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Blood group incompatibility

MedGen UID:
609
•Concept ID:
C0005806
•
Pathologic Function
Synonyms: Blood Group Incompatibilities; Blood Group Incompatibility; Blood Type Incompatibilities; Blood Type Incompatibility; Incompatibilities, Blood Group; Incompatibility, Blood Group; Incompatibility, Blood Type
 
Monarch Initiative: MONDO:0002901

Definition

An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient''s serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlood group incompatibility

Professional guidelines

PubMed

Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.
Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M
World J Pediatr 2020 Oct;16(5):480-493. Epub 2020 Feb 12 doi: 10.1007/s12519-020-00339-3. PMID: 32052364
Diagnostic laboratory technologies for the fetus and neonate with isoimmunization.
Geaghan SM
Semin Perinatol 2011 Jun;35(3):148-54. doi: 10.1053/j.semperi.2011.02.009. PMID: 21641488
Non-invasive prenatal diagnosis and determination of fetal Rh status.
van der Schoot CE, Hahn S, Chitty LS
Semin Fetal Neonatal Med 2008 Apr;13(2):63-8. Epub 2008 Feb 4 doi: 10.1016/j.siny.2007.12.012. PMID: 18249590

Recent clinical studies

Etiology

Hemolytic Transfusion Reactions.
Panch SR, Montemayor-Garcia C, Klein HG
N Engl J Med 2019 Jul 11;381(2):150-162. doi: 10.1056/NEJMra1802338. PMID: 31291517
ABO blood group incompatibility and infertility: still an open debate.
Galliano D
Fertil Steril 2017 Mar;107(3):579. Epub 2017 Jan 16 doi: 10.1016/j.fertnstert.2016.12.010. PMID: 28104243
Hemolysis from ABO Incompatibility.
Simmons DP, Savage WJ
Hematol Oncol Clin North Am 2015 Jun;29(3):429-43. Epub 2015 Mar 10 doi: 10.1016/j.hoc.2015.01.003. PMID: 26043383
Blood product transfusions and reactions.
Osterman JL, Arora S
Emerg Med Clin North Am 2014 Aug;32(3):727-38. Epub 2014 Jun 12 doi: 10.1016/j.emc.2014.04.012. PMID: 25060259
IMMUNE HEMOLYSIS.
SWISHER SN
Annu Rev Med 1964;15:1-22. doi: 10.1146/annurev.me.15.020164.000245. PMID: 14133844

Diagnosis

ABO hemolytic disease of the newborn: a need for clarity and consistency in diagnosis.
Watchko JF
J Perinatol 2023 Feb;43(2):242-247. Epub 2022 Nov 8 doi: 10.1038/s41372-022-01556-6. PMID: 36344813
Hemolytic Transfusion Reactions.
Panch SR, Montemayor-Garcia C, Klein HG
N Engl J Med 2019 Jul 11;381(2):150-162. doi: 10.1056/NEJMra1802338. PMID: 31291517
Noninfectious transfusion-associated adverse events and their mitigation strategies.
Goel R, Tobian AAR, Shaz BH
Blood 2019 Apr 25;133(17):1831-1839. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-833988. PMID: 30808635
ABO blood group incompatibility and infertility: still an open debate.
Galliano D
Fertil Steril 2017 Mar;107(3):579. Epub 2017 Jan 16 doi: 10.1016/j.fertnstert.2016.12.010. PMID: 28104243
The direct antiglobulin test: a critical step in the evaluation of hemolysis.
Zantek ND, Koepsell SA, Tharp DR Jr, Cohn CS
Am J Hematol 2012 Jul;87(7):707-9. Epub 2012 May 6 doi: 10.1002/ajh.23218. PMID: 22566278

Therapy

Noninfectious transfusion-associated adverse events and their mitigation strategies.
Goel R, Tobian AAR, Shaz BH
Blood 2019 Apr 25;133(17):1831-1839. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-833988. PMID: 30808635
ABO blood group incompatibility and infertility: still an open debate.
Galliano D
Fertil Steril 2017 Mar;107(3):579. Epub 2017 Jan 16 doi: 10.1016/j.fertnstert.2016.12.010. PMID: 28104243
Mechanisms of sickle cell alloimmunization.
Yazdanbakhsh K
Transfus Clin Biol 2015 Aug;22(3):178-81. Epub 2015 Jun 6 doi: 10.1016/j.tracli.2015.05.005. PMID: 26056038Free PMC Article
Hemolysis from ABO Incompatibility.
Simmons DP, Savage WJ
Hematol Oncol Clin North Am 2015 Jun;29(3):429-43. Epub 2015 Mar 10 doi: 10.1016/j.hoc.2015.01.003. PMID: 26043383
Blood product transfusions and reactions.
Osterman JL, Arora S
Emerg Med Clin North Am 2014 Aug;32(3):727-38. Epub 2014 Jun 12 doi: 10.1016/j.emc.2014.04.012. PMID: 25060259

Prognosis

Creating Options for Difficult-to-match Kidney Transplant Candidates.
de Klerk M, Kal-van Gestel JA, van de Wetering J, Kho ML, Middel-de Sterke S, Betjes MGH, Zuidema WC, Roelen D, Glorie K, Roodnat JI
Transplantation 2021 Jan 1;105(1):240-248. doi: 10.1097/TP.0000000000003203. PMID: 32101984
ABO incompatible platelets: risks versus benefit.
Dunbar NM, Ornstein DL, Dumont LJ
Curr Opin Hematol 2012 Nov;19(6):475-9. doi: 10.1097/MOH.0b013e328358b135. PMID: 22914587
Living donor kidney transplantation.
Fehrman-Ekholm I
Transplant Proc 2006 Oct;38(8):2637-41. doi: 10.1016/j.transproceed.2006.07.027. PMID: 17098024
Neonatal jaundice in Asia.
Ho NK
Baillieres Clin Haematol 1992 Jan;5(1):131-42. doi: 10.1016/s0950-3536(11)80038-7. PMID: 1596589
Immunologic transfusion reactions.
Högman CF
Acta Anaesthesiol Scand Suppl 1988;89:4-12. doi: 10.1111/j.1399-6576.1988.tb02835.x. PMID: 3067489

Clinical prediction guides

Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.
Páez M, Jiménez M, Corredor A
Biomedica 2021 Dec 15;41(4):643-650. doi: 10.7705/biomedica.5930. PMID: 34936250Free PMC Article
ABO-incompatible heart transplantation.
Urschel S, West LJ
Curr Opin Pediatr 2016 Oct;28(5):613-9. doi: 10.1097/MOP.0000000000000398. PMID: 27379804Free PMC Article
ABO-incompatible kidney transplantation.
Takahashi K, Saito K
Transplant Rev (Orlando) 2013 Jan;27(1):1-8. Epub 2012 Aug 15 doi: 10.1016/j.trre.2012.07.003. PMID: 22902167
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643

Recent systematic reviews

Success rate and safety of living donor kidney transplantation in ABO blood group incompatible relatives: A systematic review and meta-analysis.
Xu P, Zhao N, Wang J
Transpl Immunol 2023 Dec;81:101921. Epub 2023 Aug 28 doi: 10.1016/j.trim.2023.101921. PMID: 37648033
Clinical outcomes after ABO-incompatible liver transplantation: A systematic review and meta-analysis.
Gan K, Li Z, Bao S, Fang Y, Wang T, Jin L, Ma M, Deng L, Peng Y, Li N, Zeng Z, Huang H
Transpl Immunol 2021 Dec;69:101476. Epub 2021 Oct 1 doi: 10.1016/j.trim.2021.101476. PMID: 34601097
Noninvasive Fetal RhD Blood Group Genotyping: A Systematic Review of Economic Evaluations.
Gajic-Veljanoski O, Li C, Schaink AK, Guo J, Higgins C, Shehata N, Okun N, de Vrijer B, Pechlivanoglou P, Ng V, Sikich N
J Obstet Gynaecol Can 2021 Dec;43(12):1416-1425.e5. Epub 2021 Aug 11 doi: 10.1016/j.jogc.2021.07.014. PMID: 34390866
Red blood cell alloimmunization in transfused patients in sub-Saharan Africa: A systematic review and meta-analysis.
Ngoma AM, Mutombo PB, Ikeda K, Nollet KE, Natukunda B, Ohto H
Transfus Apher Sci 2016 Apr;54(2):296-302. Epub 2015 Nov 5 doi: 10.1016/j.transci.2015.10.017. PMID: 26597314
A systematic review of the use of rituximab for desensitization in renal transplantation.
Macklin PS, Morris PJ, Knight SR
Transplantation 2014 Oct 27;98(8):794-805. doi: 10.1097/TP.0000000000000362. PMID: 25321163

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