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Psoriatic arthritis

MedGen UID:
2077
•Concept ID:
C0003872
•
Disease or Syndrome
Synonyms: Arthritic Psoriasis; Arthritis, Psoriatic; Arthropathies, Psoriatic; Arthropathy, Psoriatic; Psoriasis Arthropathica; Psoriasis, Arthritic; Psoriatic Arthritis; Psoriatic Arthropathies; Psoriatic Arthropathy
SNOMED CT: Psoriatic arthritis (156370009); PsA (Psoriatic arthritis) (156370009); PA (Psoriatic arthritis) (156370009)
 
Monarch Initiative: MONDO:0011849
Orphanet: ORPHA40050

Definition

Joint inflammation associated with psoriasis. [from NCI]

Professional guidelines

PubMed

EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update.
Gossec L, Kerschbaumer A, Ferreira RJO, Aletaha D, Baraliakos X, Bertheussen H, Boehncke WH, Esbensen BA, McInnes IB, McGonagle D, Winthrop KL, Balanescu A, Balint PV, Burmester GR, Cañete JD, Claudepierre P, Eder L, Hetland ML, Iagnocco A, Kristensen LE, Lories R, Queiro R, Mauro D, Marzo-Ortega H, Mease PJ, Nash P, Wagenaar W, Savage L, Schett G, Shoop-Worrall SJW, Tanaka Y, Van den Bosch FE, van der Helm-van Mil A, Zabotti A, van der Heijde D, Smolen JS
Ann Rheum Dis 2024 May 15;83(6):706-719. doi: 10.1136/ard-2024-225531. PMID: 38499325Free PMC Article
The updated GRAPPA and EULAR recommendations for the management of psoriatic arthritis: Similarities and differences.
Coates L, Gossec L
Joint Bone Spine 2023 Jan;90(1):105469. Epub 2022 Sep 29 doi: 10.1016/j.jbspin.2022.105469. PMID: 36184036
Treatment guidelines in psoriatic arthritis.
Ogdie A, Coates LC, Gladman DD
Rheumatology (Oxford) 2020 Mar 1;59(Suppl 1):i37-i46. doi: 10.1093/rheumatology/kez383. PMID: 32159790Free PMC Article

Recent clinical studies

Etiology

Psoriatic arthritis.
López-Ferrer A, Laiz A, Puig L
Med Clin (Barc) 2022 Jul 8;159(1):40-46. Epub 2022 May 4 doi: 10.1016/j.medcli.2022.01.024. PMID: 35525675
GRAPPA Treatment Recommendations: 2021 Update.
Coates LC, Corp N, van der Windt DA, O'Sullivan D, Soriano ER, Kavanaugh A
J Rheumatol 2022 Jun;49(6 Suppl 1):52-54. Epub 2022 Mar 15 doi: 10.3899/jrheum.211331. PMID: 35293339
Pathogenesis of psoriatic arthritis.
Stober C
Best Pract Res Clin Rheumatol 2021 Jun;35(2):101694. Epub 2021 Jun 6 doi: 10.1016/j.berh.2021.101694. PMID: 34108102
Treatment guidelines in psoriatic arthritis.
Ogdie A, Coates LC, Gladman DD
Rheumatology (Oxford) 2020 Mar 1;59(Suppl 1):i37-i46. doi: 10.1093/rheumatology/kez383. PMID: 32159790Free PMC Article
The Epidemiology of Psoriatic Arthritis.
Ogdie A, Weiss P
Rheum Dis Clin North Am 2015 Nov;41(4):545-68. Epub 2015 Sep 11 doi: 10.1016/j.rdc.2015.07.001. PMID: 26476218Free PMC Article

Diagnosis

The updated GRAPPA and EULAR recommendations for the management of psoriatic arthritis: Similarities and differences.
Coates L, Gossec L
Joint Bone Spine 2023 Jan;90(1):105469. Epub 2022 Sep 29 doi: 10.1016/j.jbspin.2022.105469. PMID: 36184036
Psoriatic arthritis.
López-Ferrer A, Laiz A, Puig L
Med Clin (Barc) 2022 Jul 8;159(1):40-46. Epub 2022 May 4 doi: 10.1016/j.medcli.2022.01.024. PMID: 35525675
Psoriatic arthritis.
Ocampo D V, Gladman D
F1000Res 2019;8 Epub 2019 Sep 20 doi: 10.12688/f1000research.19144.1. PMID: 31583079Free PMC Article
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
Psoriatic arthritis: state of the art review.
Coates LC, Helliwell PS
Clin Med (Lond) 2017 Feb;17(1):65-70. doi: 10.7861/clinmedicine.17-1-65. PMID: 28148584Free PMC Article

Therapy

The role of IL-23 and the use of IL-23 inhibitors in psoriatic arthritis.
Fragoulis GE, Siebert S
Musculoskeletal Care 2022 Nov;20 Suppl 1(Suppl 1):S12-S21. Epub 2022 Sep 7 doi: 10.1002/msc.1694. PMID: 36069174Free PMC Article
Long-term Safety of Secukinumab Over Five Years in Patients with Moderate-to-severe Plaque Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis: Update on Integrated Pooled Clinical Trial and Post-marketing Surveillance Data.
Gottlieb AB, Deodhar A, Mcinnes IB, Baraliakos X, Reich K, Schreiber S, Bao W, Marfo K, Richards HB, Pricop L, Shete A, Trivedi V, Keefe D, Papavassilis CC, Jagiello P, Papanastasiou P, Mease PJ, Lebwohl M
Acta Derm Venereol 2022 Apr 27;102:adv00698. doi: 10.2340/actadv.v102.563. PMID: 35146532Free PMC Article
Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2.
Mease PJ, Lertratanakul A, Anderson JK, Papp K, Van den Bosch F, Tsuji S, Dokoupilova E, Keiserman M, Wang X, Zhong S, McCaskill RM, Zueger P, Pangan AL, Tillett W
Ann Rheum Dis 2021 Mar;80(3):312-320. Epub 2020 Dec 3 doi: 10.1136/annrheumdis-2020-218870. PMID: 33272960Free PMC Article
Paradoxical gastrointestinal effects of interleukin-17 blockers.
Fauny M, Moulin D, D'Amico F, Netter P, Petitpain N, Arnone D, Jouzeau JY, Loeuille D, Peyrin-Biroulet L
Ann Rheum Dis 2020 Sep;79(9):1132-1138. Epub 2020 Jul 21 doi: 10.1136/annrheumdis-2020-217927. PMID: 32719044
Tofacitinib for the treatment of psoriasis and psoriatic arthritis.
Berekmeri A, Mahmood F, Wittmann M, Helliwell P
Expert Rev Clin Immunol 2018 Sep;14(9):719-730. doi: 10.1080/1744666X.2018.1512404. PMID: 30118353

Prognosis

Efficacy and safety of Janus kinase inhibitors in patients with psoriasis and psoriatic arthritis: a systematic review and meta-analysis.
Yang F, Lu C, Wang Y, Liu H, Leng X, Zeng X
Clin Rheumatol 2023 Jun;42(6):1593-1605. Epub 2023 Feb 10 doi: 10.1007/s10067-023-06529-4. PMID: 36763226
Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis.
Vaengebjerg S, Skov L, Egeberg A, Loft ND
JAMA Dermatol 2020 Apr 1;156(4):421-429. doi: 10.1001/jamadermatol.2020.0024. PMID: 32074260Free PMC Article
Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation-data from the prospective IVEPSA study.
Kampylafka E, Simon D, d'Oliveira I, Linz C, Lerchen V, Englbrecht M, Rech J, Kleyer A, Sticherling M, Schett G, Hueber AJ
Arthritis Res Ther 2019 Jul 26;21(1):178. doi: 10.1186/s13075-019-1957-0. PMID: 31349876Free PMC Article
Seronegative spondyloarthritis.
Zochling J, Smith EU
Best Pract Res Clin Rheumatol 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002. PMID: 21665123
Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study.
Wilson FC, Icen M, Crowson CS, McEvoy MT, Gabriel SE, Kremers HM
Arthritis Rheum 2009 Feb 15;61(2):233-9. doi: 10.1002/art.24172. PMID: 19177544Free PMC Article

Clinical prediction guides

Long-Term Efficacy and Safety of Guselkumab, a Monoclonal Antibody Specific to the p19 Subunit of Interleukin-23, Through Two Years: Results From a Phase III, Randomized, Double-Blind, Placebo-Controlled Study Conducted in Biologic-Naive Patients With Active Psoriatic Arthritis.
McInnes IB, Rahman P, Gottlieb AB, Hsia EC, Kollmeier AP, Xu XL, Jiang Y, Sheng S, Shawi M, Chakravarty SD, van der Heijde D, Mease PJ
Arthritis Rheumatol 2022 Mar;74(3):475-485. Epub 2022 Feb 7 doi: 10.1002/art.42010. PMID: 34719872Free PMC Article
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative.
Balint PV, Terslev L, Aegerter P, Bruyn GAW, Chary-Valckenaere I, Gandjbakhch F, Iagnocco A, Jousse-Joulin S, Möller I, Naredo E, Schmidt WA, Wakefield RJ, D'Agostino MA; OMERACT Ultrasound Task Force members
Ann Rheum Dis 2018 Dec;77(12):1730-1735. Epub 2018 Aug 3 doi: 10.1136/annrheumdis-2018-213609. PMID: 30076154
Psoriatic arthritis indices.
Schoels M
Clin Exp Rheumatol 2014 Sep-Oct;32(5 Suppl 85):S-109-12. Epub 2014 Oct 30 PMID: 25365098
Synovitis score: discrimination between chronic low-grade and high-grade synovitis.
Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Haupl T
Histopathology 2006 Oct;49(4):358-64. doi: 10.1111/j.1365-2559.2006.02508.x. PMID: 16978198

Recent systematic reviews

Efficacy and safety of pharmacological treatment of psoriatic arthritis: a systematic literature research informing the 2023 update of the EULAR recommendations for the management of psoriatic arthritis.
Kerschbaumer A, Smolen JS, Ferreira RJO, Bertheussen H, Baraliakos X, Aletaha D, McGonagle DG, van der Heijde D, McInnes IB, Esbensen BA, Winthrop KL, Boehncke WH, Schoones JW, Gossec L
Ann Rheum Dis 2024 May 15;83(6):760-774. doi: 10.1136/ard-2024-225534. PMID: 38503473Free PMC Article
EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update.
Gossec L, Kerschbaumer A, Ferreira RJO, Aletaha D, Baraliakos X, Bertheussen H, Boehncke WH, Esbensen BA, McInnes IB, McGonagle D, Winthrop KL, Balanescu A, Balint PV, Burmester GR, Cañete JD, Claudepierre P, Eder L, Hetland ML, Iagnocco A, Kristensen LE, Lories R, Queiro R, Mauro D, Marzo-Ortega H, Mease PJ, Nash P, Wagenaar W, Savage L, Schett G, Shoop-Worrall SJW, Tanaka Y, Van den Bosch FE, van der Helm-van Mil A, Zabotti A, van der Heijde D, Smolen JS
Ann Rheum Dis 2024 May 15;83(6):706-719. doi: 10.1136/ard-2024-225531. PMID: 38499325Free PMC Article
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.
Sbidian E, Chaimani A, Garcia-Doval I, Doney L, Dressler C, Hua C, Hughes C, Naldi L, Afach S, Le Cleach L
Cochrane Database Syst Rev 2022 May 23;5(5):CD011535. doi: 10.1002/14651858.CD011535.pub5. PMID: 35603936Free PMC Article
Measuring fatigue: a meta-review.
Machado MO, Kang NC, Tai F, Sambhi RDS, Berk M, Carvalho AF, Chada LP, Merola JF, Piguet V, Alavi A
Int J Dermatol 2021 Sep;60(9):1053-1069. Epub 2020 Dec 10 doi: 10.1111/ijd.15341. PMID: 33301180
Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis.
Vaengebjerg S, Skov L, Egeberg A, Loft ND
JAMA Dermatol 2020 Apr 1;156(4):421-429. doi: 10.1001/jamadermatol.2020.0024. PMID: 32074260Free PMC Article

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