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Aleutian disease

MedGen UID:
193
•Concept ID:
C0002016
•
Disease or Syndrome
Synonyms: Aleutian Disease of Mink; Aleutian Mink Disease; Disease, Aleutian Mink; Mink Disease, Aleutian
SNOMED CT: Aleutian disease (62251004); Aleutian mink disease (62251004)

Definition

A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAleutian disease

Recent clinical studies

Etiology

Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison).
Vahedi SM, Salek Ardestani S, Banabazi MH, Clark KF
Sci Rep 2024 Jan 10;14(1):1035. doi: 10.1038/s41598-023-51039-7. PMID: 38200094Free PMC Article

Diagnosis

Diseases and disorders of muscle.
Pearson AM, Young RB
Adv Food Nutr Res 1993;37:339-423. doi: 10.1016/s1043-4526(08)60119-9. PMID: 8398047
Inhibition of precipitation in counter current electrophoresis. A sensitive method for detection of mink antibodies to Aleutian disease virus.
Aasted B, Cohn A
Acta Pathol Microbiol Immunol Scand C 1982 Feb;90(1):15-9. doi: 10.1111/j.1699-0463.1982.tb01411.x. PMID: 7080835
Some final comments on visna-maedi aleutian disease and scrapie.
Kimberlin RH
Front Biol 1976;44:383-95. PMID: 182561

Clinical prediction guides

The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infection.
Cheng F, Chen AY, Best SM, Bloom ME, Pintel D, Qiu J
J Virol 2010 Mar;84(6):2687-96. Epub 2009 Dec 30 doi: 10.1128/JVI.01917-09. PMID: 20042496Free PMC Article
'Nuclear' antigens and antinuclear antibodies in mink sera.
Barnett EV, Williams RC Jr, Kenyon AJ, Henson JE
Immunology 1969 Feb;16(2):241-53. PMID: 4181511Free PMC Article

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