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Mucocutaneous candidiasis

MedGen UID:
2804
•Concept ID:
C0006848
•
Disease or Syndrome
Synonyms: Candida infection of skin and mucous membranes; Mucocutaneous Candidiasis
SNOMED CT: Candida infection of skin and mucous membranes (29147005); Mucocutaneous candidiasis (29147005)

Definition

A fungal infection of the skin, nails, oral and vaginal mucosal sites caused by species of the genus Candida. It manifests with white discoloration of the tongue and swelling, redness, and tenderness of the nails. [from NCI]

Professional guidelines

PubMed

Progress in molecular diagnosis and treatment of chronic mucocutaneous candidiasis.
Jing D, Liang G, Li X, Liu W
Front Immunol 2024;15:1343138. Epub 2024 Jan 24 doi: 10.3389/fimmu.2024.1343138. PMID: 38327523Free PMC Article
JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study.
Fischer M, Olbrich P, Hadjadj J, Aumann V, Bakhtiar S, Barlogis V, von Bismarck P, Bloomfield M, Booth C, Buddingh EP, Cagdas D, Castelle M, Chan AY, Chandrakasan S, Chetty K, Cougoul P, Crickx E, Dara J, Deyà-Martínez A, Farmand S, Formankova R, Gennery AR, Gonzalez-Granado LI, Hagin D, Hanitsch LG, Hanzlikovà J, Hauck F, Ivorra-Cortés J, Kisand K, Kiykim A, Körholz J, Leahy TR, van Montfrans J, Nademi Z, Nelken B, Parikh S, Plado S, Ramakers J, Redlich A, Rieux-Laucat F, Rivière JG, Rodina Y, Júnior PR, Salou S, Schuetz C, Shcherbina A, Slatter MA, Touzot F, Unal E, Lankester AC, Burns S, Seppänen MRJ, Neth O, Albert MH, Ehl S, Neven B, Speckmann C
J Allergy Clin Immunol 2024 Jan;153(1):275-286.e18. Epub 2023 Nov 5 doi: 10.1016/j.jaci.2023.10.018. PMID: 37935260
Treatment options for chronic mucocutaneous candidiasis.
van de Veerdonk FL, Netea MG
J Infect 2016 Jul 5;72 Suppl:S56-60. Epub 2016 May 6 doi: 10.1016/j.jinf.2016.04.023. PMID: 27161991

Recent clinical studies

Etiology

Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Chronic Candidiasis in Children.
Green L, Dolen WK
Curr Allergy Asthma Rep 2017 May;17(5):31. doi: 10.1007/s11882-017-0699-9. PMID: 28429308
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A; International STAT1 Gain-of-Function Study Group
Blood 2016 Jun 23;127(25):3154-64. Epub 2016 Apr 25 doi: 10.1182/blood-2015-11-679902. PMID: 27114460Free PMC Article
Mucocutaneous candidiasis.
Rowen JL
Semin Perinatol 2003 Oct;27(5):406-13. doi: 10.1016/s0146-0005(03)00066-1. PMID: 14626505
Mucosal candidiasis.
Vazquez JA, Sobel JD
Infect Dis Clin North Am 2002 Dec;16(4):793-820, v. doi: 10.1016/s0891-5520(02)00042-9. PMID: 12512182

Diagnosis

Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy.
Okada S, Asano T, Moriya K, Boisson-Dupuis S, Kobayashi M, Casanova JL, Puel A
J Clin Immunol 2020 Nov;40(8):1065-1081. Epub 2020 Aug 27 doi: 10.1007/s10875-020-00847-x. PMID: 32852681Free PMC Article
Chronic Candidiasis in Children.
Green L, Dolen WK
Curr Allergy Asthma Rep 2017 May;17(5):31. doi: 10.1007/s11882-017-0699-9. PMID: 28429308
Oral candidiasis.
Millsop JW, Fazel N
Clin Dermatol 2016 Jul-Aug;34(4):487-94. Epub 2016 Mar 2 doi: 10.1016/j.clindermatol.2016.02.022. PMID: 27343964
Anticytokine autoantibody-associated immunodeficiency.
Browne SK
Annu Rev Immunol 2014;32:635-57. Epub 2014 Feb 5 doi: 10.1146/annurev-immunol-032713-120222. PMID: 24499273

Therapy

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Oral candidiasis.
Millsop JW, Fazel N
Clin Dermatol 2016 Jul-Aug;34(4):487-94. Epub 2016 Mar 2 doi: 10.1016/j.clindermatol.2016.02.022. PMID: 27343964
IL-17 and infections.
Ling Y, Puel A
Actas Dermosifiliogr 2014 Oct;105 Suppl 1:34-40. doi: 10.1016/S0001-7310(14)70016-X. PMID: 25398490
Chronic mucocutaneous candidiasis.
Kirkpatrick CH
Pediatr Infect Dis J 2001 Feb;20(2):197-206. doi: 10.1097/00006454-200102000-00017. PMID: 11224843
Cimetidine: an immunomodulator.
Kumar A
DICP 1990 Mar;24(3):289-95. doi: 10.1177/106002809002400316. PMID: 2138376

Prognosis

A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1.
Oftedal BE, Berger AH, Bruserud Ø, Goldfarb Y, Sulen A, Breivik L, Hellesen A, Ben-Dor S, Haffner-Krausz R, Knappskog PM, Johansson S, Wolff AS, Bratland E, Abramson J, Husebye ES
J Clin Invest 2023 Nov 1;133(21) doi: 10.1172/JCI169704. PMID: 37909333Free PMC Article
Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy.
Okada S, Asano T, Moriya K, Boisson-Dupuis S, Kobayashi M, Casanova JL, Puel A
J Clin Immunol 2020 Nov;40(8):1065-1081. Epub 2020 Aug 27 doi: 10.1007/s10875-020-00847-x. PMID: 32852681Free PMC Article
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A; International STAT1 Gain-of-Function Study Group
Blood 2016 Jun 23;127(25):3154-64. Epub 2016 Apr 25 doi: 10.1182/blood-2015-11-679902. PMID: 27114460Free PMC Article
Autoimmune hepatitis.
Obermayer-Straub P, Strassburg CP, Manns MP
J Hepatol 2000;32(1 Suppl):181-97. doi: 10.1016/s0168-8278(00)80425-0. PMID: 10728804

Clinical prediction guides

Human autoantibodies underlying infectious diseases.
Puel A, Bastard P, Bustamante J, Casanova JL
J Exp Med 2022 Apr 4;219(4) Epub 2022 Mar 23 doi: 10.1084/jem.20211387. PMID: 35319722Free PMC Article
Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Chronic Candidiasis in Children.
Green L, Dolen WK
Curr Allergy Asthma Rep 2017 May;17(5):31. doi: 10.1007/s11882-017-0699-9. PMID: 28429308
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A; International STAT1 Gain-of-Function Study Group
Blood 2016 Jun 23;127(25):3154-64. Epub 2016 Apr 25 doi: 10.1182/blood-2015-11-679902. PMID: 27114460Free PMC Article
IL-17 and infections.
Ling Y, Puel A
Actas Dermosifiliogr 2014 Oct;105 Suppl 1:34-40. doi: 10.1016/S0001-7310(14)70016-X. PMID: 25398490

Recent systematic reviews

Prevalence, antifungal susceptibility and etiology of vulvovaginal candidiasis in sub-Saharan Africa: a systematic review with meta-analysis and meta-regression.
Mushi MF, Olum R, Bongomin F
Med Mycol 2022 Jul 9;60(7) doi: 10.1093/mmy/myac037. PMID: 35781514
Clinical, immunological, and genetic features in 938 patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a systematic review.
Sharifinejad N, Zaki-Dizaji M, Tebyanian S, Zainaldain H, Jamee M, Rizvi FS, Hosseinzadeh S, Fayyaz F, Hamedifar H, Sabzevari A, Matloubi M, Heropolitańska-Pliszka E, Aghamahdi F, Abolhassani H, Azizi G
Expert Rev Clin Immunol 2021 Aug;17(8):807-817. Epub 2021 Jun 3 doi: 10.1080/1744666X.2021.1925543. PMID: 33957837
Clinical Relevance of Gain- and Loss-of-Function Germline Mutations in STAT1: A Systematic Review.
Zhang W, Chen X, Gao G, Xing S, Zhou L, Tang X, Zhao X, An Y
Front Immunol 2021;12:654406. Epub 2021 Mar 11 doi: 10.3389/fimmu.2021.654406. PMID: 33777053Free PMC Article
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
Austin N, Darlow BA, McGuire W
Cochrane Database Syst Rev 2009 Oct 7;(4):CD003478. doi: 10.1002/14651858.CD003478.pub3. PMID: 19821309
Prophylactic oral antifungal agents to prevent systemic candida infection in preterm infants.
Austin NC, Darlow B
Cochrane Database Syst Rev 2004;(1):CD003478. doi: 10.1002/14651858.CD003478.pub2. PMID: 14974017

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