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Carcinoid heart disease

MedGen UID:
762
•Concept ID:
C0007093
•
Disease or Syndrome
Synonyms: Carcinoid Heart Disease; Carcinoid Heart Diseases; Heart Disease, Carcinoid; Heart Diseases, Carcinoid
SNOMED CT: Carcinoid heart disease (36222008)
 
Monarch Initiative: MONDO:0043529

Definition

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid heart disease

Professional guidelines

PubMed

Management of carcinoid heart disease.
Hack M, Bhamidipati CM
Curr Probl Cancer 2024 Oct;52:101128. Epub 2024 Aug 21 doi: 10.1016/j.currproblcancer.2024.101128. PMID: 39173543
Carcinoid Heart Disease Management: A Multi-Disciplinary Collaboration.
Das S, Stockton SS, Hassan SA
Oncologist 2023 Jul 5;28(7):575-583. doi: 10.1093/oncolo/oyad126. PMID: 37209415Free PMC Article
Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143

Recent clinical studies

Etiology

Carcinoid heart disease in patients with midgut neuroendocrine tumours.
Delhomme C, Walter T, Arangalage D, Suc G, Hentic O, Cachier A, Alkhoder S, François L, Lombard-Bohas C, Iung B, Ruszniewski P, de Mestier L
J Neuroendocrinol 2023 Apr;35(4):e13262. Epub 2023 Apr 2 doi: 10.1111/jne.13262. PMID: 37005217
Interventional Strategies in Cancer-induced Cardiovascular Disease.
Pushparaji B, Donisan T, Balanescu DV, Palaskas N, Kim P, Lopez-Mattei J, Cilingiroglu M, Hassan SA, Boudoulas KD, Marmagkiolis K, Hajjar LA, Iliescu CA
Curr Oncol Rep 2021 Sep 27;23(11):133. doi: 10.1007/s11912-021-01113-y. PMID: 34570291
Serotonin levels and 1-year mortality in patients with neuroendocrine tumors: a systematic review and meta-analysis.
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
"Eyeing" the Cause of Heart Failure: Visible Telltale Clues.
Fred HL, Thangam M
Tex Heart Inst J 2016 Dec;43(6):472-557. Epub 2016 Dec 1 doi: 10.14503/THIJ-16-6085. PMID: 28154499Free PMC Article
A rare case of a carcinoid myocardial mass.
Forcillo J, Mansour AM, Jeanmart H
Can J Cardiol 2015 May;31(5):691.e5-7. Epub 2014 Nov 26 doi: 10.1016/j.cjca.2014.11.018. PMID: 25818529

Diagnosis

Carcinoid syndrome-Symptoms and therapeutic approaches.
Chrisoulidou A
Hell J Nucl Med 2023 May-Aug;26 Suppl:52-56. PMID: 37658565
New murmur.
Hayes D, Morgan H, Brown N
Heart 2020 Dec;106(24):1926-1952. doi: 10.1136/heartjnl-2020-317521. PMID: 33243785
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Carcinoid tumors.
Sippel RS, Chen H
Surg Oncol Clin N Am 2006 Jul;15(3):463-78. doi: 10.1016/j.soc.2006.05.002. PMID: 16882492
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article

Therapy

203 Pb-VMT-α-NET Scintigraphy of a Patient With Neuroendocrine Tumor.
Müller D, Herrmann H, Schultz MK, Solbach C, Ettrich T, Prasad V
Clin Nucl Med 2023 Jan 1;48(1):54-55. Epub 2022 Oct 18 doi: 10.1097/RLU.0000000000004464. PMID: 36257061Free PMC Article
Interventional Strategies in Cancer-induced Cardiovascular Disease.
Pushparaji B, Donisan T, Balanescu DV, Palaskas N, Kim P, Lopez-Mattei J, Cilingiroglu M, Hassan SA, Boudoulas KD, Marmagkiolis K, Hajjar LA, Iliescu CA
Curr Oncol Rep 2021 Sep 27;23(11):133. doi: 10.1007/s11912-021-01113-y. PMID: 34570291
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Cardiac effects of noncardiac neoplasms.
Schoen FJ, Berger BM, Guerina NG
Cardiol Clin 1984 Nov;2(4):657-70. PMID: 6400009

Prognosis

Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Carcinoid tumors.
Sippel RS, Chen H
Surg Oncol Clin N Am 2006 Jul;15(3):463-78. doi: 10.1016/j.soc.2006.05.002. PMID: 16882492
Carcinoid tumors.
Kulke MH, Mayer RJ
N Engl J Med 1999 Mar 18;340(11):858-68. doi: 10.1056/NEJM199903183401107. PMID: 10080850
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article

Clinical prediction guides

Cardiac Imaging in Carcinoid Heart Disease.
Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA
JACC Cardiovasc Imaging 2021 Nov;14(11):2240-2253. Epub 2021 Apr 14 doi: 10.1016/j.jcmg.2020.12.030. PMID: 33865761
Pulmonary valve in carcinoid disease: be suspicious of functional assessment.
Gamarra AL, Cecconi A, Rojas-Gonzalez A, Olivera MJ, Monguio E, Jimenez-Borreguero LJ, Alfonso F
Int J Cardiovasc Imaging 2021 Feb;37(2):707-709. Epub 2020 Sep 4 doi: 10.1007/s10554-020-01983-6. PMID: 32886227
Serotonin levels and 1-year mortality in patients with neuroendocrine tumors: a systematic review and meta-analysis.
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
"Eyeing" the Cause of Heart Failure: Visible Telltale Clues.
Fred HL, Thangam M
Tex Heart Inst J 2016 Dec;43(6):472-557. Epub 2016 Dec 1 doi: 10.14503/THIJ-16-6085. PMID: 28154499Free PMC Article
Carcinoid heart disease.
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

Outcomes of surgical treatment for carcinoid heart disease: A systematic review and meta-analysis.
O'Malley TJ, Jimenez DC, Saxena A, Weber MP, Samuels LE, Entwistle JW, Guy TS, Massey HT, Morris RJ, Tchantchaleishvili V
Surgery 2021 Aug;170(2):390-396. Epub 2021 Mar 31 doi: 10.1016/j.surg.2021.02.054. PMID: 33812754
Carcinoid Heart Disease: Prognostic Value of 5-Hydroxyindoleacetic Acid Levels and Impact on Survival: A Systematic Literature Review.
Buchanan-Hughes A, Pashley A, Feuilly M, Marteau F, Pritchard DM, Singh S
Neuroendocrinology 2021;111(1-2):1-15. Epub 2020 Feb 25 doi: 10.1159/000506744. PMID: 32097914
Serotonin levels and 1-year mortality in patients with neuroendocrine tumors: a systematic review and meta-analysis.
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Mega-dose intravenous octreotide for the treatment of carcinoid crisis: a systematic review.
Seymour N, Sawh SC
Can J Anaesth 2013 May;60(5):492-9. Epub 2013 Jan 18 doi: 10.1007/s12630-012-9879-1. PMID: 23328959

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