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Clonorchiasis

MedGen UID:
3119
•Concept ID:
C0009021
•
Disease or Syndrome
Synonyms: Clonorchiases; Clonorchis Infection; Clonorchis Infections; Clonorchis sinensis Infection; Clonorchis sinensis Infections; Infection, Clonorchis; Infection, Clonorchis sinensis; Infection, Opisthorchis sinensis; Opisthorchis sinensis Infection; Opisthorchis sinensis Infections
SNOMED CT: Clonorchiasis (11938002); Chinese liver fluke disease (11938002); Oriental liver fluke disease (11938002); Hepatic distomiasis due to Clonorchis sinensis (11938002); Clonorchiosis (11938002)
 
Monarch Initiative: MONDO:0005705

Definition

Infection of the biliary passages with clonorchis sinensis, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonorchiasis

Professional guidelines

PubMed

Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control.
Qian M-B, Keiser J, Utzinger J, Zhou X-N
Clin Microbiol Rev 2024 Mar 14;37(1):e0000923. Epub 2024 Jan 3 doi: 10.1128/cmr.00009-23. PMID: 38169283Free PMC Article
Cost yield of different treatment strategies against Clonorchis sinensis infection.
Qian MB, Zhou CH, Zhu HH, Chen YD, Zhou XN
Infect Dis Poverty 2021 Dec 22;10(1):136. doi: 10.1186/s40249-021-00917-1. PMID: 34933693Free PMC Article
Endoscopic diagnosis and management of tropical parasitic infestations.
Reddy DN, Sriram PV, Rao GV
Gastrointest Endosc Clin N Am 2003 Oct;13(4):765-73, x-xi. doi: 10.1016/s1052-5157(03)00072-2. PMID: 14986797

Recent clinical studies

Etiology

Liver Flukes: Clonorchis and Opisthorchis.
Saijuntha W, Sithithaworn P, Wangboon C, Andrews RH, Petney TN
Adv Exp Med Biol 2024;1454:239-284. doi: 10.1007/978-3-031-60121-7_7. PMID: 39008268
FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma.
Xu L, Zhang Y, Lin Z, Deng X, Ren X, Huang M, Li S, Zhou Q, Fang F, Yang Q, Zheng G, Chen Z, Wu Z, Sun X, Lin J, Shen J, Guo J, Li X, Xue T, Tan J, Lin X, Tan L, Peng H, Shen S, Peng S, Li S, Liang L, Cleary JM, Lai J, Xie Y, Kuang M
J Hepatol 2024 Aug;81(2):265-277. Epub 2024 Mar 19 doi: 10.1016/j.jhep.2024.03.016. PMID: 38508240
Introduction.
Khuntikeo N, Andrews RH, Petney TN, Khan SA
Recent Results Cancer Res 2023;219:1-5. doi: 10.1007/978-3-031-35166-2_1. PMID: 37660328
Liver Fluke-Associated Biliary Tract Cancer.
Prueksapanich P, Piyachaturawat P, Aumpansub P, Ridtitid W, Chaiteerakij R, Rerknimitr R
Gut Liver 2018 May 15;12(3):236-245. doi: 10.5009/gnl17102. PMID: 28783896Free PMC Article
Biological agents.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
IARC Monogr Eval Carcinog Risks Hum 2012;100(Pt B):1-441. PMID: 23189750Free PMC Article

Diagnosis

Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control.
Qian M-B, Keiser J, Utzinger J, Zhou X-N
Clin Microbiol Rev 2024 Mar 14;37(1):e0000923. Epub 2024 Jan 3 doi: 10.1128/cmr.00009-23. PMID: 38169283Free PMC Article
Clonorchis sinensis Liver Flukes.
Cai S, Kuang M
N Engl J Med 2023 Dec 28;389(26):e57. Epub 2023 Dec 23 doi: 10.1056/NEJMicm2304237. PMID: 38146747
Introduction.
Khuntikeo N, Andrews RH, Petney TN, Khan SA
Recent Results Cancer Res 2023;219:1-5. doi: 10.1007/978-3-031-35166-2_1. PMID: 37660328
Clonorchis sinensis and clonorchiasis.
Na BK, Pak JH, Hong SJ
Acta Trop 2020 Mar;203:105309. Epub 2019 Dec 17 doi: 10.1016/j.actatropica.2019.105309. PMID: 31862466
Clonorchiasis.
Qian MB, Utzinger J, Keiser J, Zhou XN
Lancet 2016 Feb 20;387(10020):800-10. Epub 2015 Aug 21 doi: 10.1016/S0140-6736(15)60313-0. PMID: 26299184

Therapy

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
The control of clonorchiasis in Guangdong province, southern China.
Deng ZH, Fang YY, Zhang QM, Mao Q, Pei FQ, Liu MR
Acta Trop 2020 Feb;202:105246. Epub 2019 Oct 28 doi: 10.1016/j.actatropica.2019.105246. PMID: 31672488
Current status of Clonorchis sinensis and clonorchiasis in China.
Lai DH, Hong XK, Su BX, Liang C, Hide G, Zhang X, Yu X, Lun ZR
Trans R Soc Trop Med Hyg 2016 Jan;110(1):21-7. doi: 10.1093/trstmh/trv100. PMID: 26740359
Clonorchiasis.
Qian MB, Utzinger J, Keiser J, Zhou XN
Lancet 2016 Feb 20;387(10020):800-10. Epub 2015 Aug 21 doi: 10.1016/S0140-6736(15)60313-0. PMID: 26299184
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601

Prognosis

FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma.
Xu L, Zhang Y, Lin Z, Deng X, Ren X, Huang M, Li S, Zhou Q, Fang F, Yang Q, Zheng G, Chen Z, Wu Z, Sun X, Lin J, Shen J, Guo J, Li X, Xue T, Tan J, Lin X, Tan L, Peng H, Shen S, Peng S, Li S, Liang L, Cleary JM, Lai J, Xie Y, Kuang M
J Hepatol 2024 Aug;81(2):265-277. Epub 2024 Mar 19 doi: 10.1016/j.jhep.2024.03.016. PMID: 38508240
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin.
Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B
Parasitol Int 2012 Mar;61(1):10-6. Epub 2011 Aug 25 doi: 10.1016/j.parint.2011.08.014. PMID: 21893213Free PMC Article
Liver flukes: the malady neglected.
Lim JH
Korean J Radiol 2011 May-Jun;12(3):269-79. Epub 2011 Apr 25 doi: 10.3348/kjr.2011.12.3.269. PMID: 21603286Free PMC Article
Biliary parasites.
Osman M, Lausten SB, El-Sefi T, Boghdadi I, Rashed MY, Jensen SL
Dig Surg 1998;15(4):287-96. doi: 10.1159/000018640. PMID: 9845601
Imaging of the biliary tract.
Goldberg HI
Curr Opin Radiol 1992 Jun;4(3):62-9. PMID: 1581135

Clinical prediction guides

Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis.
Lin Q, Tang Z, Qin Y, Deng X, Wei C, Liu F, Pan X, Liu D, Zhan T, Fang M
PLoS Negl Trop Dis 2024 Jan;18(1):e0011906. Epub 2024 Jan 29 doi: 10.1371/journal.pntd.0011906. PMID: 38285640Free PMC Article
ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells.
Bian M, Li S, Zhou H, Bi L, Shen Y, Tingjin C, Yu X, Huang Y, Xu Q
PLoS Negl Trop Dis 2023 Nov;17(11):e0011727. Epub 2023 Nov 10 doi: 10.1371/journal.pntd.0011727. PMID: 37948465Free PMC Article
Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis.
Qian MB, Patel C, Palmeirim MS, Wang X, Schindler C, Utzinger J, Zhou XN, Keiser J
Lancet Microbe 2022 Aug;3(8):e616-e624. Epub 2022 Jun 10 doi: 10.1016/S2666-5247(22)00026-X. PMID: 35697047
The control of clonorchiasis in Guangdong province, southern China.
Deng ZH, Fang YY, Zhang QM, Mao Q, Pei FQ, Liu MR
Acta Trop 2020 Feb;202:105246. Epub 2019 Oct 28 doi: 10.1016/j.actatropica.2019.105246. PMID: 31672488
Parasite Infection, Carcinogenesis and Human Malignancy.
van Tong H, Brindley PJ, Meyer CG, Velavan TP
EBioMedicine 2017 Feb;15:12-23. Epub 2016 Dec 2 doi: 10.1016/j.ebiom.2016.11.034. PMID: 27956028Free PMC Article

Recent systematic reviews

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis.
Sota P, Andityas M, Kotepui M, Sripa B
Infect Dis Poverty 2024 May 8;13(1):33. doi: 10.1186/s40249-024-01201-8. PMID: 38720371Free PMC Article
Spatio-temporal disparities of Clonorchis sinensis infection in animal hosts in China: a systematic review and meta-analysis.
Liu K, Tan J, Xiao L, Pan RT, Yao XY, Shi FY, Li SZ, Li LH
Infect Dis Poverty 2023 Oct 17;12(1):97. doi: 10.1186/s40249-023-01146-4. PMID: 37845775Free PMC Article
Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis.
Qian MB, Patel C, Palmeirim MS, Wang X, Schindler C, Utzinger J, Zhou XN, Keiser J
Lancet Microbe 2022 Aug;3(8):e616-e624. Epub 2022 Jun 10 doi: 10.1016/S2666-5247(22)00026-X. PMID: 35697047
Risk mapping of clonorchiasis in the People's Republic of China: A systematic review and Bayesian geostatistical analysis.
Lai YS, Zhou XN, Pan ZH, Utzinger J, Vounatsou P
PLoS Negl Trop Dis 2017 Mar;11(3):e0005239. Epub 2017 Mar 2 doi: 10.1371/journal.pntd.0005239. PMID: 28253272Free PMC Article
Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review.
Machicado C, Marcos LA
Int J Cancer 2016 Jun 15;138(12):2915-21. Epub 2016 Feb 19 doi: 10.1002/ijc.30028. PMID: 26840624

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