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Burning mouth syndrome

MedGen UID:
14254
•Concept ID:
C0006430
•
Disease or Syndrome
Synonyms: Burning Mouth Syndrome; Burning Mouth Syndromes; Mouth Syndrome, Burning; Mouth Syndromes, Burning; Syndrome, Burning Mouth; Syndromes, Burning Mouth
SNOMED CT: Burning mouth syndrome (399165002); Orodynia (399165002); Stomatopyrosis (399165002); BMS - burning mouth syndrome (399165002)
 
Monarch Initiative: MONDO:0006687
Orphanet: ORPHA353253

Definition

A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBurning mouth syndrome

Professional guidelines

PubMed

Hyposalivation and Xerostomia and Burning Mouth Syndrome: Medical Management.
Thakkar JP, Lane CJ
Oral Maxillofac Surg Clin North Am 2022 Feb;34(1):135-146. Epub 2021 Sep 29 doi: 10.1016/j.coms.2021.08.002. PMID: 34598858
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Differential diagnosis of facial pain and guidelines for management.
Zakrzewska JM
Br J Anaesth 2013 Jul;111(1):95-104. doi: 10.1093/bja/aet125. PMID: 23794651

Recent clinical studies

Etiology

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
Burning Mouth Syndrome Etiology: A Narrative Review.
Russo M, Crafa P, Guglielmetti S, Franzoni L, Fiore W, Di Mario F
J Gastrointestin Liver Dis 2022 Jun 12;31(2):223-228. doi: 10.15403/jgld-4245. PMID: 35574619
Burning mouth syndrome.
Jääskeläinen SK, Woda A
Cephalalgia 2017 Jun;37(7):627-647. Epub 2017 Mar 15 doi: 10.1177/0333102417694883. PMID: 28569120
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Burning mouth syndrome.
Crow HC, Gonzalez Y
Oral Maxillofac Surg Clin North Am 2013 Feb;25(1):67-76, vi. Epub 2012 Nov 30 doi: 10.1016/j.coms.2012.11.001. PMID: 23201368

Diagnosis

Burning Mouth Syndrome.
Khawaja SN, Alaswaiti OF, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):49-60. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.004. PMID: 36404080
Burning mouth syndrome: a review of therapeutic approach.
Nosratzehi T
J Complement Integr Med 2021 Dec 9;19(1):83-90. doi: 10.1515/jcim-2021-0434. PMID: 34881535
Burning Mouth Syndrome.
Klein B, Thoppay JR, De Rossi SS, Ciarrocca K
Dermatol Clin 2020 Oct;38(4):477-483. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.008. PMID: 32892856
Burning Mouth Syndrome.
Bender SD
Dent Clin North Am 2018 Oct;62(4):585-596. Epub 2018 Jul 27 doi: 10.1016/j.cden.2018.05.006. PMID: 30189984
Burning mouth syndrome: a review and update.
Silvestre FJ, Silvestre-Rangil J, López-Jornet P
Rev Neurol 2015 May 16;60(10):457-63. PMID: 25952601

Therapy

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Burning mouth syndrome: a review of therapeutic approach.
Nosratzehi T
J Complement Integr Med 2021 Dec 9;19(1):83-90. doi: 10.1515/jcim-2021-0434. PMID: 34881535
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
Burning mouth syndrome: a review and update.
Silvestre FJ, Silvestre-Rangil J, López-Jornet P
Rev Neurol 2015 May 16;60(10):457-63. PMID: 25952601

Prognosis

Effects of low-level laser therapy on burning pain and quality of life in patients with burning mouth syndrome: a systematic review and meta-analysis.
Lu C, Yang C, Li X, Du G, Zhou X, Luo W, Du Q, Tang G
BMC Oral Health 2023 Oct 9;23(1):734. doi: 10.1186/s12903-023-03441-w. PMID: 37814265Free PMC Article
Long-term prognosis of burning mouth syndrome following treatment.
Kim MJ, Choi JH, Kho HS
Int J Oral Maxillofac Surg 2022 Dec;51(12):1538-1544. Epub 2022 Aug 20 doi: 10.1016/j.ijom.2022.08.011. PMID: 35999146
Burning mouth syndrome: a review on diagnosis and treatment.
Coculescu EC, Radu A, Coculescu BI
J Med Life 2014 Oct-Dec;7(4):512-5. PMID: 25713611Free PMC Article
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Burning mouth syndrome.
Nasri-Heir C
Alpha Omegan 2012 Winter;105(3-4):76-81. PMID: 23589947

Clinical prediction guides

Small Fiber Neuropathy in Burning Mouth Syndrome: A Systematic Review.
Kouri M, Adamo D, Vardas E, Georgaki M, Canfora F, Mignogna MD, Nikitakis N
Int J Mol Sci 2024 Oct 24;25(21) doi: 10.3390/ijms252111442. PMID: 39518993Free PMC Article
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Burning mouth syndrome-a diagnostic dilemma.
Ni Riordain R, O'Dwyer S, McCreary C
Ir J Med Sci 2019 Aug;188(3):731-734. Epub 2019 Jan 2 doi: 10.1007/s11845-018-01960-y. PMID: 30603879
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Burning mouth syndrome.
Buchanan JA, Zakrzewska JM
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418666Free PMC Article

Recent systematic reviews

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.
Reyad AA, Mishriky R, Girgis E
Dent Med Probl 2020 Jul-Sep;57(3):295-304. doi: 10.17219/dmp/120991. PMID: 33113291
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
Burning mouth syndrome.
Zakrzewska J, Buchanan JA
BMJ Clin Evid 2016 Jan 7;2016 PMID: 26745781Free PMC Article

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