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Bipolar depression

MedGen UID:
585
•Concept ID:
C0005587
•
Mental or Behavioral Dysfunction
Synonyms: Bipolar Depression; Depression, Bipolar
SNOMED CT: Bipolar affective disorder, current episode depression (191627008); Manic-depressive - now depressed (191627008)
 
Monarch Initiative: MONDO:0024613

Definition

The depressive stage of bipolar disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBipolar depression

Professional guidelines

PubMed

Diagnosis and management of bipolar disorders.
Goes FS
BMJ 2023 Apr 12;381:e073591. doi: 10.1136/bmj-2022-073591. PMID: 37045450
Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment.
Arnold I, Dehning J, Grunze A, Hausmann A
Medicina (Kaunas) 2021 Jun 8;57(6) doi: 10.3390/medicina57060587. PMID: 34201098Free PMC Article
Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment.
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V
Psychother Psychosom 2021;90(3):160-177. Epub 2020 Nov 9 doi: 10.1159/000511348. PMID: 33166960

Recent clinical studies

Etiology

Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis.
Yildiz A, Siafis S, Mavridis D, Vieta E, Leucht S
Lancet Psychiatry 2023 Sep;10(9):693-705. doi: 10.1016/S2215-0366(23)00199-2. PMID: 37595997
Distinguishing between depression in bipolar disorder and unipolar depression using magnetic resonance imaging: a systematic review.
Siegel-Ramsay JE, Bertocci MA, Wu B, Phillips ML, Strakowski SM, Almeida JRC
Bipolar Disord 2022 Aug;24(5):474-498. Epub 2022 Jan 30 doi: 10.1111/bdi.13176. PMID: 35060259
Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment.
Arnold I, Dehning J, Grunze A, Hausmann A
Medicina (Kaunas) 2021 Jun 8;57(6) doi: 10.3390/medicina57060587. PMID: 34201098Free PMC Article
Comparative efficacy and tolerability of pharmacological treatments for the treatment of acute bipolar depression: A systematic review and network meta-analysis.
Bahji A, Ermacora D, Stephenson C, Hawken ER, Vazquez G
J Affect Disord 2020 May 15;269:154-184. Epub 2020 Mar 20 doi: 10.1016/j.jad.2020.03.030. PMID: 32339131
Bipolar depression: the clinical characteristics and unmet needs of a complex disorder.
McIntyre RS, Calabrese JR
Curr Med Res Opin 2019 Nov;35(11):1993-2005. Epub 2019 Aug 5 doi: 10.1080/03007995.2019.1636017. PMID: 31311335

Diagnosis

Bipolar disorder: Diagnosis, treatment and future directions.
Lane NM, Smith DJ
J R Coll Physicians Edinb 2023 Sep;53(3):192-196. Epub 2023 Aug 30 doi: 10.1177/14782715231197577. PMID: 37649414
Distinguishing between depression in bipolar disorder and unipolar depression using magnetic resonance imaging: a systematic review.
Siegel-Ramsay JE, Bertocci MA, Wu B, Phillips ML, Strakowski SM, Almeida JRC
Bipolar Disord 2022 Aug;24(5):474-498. Epub 2022 Jan 30 doi: 10.1111/bdi.13176. PMID: 35060259
Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses.
Fountoulakis KN, Tohen M, Zarate CA Jr
Eur Neuropsychopharmacol 2022 Jan;54:100-115. doi: 10.1016/j.euroneuro.2021.10.003. PMID: 34980362Free PMC Article
Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment.
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V
Psychother Psychosom 2021;90(3):160-177. Epub 2020 Nov 9 doi: 10.1159/000511348. PMID: 33166960
Bipolar depression: the clinical characteristics and unmet needs of a complex disorder.
McIntyre RS, Calabrese JR
Curr Med Res Opin 2019 Nov;35(11):1993-2005. Epub 2019 Aug 5 doi: 10.1080/03007995.2019.1636017. PMID: 31311335

Therapy

Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses.
Fountoulakis KN, Tohen M, Zarate CA Jr
Eur Neuropsychopharmacol 2022 Jan;54:100-115. doi: 10.1016/j.euroneuro.2021.10.003. PMID: 34980362Free PMC Article
Comparative efficacy and tolerability of pharmacological treatments for the treatment of acute bipolar depression: A systematic review and network meta-analysis.
Bahji A, Ermacora D, Stephenson C, Hawken ER, Vazquez G
J Affect Disord 2020 May 15;269:154-184. Epub 2020 Mar 20 doi: 10.1016/j.jad.2020.03.030. PMID: 32339131
Ketamine and depression: a narrative review.
Corriger A, Pickering G
Drug Des Devel Ther 2019;13:3051-3067. Epub 2019 Aug 27 doi: 10.2147/DDDT.S221437. PMID: 31695324Free PMC Article
Use of Stimulants in Bipolar Disorder.
Perugi G, Vannucchi G, Bedani F, Favaretto E
Curr Psychiatry Rep 2017 Jan;19(1):7. doi: 10.1007/s11920-017-0758-x. PMID: 28144880
Diagnosis, Epidemiology and Management of Mixed States in Bipolar Disorder.
Fagiolini A, Coluccia A, Maina G, Forgione RN, Goracci A, Cuomo A, Young AH
CNS Drugs 2015 Sep;29(9):725-40. doi: 10.1007/s40263-015-0275-6. PMID: 26369921

Prognosis

Bipolar disorder: Diagnosis, treatment and future directions.
Lane NM, Smith DJ
J R Coll Physicians Edinb 2023 Sep;53(3):192-196. Epub 2023 Aug 30 doi: 10.1177/14782715231197577. PMID: 37649414
Diagnosis and management of bipolar disorders.
Goes FS
BMJ 2023 Apr 12;381:e073591. doi: 10.1136/bmj-2022-073591. PMID: 37045450
Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment.
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V
Psychother Psychosom 2021;90(3):160-177. Epub 2020 Nov 9 doi: 10.1159/000511348. PMID: 33166960
Treating Circadian Rhythm Disruption in Bipolar Disorder.
Gold AK, Kinrys G
Curr Psychiatry Rep 2019 Mar 2;21(3):14. doi: 10.1007/s11920-019-1001-8. PMID: 30826893Free PMC Article
Depression and Mania in Bipolar Disorder.
Tondo L, Vázquez GH, Baldessarini RJ
Curr Neuropharmacol 2017 Apr;15(3):353-358. doi: 10.2174/1570159X14666160606210811. PMID: 28503106Free PMC Article

Clinical prediction guides

Well-Being Therapy for Depression.
Romanazzo S, Cosci F
Adv Exp Med Biol 2024;1456:273-290. doi: 10.1007/978-981-97-4402-2_14. PMID: 39261434
The Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression.
Zengin G, Topak OZ, Atesci O, Culha Atesci F
Psychiatr Danub 2022 Summer;34(2):236-244. doi: 10.24869/psyd.2022.236. PMID: 35772133
Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo-Controlled Clinical Trial.
Calkin CV, Chengappa KNR, Cairns K, Cookey J, Gannon J, Alda M, O'Donovan C, Reardon C, Sanches M, Růzicková M
J Clin Psychiatry 2022 Feb 1;83(2) doi: 10.4088/JCP.21m14022. PMID: 35120288
Efficacy and tolerability of atypical antipsychotics for acute bipolar depression: a network meta-analysis.
Kadakia A, Dembek C, Heller V, Singh R, Uyei J, Hagi K, Nosaka T, Loebel A
BMC Psychiatry 2021 May 11;21(1):249. doi: 10.1186/s12888-021-03220-3. PMID: 33975574Free PMC Article
Bipolar disorder.
Geddes JR, Briess D
BMJ Clin Evid 2007 Aug 1;2007 PMID: 19454110Free PMC Article

Recent systematic reviews

Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis.
Yildiz A, Siafis S, Mavridis D, Vieta E, Leucht S
Lancet Psychiatry 2023 Sep;10(9):693-705. doi: 10.1016/S2215-0366(23)00199-2. PMID: 37595997
Oral ketamine for depression: An updated systematic review.
Meshkat S, Haikazian S, Di Vincenzo JD, Fancy F, Johnson D, Chen-Li D, McIntyre RS, Mansur R, Rosenblat JD
World J Biol Psychiatry 2023 Sep-Oct;24(7):545-557. Epub 2023 Jan 31 doi: 10.1080/15622975.2023.2169349. PMID: 36651238
The serotonin theory of depression: a systematic umbrella review of the evidence.
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA
Mol Psychiatry 2023 Aug;28(8):3243-3256. Epub 2022 Jul 20 doi: 10.1038/s41380-022-01661-0. PMID: 35854107Free PMC Article
Lithium treatment of Bipolar disorder in adults: A systematic review of randomized trials and meta-analyses.
Fountoulakis KN, Tohen M, Zarate CA Jr
Eur Neuropsychopharmacol 2022 Jan;54:100-115. doi: 10.1016/j.euroneuro.2021.10.003. PMID: 34980362Free PMC Article
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235

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