U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tumorigenesis

MedGen UID:
3302
•Concept ID:
C0007621
•
Neoplastic Process
Synonyms: Cell Neoplastic Transformation; Cell Neoplastic Transformations; Cell Transformation, Neoplastic; Cell Transformations, Neoplastic; Neoplastic Cell Transformation; Neoplastic Cell Transformations; Neoplastic Transformation, Cell; Neoplastic Transformations, Cell; Transformation, Cell Neoplastic; Transformation, Neoplastic Cell; Transformation, Tumorigenic; Transformations, Cell Neoplastic; Transformations, Neoplastic Cell; Transformations, Tumorigenic; Tumorigenic Transformation; Tumorigenic Transformations

Definition

A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation. [from NCI]

Professional guidelines

PubMed

Biomarkers for the diagnosis and management of heart failure.
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Ketogenic diet in the treatment of cancer - Where do we stand?
Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B
Mol Metab 2020 Mar;33:102-121. Epub 2019 Jul 27 doi: 10.1016/j.molmet.2019.06.026. PMID: 31399389Free PMC Article
Epidrugs: targeting epigenetic marks in cancer treatment.
Miranda Furtado CL, Dos Santos Luciano MC, Silva Santos RD, Furtado GP, Moraes MO, Pessoa C
Epigenetics 2019 Dec;14(12):1164-1176. Epub 2019 Jul 13 doi: 10.1080/15592294.2019.1640546. PMID: 31282279Free PMC Article

Recent clinical studies

Etiology

FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms.
Azzam SK, Alsafar H, Sajini AA
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073800. PMID: 35409166Free PMC Article
Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis.
Cai J, Sun L, Gonzalez FJ
Cell Host Microbe 2022 Mar 9;30(3):289-300. doi: 10.1016/j.chom.2022.02.004. PMID: 35271802Free PMC Article
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Yang J, Wei H, Zhou Y, Szeto CH, Li C, Lin Y, Coker OO, Lau HCH, Chan AWH, Sung JJY, Yu J
Gastroenterology 2022 Jan;162(1):135-149.e2. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.041. PMID: 34461052
Dietary fat, bile acid metabolism and colorectal cancer.
Ocvirk S, O'Keefe SJD
Semin Cancer Biol 2021 Aug;73:347-355. Epub 2020 Oct 16 doi: 10.1016/j.semcancer.2020.10.003. PMID: 33069873
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.
Bhardwaj P, Au CC, Benito-Martin A, Ladumor H, Oshchepkova S, Moges R, Brown KA
J Steroid Biochem Mol Biol 2019 May;189:161-170. Epub 2019 Mar 6 doi: 10.1016/j.jsbmb.2019.03.002. PMID: 30851382Free PMC Article

Diagnosis

The exercise IL-6 enigma in cancer.
Orange ST, Leslie J, Ross M, Mann DA, Wackerhage H
Trends Endocrinol Metab 2023 Nov;34(11):749-763. Epub 2023 Aug 24 doi: 10.1016/j.tem.2023.08.001. PMID: 37633799
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
Qu R, Zhang Y, Ma Y, Zhou X, Sun L, Jiang C, Zhang Z, Fu W
Adv Sci (Weinh) 2023 Aug;10(23):e2205563. Epub 2023 Jun 1 doi: 10.1002/advs.202205563. PMID: 37263983Free PMC Article
Gut microbiota in colorectal cancer development and therapy.
Wong CC, Yu J
Nat Rev Clin Oncol 2023 Jul;20(7):429-452. Epub 2023 May 11 doi: 10.1038/s41571-023-00766-x. PMID: 37169888
Cancer-associated fibroblasts in colorectal cancer.
Kamali Zonouzi S, Pezeshki PS, Razi S, Rezaei N
Clin Transl Oncol 2022 May;24(5):757-769. Epub 2021 Nov 28 doi: 10.1007/s12094-021-02734-2. PMID: 34839457
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.
Sulli G, Lam MTY, Panda S
Trends Cancer 2019 Aug;5(8):475-494. Epub 2019 Aug 3 doi: 10.1016/j.trecan.2019.07.002. PMID: 31421905Free PMC Article

Therapy

CDK4 and CDK6 kinases: From basic science to cancer therapy.
Fassl A, Geng Y, Sicinski P
Science 2022 Jan 14;375(6577):eabc1495. doi: 10.1126/science.abc1495. PMID: 35025636Free PMC Article
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis.
Tamura R
Int J Mol Sci 2021 May 29;22(11) doi: 10.3390/ijms22115850. PMID: 34072574Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Epigenetic therapy for ovarian cancer: promise and progress.
Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB
Clin Epigenetics 2019 Jan 15;11(1):7. doi: 10.1186/s13148-018-0602-0. PMID: 30646939Free PMC Article
A highlight on Sonic hedgehog pathway.
Carballo GB, Honorato JR, de Lopes GPF, Spohr TCLSE
Cell Commun Signal 2018 Mar 20;16(1):11. doi: 10.1186/s12964-018-0220-7. PMID: 29558958Free PMC Article

Prognosis

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Obesity, sleep apnea, and cancer.
Almendros I, Martinez-Garcia MA, Farré R, Gozal D
Int J Obes (Lond) 2020 Aug;44(8):1653-1667. Epub 2020 Feb 18 doi: 10.1038/s41366-020-0549-z. PMID: 32071426
Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer.
Liu T, Zhang X, Du L, Wang Y, Liu X, Tian H, Wang L, Li P, Zhao Y, Duan W, Xie Y, Sun Z, Wang C
Mol Cancer 2019 Mar 19;18(1):43. doi: 10.1186/s12943-019-0981-7. PMID: 30890168Free PMC Article
Ovarian cancer statistics, 2018.
Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL
CA Cancer J Clin 2018 Jul;68(4):284-296. Epub 2018 May 29 doi: 10.3322/caac.21456. PMID: 29809280Free PMC Article
Silent corticotroph adenomas.
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907

Clinical prediction guides

Leveraging a cuproptosis-based signature to predict the prognosis and drug sensitivity of cutaneous melanoma.
Liu D, Yang F, Zhang T, Mao R
J Transl Med 2023 Jan 30;21(1):57. doi: 10.1186/s12967-023-03891-4. PMID: 36717900Free PMC Article
m6A-immune-related lncRNA prognostic signature for predicting immune landscape and prognosis of bladder cancer.
Feng ZH, Liang YP, Cen JJ, Yao HH, Lin HS, Li JY, Liang H, Wang Z, Deng Q, Cao JZ, Huang Y, Wei JH, Luo JH, Chen W, Chen ZH
J Transl Med 2022 Oct 29;20(1):492. doi: 10.1186/s12967-022-03711-1. PMID: 36309694Free PMC Article
Comprehensive assessment of cellular senescence in the tumor microenvironment.
Wang X, Ma L, Pei X, Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP, Chen HZ
Brief Bioinform 2022 May 13;23(3) doi: 10.1093/bib/bbac118. PMID: 35419596Free PMC Article
Biomarkers for the diagnosis and management of heart failure.
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article

Recent systematic reviews

Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review.
Terp SK, Stoico MP, Dybkær K, Pedersen IS
Clin Epigenetics 2023 Feb 14;15(1):24. doi: 10.1186/s13148-023-01440-w. PMID: 36788585Free PMC Article
The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review.
Bouleftour W, Guillot A, Magne N
Mol Cancer Ther 2022 Apr 1;21(4):493-501. doi: 10.1158/1535-7163.MCT-21-0846. PMID: 35131876
Alternative splicing and cancer: a systematic review.
Zhang Y, Qian J, Gu C, Yang Y
Signal Transduct Target Ther 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. PMID: 33623018Free PMC Article
Selective autophagy of intracellular organelles: recent research advances.
Li W, He P, Huang Y, Li YF, Lu J, Li M, Kurihara H, Luo Z, Meng T, Onishi M, Ma C, Jiang L, Hu Y, Gong Q, Zhu D, Xu Y, Liu R, Liu L, Yi C, Zhu Y, Ma N, Okamoto K, Xie Z, Liu J, He RR, Feng D
Theranostics 2021;11(1):222-256. Epub 2021 Jan 1 doi: 10.7150/thno.49860. PMID: 33391472Free PMC Article
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
Braidy N, Liu Y
Exp Gerontol 2020 Apr;132:110831. Epub 2020 Jan 7 doi: 10.1016/j.exger.2020.110831. PMID: 31917996

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...