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AIDS related complex

MedGen UID:
1793
•Concept ID:
C0001857
•
Disease or Syndrome
Synonyms: AIDS Related Complex; AIDS-Related Complex; ARC; Complex, AIDS-Related; Lymphadenopathy Syndrome; Lymphadenopathy Syndromes; Syndrome, Lymphadenopathy; Syndromes, Lymphadenopathy
 
Monarch Initiative: MONDO:0005639

Definition

A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating aids-related complex (ARC) from aids include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in aids; follicular or mixed hyperplasia in arc lymph nodes, leading to lymphocyte degeneration and depletion more typical of aids; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown aids. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAIDS related complex

Professional guidelines

PubMed

Trichosanthin treatment of HIV-induced immune dysregulation.
Mayer RA, Sergios PA, Coonan K, O'Brien L
Eur J Clin Invest 1992 Feb;22(2):113-22. doi: 10.1111/j.1365-2362.1992.tb01944.x. PMID: 1572389
Oral dextran sulfate (UA001) in the treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.
Abrams DI, Kuno S, Wong R, Jeffords K, Nash M, Molaghan JB, Gorter R, Ueno R
Ann Intern Med 1989 Feb 1;110(3):183-8. doi: 10.7326/0003-4819-110-3-183. PMID: 2463780
Thymostimulin treatment in AIDS-related complex.
Palmisano L, Chisesi T, Galli M, Gritti FM, Ielasi G, Lazzarin A, Mezzaroma I, Moroni M, Raise E, Vaglia A
Clin Immunol Immunopathol 1988 Jun;47(3):253-61. doi: 10.1016/s0090-1229(88)80003-5. PMID: 3259480

Recent clinical studies

Etiology

The changing face of HIV/AIDS in treated patients.
Llibre JM, Falco V, Tural C, Negredo E, Pineda JA, Muñoz J, Ortega E, Videla S, Sirera G, Martinez E, Miralles C, Iribarren J, Galindo MJ, Domingo P, d'Arminio-Monforte A, Miro JM, Clotet B
Curr HIV Res 2009 Jul;7(4):365-77. doi: 10.2174/157016209788680633. PMID: 19601771
Human immunodeficiency virus and the central nervous system.
de Almeida SM, Letendre S, Ellis R
Braz J Infect Dis 2006 Feb;10(1):41-50. Epub 2006 Jun 2 doi: 10.1590/s1413-86702006000100009. PMID: 16767315
Immunohistopathogenesis of persistent generalized lymphadenopathy in HIV-positive patients.
Baroni CD, Vitolo D, Uccini S
Ric Clin Lab 1990 Jan-Mar;20(1):1-10. doi: 10.1007/BF02910143. PMID: 2192430
High-dose intravenous immunoglobulins in HIV-1-infected adults with AIDS-related complex and Walter-Reed 5.
Schrappe-Bächer M, Rasokat H, Bauer P, Bendick C, Bube FW, Degenhardt S, Fätkenheuer G, Heiniger HJ, Heitmann K, Imbach P
Vox Sang 1990;59 Suppl 1:3-14. doi: 10.1111/j.1423-0410.1990.tb01637.x. PMID: 1978443
Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS.
Biberfeld P, Ost A, Porwit A, Sandstedt B, Pallesen G, Böttiger B, Morfelt-Månsson L, Biberfeld G
Acta Pathol Microbiol Immunol Scand A 1987 Jan;95(1):47-65. doi: 10.1111/j.1699-0463.1987.tb00009_95a.x. PMID: 2435107

Diagnosis

The changing face of HIV/AIDS in treated patients.
Llibre JM, Falco V, Tural C, Negredo E, Pineda JA, Muñoz J, Ortega E, Videla S, Sirera G, Martinez E, Miralles C, Iribarren J, Galindo MJ, Domingo P, d'Arminio-Monforte A, Miro JM, Clotet B
Curr HIV Res 2009 Jul;7(4):365-77. doi: 10.2174/157016209788680633. PMID: 19601771
Pathology of AIDS in children.
Joshi VV
Indian J Pediatr 1994 Sep-Oct;61(5):497-512. doi: 10.1007/BF02751710. PMID: 7744451
AIDS.
Murphy RL, Phair JP
Compr Ther 1988 Jan;14(1):3-12. PMID: 3277764
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217
The pathology of AIDS.
Macher AM
Public Health Rep 1988 May-Jun;103(3):246-54. PMID: 2836878Free PMC Article

Therapy

The changing face of HIV/AIDS in treated patients.
Llibre JM, Falco V, Tural C, Negredo E, Pineda JA, Muñoz J, Ortega E, Videla S, Sirera G, Martinez E, Miralles C, Iribarren J, Galindo MJ, Domingo P, d'Arminio-Monforte A, Miro JM, Clotet B
Curr HIV Res 2009 Jul;7(4):365-77. doi: 10.2174/157016209788680633. PMID: 19601771
Metabolism of Zidovudine.
Veal GJ, Back DJ
Gen Pharmacol 1995 Nov;26(7):1469-75. doi: 10.1016/0306-3623(95)00047-x. PMID: 8690233
Zidovudine intolerance.
Groopman JE
Rev Infect Dis 1990 Jul-Aug;12 Suppl 5:S500-6. doi: 10.1093/clinids/12.supplement_5.s500. PMID: 2201071
Zidovudine update: 1990.
Morse GD, Lechner JL, Santora JA, Rozek SL
DICP 1990 Jul-Aug;24(7-8):754-60. doi: 10.1177/106002809002400720. PMID: 2197818
Odynophagia/dysphagia in AIDS.
Raufman JP
Gastroenterol Clin North Am 1988 Sep;17(3):599-614. PMID: 3049365

Prognosis

HIV/AIDS-related hyponatremia: an old but still serious problem.
Shu Z, Tian Z, Chen J, Ma J, Abudureyimu A, Qian Q, Zhuo L
Ren Fail 2018 Nov;40(1):68-74. doi: 10.1080/0886022X.2017.1419975. PMID: 29299949Free PMC Article
The epidemiology of acquired immunodeficiency syndrome and associated tumours in Europe.
Serraino D, Franceschi S, Tirelli U, Monfardini S
Ann Oncol 1992 Sep;3(8):595-603. doi: 10.1093/oxfordjournals.annonc.a058283. PMID: 1450040
Photopheresis: a clinically relevant immunobiologic response modifier.
Edelson RL
Ann N Y Acad Sci 1991 Dec 30;636:154-64. doi: 10.1111/j.1749-6632.1991.tb33446.x. PMID: 1793205
AIDS.
Murphy RL, Phair JP
Compr Ther 1988 Jan;14(1):3-12. PMID: 3277764
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217

Clinical prediction guides

The epidemiology of acquired immunodeficiency syndrome and associated tumours in Europe.
Serraino D, Franceschi S, Tirelli U, Monfardini S
Ann Oncol 1992 Sep;3(8):595-603. doi: 10.1093/oxfordjournals.annonc.a058283. PMID: 1450040
Photopheresis: a clinically relevant immunobiologic response modifier.
Edelson RL
Ann N Y Acad Sci 1991 Dec 30;636:154-64. doi: 10.1111/j.1749-6632.1991.tb33446.x. PMID: 1793205
Pregnancy and AIDS.
Henrion R
Hum Reprod 1988 Feb;3(2):257-62. doi: 10.1093/oxfordjournals.humrep.a136689. PMID: 3281969
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217
A clinical-immunological evaluation of AIDS cases and related syndromes.
Gritti FM, Raise E, Gualandi G, Bonazzi L, Martuzzi M, Schiattone ML, Di Pede B, Gallo R, Rivano MT, Taruscio D
J Exp Pathol 1987 Summer;3(4):723-36. PMID: 3483882

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