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Arteriovenous malformation

MedGen UID:
2042
Concept ID:
C0003857
Congenital Abnormality
Synonym: AVM
SNOMED CT: AV - Congenital arteriovenous anomaly (234141001); Congenital arteriovenous malformation (234141001); AV - Congenital arteriovenous malformation (234141001); AVM - Congenital arteriovenous malformation (234141001); Arteriovenous malformation (24551003)
 
HPO: HP:0100026

Definition

An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries. [from HPO]

Conditions with this feature

Capillary malformation-arteriovenous malformation 1
MedGen UID:
1648501
Concept ID:
C4747394
Disease or Syndrome
Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is characterized by the presence of multiple small (1-2 cm in diameter) capillary malformations mostly localized on the face and limbs. Some affected individuals also have associated arteriovenous malformations (AVMs) and/or arteriovenous fistulas (AFVs), fast-flow vascular anomalies that typically arise in the skin, muscle, bone, spine, and brain; life-threatening complications of these lesions can include bleeding, congestive heart failure, and/or neurologic consequences. Symptoms from intracranial AVMs/AVFs appear to occur early in life. Several individuals have Parkes Weber syndrome (multiple micro-AVFs associated with a cutaneous capillary stain and excessive soft-tissue and skeletal growth of an affected limb).

Professional guidelines

PubMed

Rosen A, Chan WV, Matelski J, Walsh C, Murji A
Fertil Steril 2021 Oct;116(4):1107-1116. Epub 2021 Jun 12 doi: 10.1016/j.fertnstert.2021.05.095. PMID: 34130801
Sami SS, Al-Araji SA, Ragunath K
Aliment Pharmacol Ther 2014 Jan;39(1):15-34. Epub 2013 Oct 20 doi: 10.1111/apt.12527. PMID: 24138285
Jean-Baptiste E
Crit Care Med 2000 May;28(5):1642-7. doi: 10.1097/00003246-200005000-00066. PMID: 10834728

Recent clinical studies

Etiology

Lau KK, Steinke K, Reis S, Cherukuri SP, Cejna M
Respirology 2022 Aug;27(8):581-599. Epub 2022 Jun 27 doi: 10.1111/resp.14315. PMID: 35758539Free PMC Article
Palit A, Inamadar AC
Indian J Dermatol Venereol Leprol 2022 May-Jun;88(4):452-463. doi: 10.25259/IJDVL_799_20. PMID: 35138057
Rutledge C, Cooke DL, Hetts SW, Abla AA
Handb Clin Neurol 2021;176:171-178. doi: 10.1016/B978-0-444-64034-5.00020-1. PMID: 33272394
Shaligram SS, Winkler E, Cooke D, Su H
CNS Neurosci Ther 2019 Oct;25(10):1085-1095. Epub 2019 Jul 29 doi: 10.1111/cns.13200. PMID: 31359618Free PMC Article
Diaz O, Scranton R
Handb Clin Neurol 2016;136:1311-7. doi: 10.1016/B978-0-444-53486-6.00068-5. PMID: 27430471

Diagnosis

Hoang VT, Van HAT, Trinh CT, Pham NTT, Huynh C, Ha TN, Huynh PH, Nguyen HQ, Vo UG, Nguyen TT
J Endovasc Ther 2021 Oct;28(5):659-675. Epub 2021 Jun 18 doi: 10.1177/15266028211025022. PMID: 34142901
Riina HA
J Neurosurg 2019 Dec 1;131(6):1690-1701. doi: 10.3171/2019.8.JNS182678. PMID: 31786544
Szpera-Goździewicz A, Gruca-Stryjak K, Bręborowicz GH, Ropacka-Lesiak M
Ginekol Pol 2018;89(5):276-279. doi: 10.5603/GP.a2018.0047. PMID: 30084480
Barreau X, Marnat G, Gariel F, Dousset V
Diagn Interv Imaging 2014 Dec;95(12):1175-86. Epub 2014 Nov 24 doi: 10.1016/j.diii.2014.10.004. PMID: 25465120
Chou SC, Shyr YM, Wang SE
J Gastrointest Surg 2013 Jul;17(7):1240-6. Epub 2013 May 2 doi: 10.1007/s11605-013-2217-2. PMID: 23636883

Therapy

Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560
Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, Al-Shahi Salman R, Vicaut E, Young WL, Houdart E, Cordonnier C, Stefani MA, Hartmann A, von Kummer R, Biondi A, Berkefeld J, Klijn CJ, Harkness K, Libman R, Barreau X, Moskowitz AJ; international ARUBA investigators
Lancet 2014 Feb 15;383(9917):614-21. Epub 2013 Nov 20 doi: 10.1016/S0140-6736(13)62302-8. PMID: 24268105Free PMC Article
Gross BA, Thomas AJ, Frerichs KU, Du R
J Clin Neurosci 2013 Jun;20(6):776-82. Epub 2013 Apr 28 doi: 10.1016/j.jocn.2013.03.011. PMID: 23632292

Prognosis

Luther E, McCarthy DJ, Burks J, Govindarajan V, Lu VM, Silva M, Lang M, Gross BA, Starke RM
J Neurointerv Surg 2023 Aug;15(8):735-740. Epub 2022 Jul 28 doi: 10.1136/jnis-2022-019110. PMID: 35902235Free PMC Article
Ganz JC
Prog Brain Res 2022;268(1):75-97. Epub 2022 Jan 13 doi: 10.1016/bs.pbr.2021.10.027. PMID: 35074096
Bernhard SM, Tuleja A, Laine JE, Haupt F, Häberli D, Hügel U, Rössler J, Schindewolf M, Baumgartner I
J Vasc Surg Venous Lymphat Disord 2022 May;10(3):705-712. Epub 2021 Oct 11 doi: 10.1016/j.jvsv.2021.10.002. PMID: 34649003
Hak JF, Boulouis G, Kerleroux B, Benichi S, Stricker S, Gariel F, Garzelli L, Meyer P, Kossorotoff M, Boddaert N, Vidal V, Girard N, Dangouloff-Ros V, Brunelle F, Fullerton H, Hetts SW, Blauwblomme T, Naggara O
J Neurointerv Surg 2022 Jun;14(6):611-617. Epub 2021 Sep 28 doi: 10.1136/neurintsurg-2021-017777. PMID: 34583986
Rutledge C, Cooke DL, Hetts SW, Abla AA
Handb Clin Neurol 2021;176:171-178. doi: 10.1016/B978-0-444-64034-5.00020-1. PMID: 33272394

Clinical prediction guides

Zhang H, Peng H, Yan D, Wang K, Yuan K, Chen Y, Li Z, Li R, Li R, Lu J, Chen X, Ye X, Wang H, Zhao Y, Hao Q
Microvasc Res 2023 Jan;145:104452. Epub 2022 Nov 8 doi: 10.1016/j.mvr.2022.104452. PMID: 36356687
Taweel BA, Gillespie CS, Richardson GE, Mustafa MA, Ali T, Islim AI, Hannan CJ, Chavredakis E
Acta Neurochir (Wien) 2022 Jun;164(6):1685-1692. Epub 2022 Apr 18 doi: 10.1007/s00701-022-05190-1. PMID: 35435515Free PMC Article
Rutledge C, Cooke DL, Hetts SW, Abla AA
Handb Clin Neurol 2021;176:171-178. doi: 10.1016/B978-0-444-64034-5.00020-1. PMID: 33272394
Vilela Chagas Ferreira M, Goldenberg DC, Kharmandayan V, Gemperli R
Laryngoscope 2020 May;130(5):1322-1326. Epub 2019 Jul 29 doi: 10.1002/lary.28209. PMID: 31355963
Shaligram SS, Winkler E, Cooke D, Su H
CNS Neurosci Ther 2019 Oct;25(10):1085-1095. Epub 2019 Jul 29 doi: 10.1111/cns.13200. PMID: 31359618Free PMC Article

Recent systematic reviews

Scalia G, Umana GE, Crea A, Vats A, Chaurasia B, Graziano F, Marrone S, Furnari M, Ponzo G, Giuffrida M, Fricia M, Cicero S, Nicoletti GF
Br J Neurosurg 2023 Oct;37(5):1000-1005. Epub 2022 Jan 8 doi: 10.1080/02688697.2021.2024499. PMID: 35001775
El-Abtah ME, Petitt JC, Kashkoush A, Achey R, Bain MD, Moore NZ
World Neurosurg 2022 Aug;164:257-269. Epub 2022 May 18 doi: 10.1016/j.wneu.2022.05.051. PMID: 35597540
Rosen A, Chan WV, Matelski J, Walsh C, Murji A
Fertil Steril 2021 Oct;116(4):1107-1116. Epub 2021 Jun 12 doi: 10.1016/j.fertnstert.2021.05.095. PMID: 34130801
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560

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