T, Gottlieb M
West J Emerg Med 2022 Oct 23;23(6):919-925. doi: 10.5811/westjem.2022.8.57929. PMID: 36409940Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420

Therapy

Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion.
Hofer S, Blaha J, Collins PW, Ducloy-Bouthors AS, Guasch E, Labate F, Lança F, Nyfløt LT, Steiner K, Van de Velde M
Eur J Anaesthesiol 2023 Jan 1;40(1):29-38. Epub 2022 Sep 22 doi: 10.1097/EJA.0000000000001744. PMID: 36131564Free PMC Article
Post-abortion Complications: A Narrative Review for Emergency Clinicians.
Bridwell RE, Long B, Montrief T, Gottlieb M
West J Emerg Med 2022 Oct 23;23(6):919-925. doi: 10.5811/westjem.2022.8.57929. PMID: 36409940Free PMC Article
Adult respiratory distress syndrome.
Cutts S, Talboys R, Paspula C, Prempeh EM, Fanous R, Ail D
Ann R Coll Surg Engl 2017 Jan;99(1):12-16. Epub 2016 Aug 11 doi: 10.1308/rcsbull.2017.12. PMID: 27513791Free PMC Article
Amniotic fluid embolism: diagnosis and management.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Pacheco LD, Saade G, Hankins GD, Clark SL
Am J Obstet Gynecol 2016 Aug;215(2):B16-24. Epub 2016 Mar 14 doi: 10.1016/j.ajog.2016.03.012. PMID: 26987420
ARDS in pregnancy.
Duarte AG
Clin Obstet Gynecol 2014 Dec;57(4):862-70. doi: 10.1097/GRF.0000000000000067. PMID: 25314088

Prognosis

Association of Pregnancy Characteristics and Maternal Mortality With Amniotic Fluid Embolism.
Mazza GR, Youssefzadeh AC, Klar M, Kunze M, Matsuzaki S, Mandelbaum RS, Ouzounian JG, Matsuo K
JAMA Netw Open 2022 Nov 1;5(11):e2242842. doi: 10.1001/jamanetworkopen.2022.42842. PMID: 36399343Free PMC Article
Pulmonary Embolism and Amniotic Fluid Embolism.
Coggins AS, Gomez E, Sheffield JS
Obstet Gynecol Clin North Am 2022 Sep;49(3):439-460. doi: 10.1016/j.ogc.2022.02.015. PMID: 36122978
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Amniotic Fluid Embolism.
Sundin CS, Mazac LB
MCN Am J Matern Child Nurs 2017 Jan/Feb;42(1):29-35. doi: 10.1097/NMC.0000000000000292. PMID: 27755062
Amniotic fluid embolism.
Clark SL
Obstet Gynecol 2014 Feb;123(2 Pt 1):337-348. doi: 10.1097/AOG.0000000000000107. PMID: 24402585

Clinical prediction guides

Current concepts in the use of cell salvage in obstetrics.
Neef V, Meybohm P, Zacharowski K, Kranke P
Curr Opin Anaesthesiol 2024 Jun 1;37(3):213-218. Epub 2024 Mar 12 doi: 10.1097/ACO.0000000000001337. PMID: 38391030Free PMC Article
Echocardiography findings in amniotic fluid embolism: a systematic review of the literature.
Wiseman D, Simard C, Yang SS, Koolian M, Abenhaim HA, Lipes J
Can J Anaesth 2023 Jan;70(1):151-160. Epub 2022 Oct 28 doi: 10.1007/s12630-022-02343-9. PMID: 36307749
Amniotic fluid embolism rescued by venoarterial extracorporeal membrane oxygenation.
Aissi James S, Klein T, Lebreton G, Nizard J, Chommeloux J, Bréchot N, Pineton de Chambrun M, Hékimian G, Luyt CE, Levy B, Kimmoun A, Combes A, Schmidt M
Crit Care 2022 Apr 7;26(1):96. doi: 10.1186/s13054-022-03969-3. PMID: 35392980Free PMC Article
Cell Salvage in Obstetrics.
Goucher H, Wong CA, Patel SK, Toledo P
Anesth Analg 2015 Aug;121(2):465-8. doi: 10.1213/ANE.0000000000000786. PMID: 26197375
Not only a clinical nightmare: amniotic fluid embolism in court.
Busardo FP, Gulino M, Di Luca NM, Vergallo GM, Pacchiarotti A, Frati P
Curr Pharm Biotechnol 2014;14(14):1195-200. doi: 10.2174/1389201015666140430103312. PMID: 24804728

Recent systematic reviews

Use of cell salvage at the time of cesarean delivery: a meta-analysis of randomized controlled trials.
Iyer NS, Khanuja K, Roman A, Al-Kouatly HB
Am J Obstet Gynecol MFM 2024 Feb;6(2):101257. Epub 2023 Dec 16 doi: 10.1016/j.ajogmf.2023.101257. PMID: 38109996
Echocardiography findings in amniotic fluid embolism: a systematic review of the literature.
Wiseman D, Simard C, Yang SS, Koolian M, Abenhaim HA, Lipes J
Can J Anaesth 2023 Jan;70(1):151-160. Epub 2022 Oct 28 doi: 10.1007/s12630-022-02343-9. PMID: 36307749
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Amniotic fluid embolism: what level of scientific evidence can be drawn? A systematic review.
Frati P, Foldes-Papp Z, Zaami S, Busardo FP
Curr Pharm Biotechnol 2014;14(14):1157-62. doi: 10.2174/1389201015666140430101639. PMID: 24804729
Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations.
Knight M, Berg C, Brocklehurst P, Kramer M, Lewis G, Oats J, Roberts CL, Spong C, Sullivan E, van Roosmalen J, Zwart J
BMC Pregnancy Childbirth 2012 Feb 10;12:7. doi: 10.1186/1471-2393-12-7. PMID: 22325370Free PMC Article

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