Dysplasia of cervix

MedGen UID:: 2971
•Concept ID:: C0007868
•: Disease or Syndrome

Synonyms:	Cervical Dysplasia; Cervical Dysplasia, Uterine; Cervical Dysplasias; Cervical Intraepithelial Neoplasia; Cervical Intraepithelial Neoplasm; Cervical Intraepithelial Neoplasms; Cervix Dysplasia; Cervix Uteri Dysplasia; Cervix Uteri Dysplasias; Dysplasia of Cervix Uteri; Dysplasia, Cervical; Dysplasia, Cervix; Dysplasia, Uterine Cervical; Intraepithelial Neoplasia, Cervical; Intraepithelial Neoplasm, Cervical; Intraepithelial Neoplasms, Cervical; Neoplasia, Cervical Intraepithelial; Neoplasm, Cervical Intraepithelial; Neoplasms, Cervical Intraepithelial; Uterine Cervical Dysplasia
SNOMED CT:	Dysplasia of cervix (73391008); Cervical dysplasia (73391008); Dysplasia of cervix uteri (73391008)

HPO:	HP:0032131
Monarch Initiative:	MONDO:0006736

Definition

Cervical dysplasia is the precursor to cervical cancer. It is caused by the persistent infection of the human papillomavirus (HPV) into the cervical tissue. Affected cells develop morphologic features with immature basaloid- type squamous cells and mitotic figures in the upper half of the cervical epithelium. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDysplasia of cervix

Abnormality of the genital system
- Abnormal reproductive system morphology
  - Abnormality of the female genitalia
    - Abnormal morphology of female internal genitalia
      - Congenital uterine anomaly
        Abnormal uterine cervix morphology
        Dysplasia of cervix
        Atypical Squamous Cells of the Cervix
        Squamous Intraepithelial Lesions of the Cervix

Professional guidelines

PubMed

European consensus statement on expert colposcopy.

McGee AE, Alibegashvili T, Elfgren K, Frey B, Grigore M, Heinonen A, Jach R, Jariene K, Kesic V, Küppers V, Kyrgiou M, Leeson S, Louwers J, Mazurec M, Mergui J, Pedro A, Šavrova A, Siegler E, Tabuica U, Trojnarska D, Trzeszcz M, Turyna R, Volodko N, Cruickshank ME; European Federation for Colposcopy and Pathology of the Lower Genital Tract (EFC) and the European Society of Gynaecological Oncology (ESGO)
Eur J Obstet Gynecol Reprod Biol 2023 Nov;290:27-37. Epub 2023 Aug 31 doi: 10.1016/j.ejogrb.2023.08.369. PMID: 37716200

Primary HPV screening for cervical cancer.

Bhatla N, Singhal S
Best Pract Res Clin Obstet Gynaecol 2020 May;65:98-108. Epub 2020 Mar 2 doi: 10.1016/j.bpobgyn.2020.02.008. PMID: 32291178

Cervical cancer: screening, diagnosis and staging.

Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

See all (1192)