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Decreased circulating vitamin C concentration

MedGen UID:
2093
•Concept ID:
C0003969
•
Disease or Syndrome
Synonym: Ascorbic acid deficiency
SNOMED CT: Ascorbic acid deficiency (76169001); Vitamin C deficiency (76169001); Deficiency of ascorbic acid (76169001)
 
HPO: HP:0100510

Definition

The concentration of vitamin C in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating vitamin C concentration

Recent clinical studies

Therapy

Risk of Hypovitaminosis and Vitamin C Deficiency in Pediatric Patients Undergoing Cardiopulmonary Bypass.
Al-Subu AM, Long MT, Nelson KL, Amond KL, Lasarev MR, Ferrazzano PA, Lushaj EB, Anagnostopoulos PV
Pediatr Cardiol 2023 Oct;44(7):1487-1494. Epub 2023 Jul 27 doi: 10.1007/s00246-023-03243-5. PMID: 37498330
Antioxidant activity of Lactobacillus plantarum NJAU-01 in an animal model of aging.
Ge Q, Yang B, Liu R, Jiang D, Yu H, Wu M, Zhang W
BMC Microbiol 2021 Jun 15;21(1):182. doi: 10.1186/s12866-021-02248-5. PMID: 34130624Free PMC Article
Vitamin C in sepsis.
Wilson JX, Wu F
Subcell Biochem 2012;56:67-83. doi: 10.1007/978-94-007-2199-9_5. PMID: 22116695
Dietary factors and low-grade inflammation in relation to overweight and obesity.
Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, Esposito K, Jönsson LS, Kolb H, Lansink M, Marcos A, Margioris A, Matusheski N, Nordmann H, O'Brien J, Pugliese G, Rizkalla S, Schalkwijk C, Tuomilehto J, Wärnberg J, Watzl B, Winklhofer-Roob BM
Br J Nutr 2011 Dec;106 Suppl 3:S5-78. doi: 10.1017/S0007114511005460. PMID: 22133051
Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.
Wilson JX
Biofactors 2009 Jan-Feb;35(1):5-13. doi: 10.1002/biof.7. PMID: 19319840Free PMC Article

Prognosis

Maternal Prenatal Hair Cortisol Is Associated with Child Wheeze among Mothers and Infants with Tobacco Smoke Exposure and Who Face High Socioeconomic Adversity.
Scherman A, Spindel ER, Park B, Tepper R, Erikson DW, Morris C, McEvoy CT
Int J Environ Res Public Health 2021 Mar 9;18(5) doi: 10.3390/ijerph18052764. PMID: 33803272Free PMC Article
Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population.
Lam TK, Freedman ND, Fan JH, Qiao YL, Dawsey SM, Taylor PR, Abnet CC
Am J Clin Nutr 2013 Nov;98(5):1289-97. Epub 2013 Sep 11 doi: 10.3945/ajcn.113.061267. PMID: 24025629Free PMC Article
Socioeconomic status, antioxidant micronutrients, and correlates of oxidative damage: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Janicki-Deverts D, Cohen S, Matthews KA, Gross MD, Jacobs DR Jr
Psychosom Med 2009 Jun;71(5):541-8. Epub 2009 May 4 doi: 10.1097/PSY.0b013e31819e7526. PMID: 19414620Free PMC Article
Impact of C-reactive protein on disease risk and its relation to dietary factors.
Nanri A, Moore MA, Kono S
Asian Pac J Cancer Prev 2007 Apr-Jun;8(2):167-77. PMID: 17696726
Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk.
Borrelli E, Roux-Lombard P, Grau GE, Girardin E, Ricou B, Dayer J, Suter PM
Crit Care Med 1996 Mar;24(3):392-7. doi: 10.1097/00003246-199603000-00006. PMID: 8625625

Clinical prediction guides

Risk of Hypovitaminosis and Vitamin C Deficiency in Pediatric Patients Undergoing Cardiopulmonary Bypass.
Al-Subu AM, Long MT, Nelson KL, Amond KL, Lasarev MR, Ferrazzano PA, Lushaj EB, Anagnostopoulos PV
Pediatr Cardiol 2023 Oct;44(7):1487-1494. Epub 2023 Jul 27 doi: 10.1007/s00246-023-03243-5. PMID: 37498330
Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial.
Rozemeijer S, de Grooth HJ, Elbers PWG, Girbes ARJ, den Uil CA, Dubois EA, Wils EJ, Rettig TCD, van Zanten ARH, Vink R, van den Bogaard B, Bosman RJ, Oudemans-van Straaten HM, de Man AME
Trials 2021 Aug 18;22(1):546. doi: 10.1186/s13063-021-05483-3. PMID: 34407846Free PMC Article
Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation.
Rodemeister S, Duquesne M, Adolph M, Nohr D, Biesalski HK, Unertl K
Nutrition 2014 Jun;30(6):673-8. Epub 2013 Nov 6 doi: 10.1016/j.nut.2013.10.026. PMID: 24631388
Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.
Wilson JX
Biofactors 2009 Jan-Feb;35(1):5-13. doi: 10.1002/biof.7. PMID: 19319840Free PMC Article
Impact of C-reactive protein on disease risk and its relation to dietary factors.
Nanri A, Moore MA, Kono S
Asian Pac J Cancer Prev 2007 Apr-Jun;8(2):167-77. PMID: 17696726

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