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cyclothymic disorder

MedGen UID:
1198
•Concept ID:
C0010598
•
Mental or Behavioral Dysfunction
Synonyms: Cyclothymia; Cyclothymic Disorder; Cyclothymic Disorders; Cyclothymic Personalities; Cyclothymic Personality; Disorder, Cyclothymic; Personality, Cyclothymic
SNOMED CT: Cyclothymia (76105009); Cyclothymic disorder (76105009); Affective personality trait (386798001); Cycloid personality (386798001); Unstable personality trait (386798001); Tends to be unstable in affect (386798001); Cyclothymic personality (386798001); Affective personality disorder (76105009)
 
Monarch Initiative: MONDO:0004572

Definition

A bipolar disorder in which an individual experiences recurring hypomanic and depressive symptoms whose severity or duration do not meet criteria as hypomanic or depressive episodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVcyclothymic disorder

Professional guidelines

PubMed

The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid substance use disorders.
Beaulieu S, Saury S, Sareen J, Tremblay J, Schütz CG, McIntyre RS, Schaffer A; Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force
Ann Clin Psychiatry 2012 Feb;24(1):38-55. PMID: 22303521
Treatment of cyclothymic disorder: commentary.
Baldessarini RJ, Vázquez G, Tondo L
Psychother Psychosom 2011;80(3):131-5. Epub 2011 Mar 3 doi: 10.1159/000322234. PMID: 21372620
Bipolar II disorder : epidemiology, diagnosis and management.
Benazzi F
CNS Drugs 2007;21(9):727-40. doi: 10.2165/00023210-200721090-00003. PMID: 17696573

Recent clinical studies

Etiology

Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.
Gillissie ES, Lui LMW, Ceban F, Miskowiak K, Gok S, Cao B, Teopiz KM, Ho R, Lee Y, Rosenblat JD, McIntyre RS
Bipolar Disord 2022 Mar;24(2):137-148. Epub 2021 Dec 8 doi: 10.1111/bdi.13163. PMID: 34825440
Cognitive deficits in bipolar disorders: Implications for emotion.
Lima IMM, Peckham AD, Johnson SL
Clin Psychol Rev 2018 Feb;59:126-136. Epub 2017 Nov 21 doi: 10.1016/j.cpr.2017.11.006. PMID: 29195773Free PMC Article
Longitudinal course and characteristics of cyclothymic disorder in youth.
Van Meter AR, Youngstrom EA, Birmaher B, Fristad MA, Horwitz SM, Frazier TW, Arnold LE, Findling RL
J Affect Disord 2017 Jun;215:314-322. Epub 2017 Mar 14 doi: 10.1016/j.jad.2017.03.019. PMID: 28365522Free PMC Article
Bipolar disorder diagnosis: challenges and future directions.
Phillips ML, Kupfer DJ
Lancet 2013 May 11;381(9878):1663-71. doi: 10.1016/S0140-6736(13)60989-7. PMID: 23663952Free PMC Article
Cyclothymic disorder: a critical review.
Van Meter AR, Youngstrom EA, Findling RL
Clin Psychol Rev 2012 Jun;32(4):229-43. Epub 2012 Feb 10 doi: 10.1016/j.cpr.2012.02.001. PMID: 22459786

Diagnosis

Cognitive deficits in bipolar disorders: Implications for emotion.
Lima IMM, Peckham AD, Johnson SL
Clin Psychol Rev 2018 Feb;59:126-136. Epub 2017 Nov 21 doi: 10.1016/j.cpr.2017.11.006. PMID: 29195773Free PMC Article
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament.
Perugi G, Hantouche E, Vannucchi G
Curr Neuropharmacol 2017 Apr;15(3):372-379. doi: 10.2174/1570159X14666160616120157. PMID: 28503108Free PMC Article
Bipolar disorder diagnosis: challenges and future directions.
Phillips ML, Kupfer DJ
Lancet 2013 May 11;381(9878):1663-71. doi: 10.1016/S0140-6736(13)60989-7. PMID: 23663952Free PMC Article
Cyclothymic disorder: a critical review.
Van Meter AR, Youngstrom EA, Findling RL
Clin Psychol Rev 2012 Jun;32(4):229-43. Epub 2012 Feb 10 doi: 10.1016/j.cpr.2012.02.001. PMID: 22459786
The evolving bipolar spectrum. Prototypes I, II, III, and IV.
Akiskal HS, Pinto O
Psychiatr Clin North Am 1999 Sep;22(3):517-34, vii. doi: 10.1016/s0193-953x(05)70093-9. PMID: 10550853

Therapy

Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.
Gillissie ES, Lui LMW, Ceban F, Miskowiak K, Gok S, Cao B, Teopiz KM, Ho R, Lee Y, Rosenblat JD, McIntyre RS
Bipolar Disord 2022 Mar;24(2):137-148. Epub 2021 Dec 8 doi: 10.1111/bdi.13163. PMID: 34825440
Longitudinal course and characteristics of cyclothymic disorder in youth.
Van Meter AR, Youngstrom EA, Birmaher B, Fristad MA, Horwitz SM, Frazier TW, Arnold LE, Findling RL
J Affect Disord 2017 Jun;215:314-322. Epub 2017 Mar 14 doi: 10.1016/j.jad.2017.03.019. PMID: 28365522Free PMC Article
Cyclothymia.
Parker G, McCraw S, Fletcher K
Depress Anxiety 2012 Jun;29(6):487-94. Epub 2012 May 2 doi: 10.1002/da.21950. PMID: 22553122
The evolving bipolar spectrum. Prototypes I, II, III, and IV.
Akiskal HS, Pinto O
Psychiatr Clin North Am 1999 Sep;22(3):517-34, vii. doi: 10.1016/s0193-953x(05)70093-9. PMID: 10550853
Dysthymic and cyclothymic depressions: therapeutic considerations.
Akiskal HS
J Clin Psychiatry 1994 Apr;55 Suppl:46-52. PMID: 8077176

Prognosis

Cognitive deficits in bipolar disorders: Implications for emotion.
Lima IMM, Peckham AD, Johnson SL
Clin Psychol Rev 2018 Feb;59:126-136. Epub 2017 Nov 21 doi: 10.1016/j.cpr.2017.11.006. PMID: 29195773Free PMC Article
Longitudinal course and characteristics of cyclothymic disorder in youth.
Van Meter AR, Youngstrom EA, Birmaher B, Fristad MA, Horwitz SM, Frazier TW, Arnold LE, Findling RL
J Affect Disord 2017 Jun;215:314-322. Epub 2017 Mar 14 doi: 10.1016/j.jad.2017.03.019. PMID: 28365522Free PMC Article
Bipolar disorder: clinical overview.
Müller JK, Leweke FM
Med Monatsschr Pharm 2016 Sep;39(9):363- 9. PMID: 29956510
Cyclothymic disorder: a critical review.
Van Meter AR, Youngstrom EA, Findling RL
Clin Psychol Rev 2012 Jun;32(4):229-43. Epub 2012 Feb 10 doi: 10.1016/j.cpr.2012.02.001. PMID: 22459786
Dysthymic and cyclothymic depressions: therapeutic considerations.
Akiskal HS
J Clin Psychiatry 1994 Apr;55 Suppl:46-52. PMID: 8077176

Clinical prediction guides

The assessment of cyclothymic-hypersensitive temperament in youth with mood disorders and attention deficit hyperactivity disorder.
Pisano S, Sesso G, Senese VP, Catone G, Milone A, Masi G
J Affect Disord 2022 Feb 1;298(Pt A):322-328. Epub 2021 Nov 9 doi: 10.1016/j.jad.2021.11.013. PMID: 34763030
Cognitive deficits in bipolar disorders: Implications for emotion.
Lima IMM, Peckham AD, Johnson SL
Clin Psychol Rev 2018 Feb;59:126-136. Epub 2017 Nov 21 doi: 10.1016/j.cpr.2017.11.006. PMID: 29195773Free PMC Article
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament.
Perugi G, Hantouche E, Vannucchi G
Curr Neuropharmacol 2017 Apr;15(3):372-379. doi: 10.2174/1570159X14666160616120157. PMID: 28503108Free PMC Article
Longitudinal course and characteristics of cyclothymic disorder in youth.
Van Meter AR, Youngstrom EA, Birmaher B, Fristad MA, Horwitz SM, Frazier TW, Arnold LE, Findling RL
J Affect Disord 2017 Jun;215:314-322. Epub 2017 Mar 14 doi: 10.1016/j.jad.2017.03.019. PMID: 28365522Free PMC Article
Leptin in bipolar disorder: A systematic review and meta-analysis.
Fernandes BS, Dash S, Jacka F, Dodd S, Carvalho AF, Köhler CA, Steiner J, da Graça Cantarelli M, Nardin P, Gonçalves CA, Berk M
Eur Psychiatry 2016 May;35:1-7. Epub 2016 Apr 8 doi: 10.1016/j.eurpsy.2016.02.003. PMID: 27065008

Recent systematic reviews

Childhood trauma and cognitive functioning in mood disorders: A systematic review.
Barczyk ZA, Foulds JA, Porter RJ, Douglas KM
Bipolar Disord 2023 Jun;25(4):263-277. Epub 2023 Mar 29 doi: 10.1111/bdi.13321. PMID: 36949602
Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.
Gillissie ES, Lui LMW, Ceban F, Miskowiak K, Gok S, Cao B, Teopiz KM, Ho R, Lee Y, Rosenblat JD, McIntyre RS
Bipolar Disord 2022 Mar;24(2):137-148. Epub 2021 Dec 8 doi: 10.1111/bdi.13163. PMID: 34825440
Chemokine alterations in bipolar disorder: A systematic review and meta-analysis.
Misiak B, Bartoli F, Carrà G, Małecka M, Samochowiec J, Jarosz K, Banik A, Stańczykiewicz B
Brain Behav Immun 2020 Aug;88:870-877. Epub 2020 Apr 9 doi: 10.1016/j.bbi.2020.04.013. PMID: 32278851
Leptin in bipolar disorder: A systematic review and meta-analysis.
Fernandes BS, Dash S, Jacka F, Dodd S, Carvalho AF, Köhler CA, Steiner J, da Graça Cantarelli M, Nardin P, Gonçalves CA, Berk M
Eur Psychiatry 2016 May;35:1-7. Epub 2016 Apr 8 doi: 10.1016/j.eurpsy.2016.02.003. PMID: 27065008
Screening for bipolar spectrum disorders: A comprehensive meta-analysis of accuracy studies.
Carvalho AF, Takwoingi Y, Sales PM, Soczynska JK, Köhler CA, Freitas TH, Quevedo J, Hyphantis TN, McIntyre RS, Vieta E
J Affect Disord 2015 Feb 1;172:337-46. Epub 2014 Oct 23 doi: 10.1016/j.jad.2014.10.024. PMID: 25451435

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