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Spontaneous Abortion

MedGen UID:
39
Concept ID:
C0000786
Finding; Pathologic Function
Synonyms: Abortion, Spontaneous; Abortions, Spontaneous; Spontaneous Abortions

Definition

Fetal loss at less than 20 weeks of gestation. [from NCI]

Professional guidelines

PubMed

Viotti M, Greco E, Grifo JA, Madjunkov M, Librach C, Cetinkaya M, Kahraman S, Yakovlev P, Kornilov N, Corti L, Biricik A, Cheng EH, Su CY, Lee MS, Bonifacio MD, Cooper AR, Griffin DK, Tran DY, Kaur P, Barnes FL, Zouves CG, Victor AR, Besser AG, Madjunkova S, Spinella F
Fertil Steril 2023 Nov;120(5):957-966. Epub 2023 Jul 31 doi: 10.1016/j.fertnstert.2023.07.022. PMID: 37532168
Nyirjesy P, Brookhart C, Lazenby G, Schwebke J, Sobel JD
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S162-S168. doi: 10.1093/cid/ciab1057. PMID: 35416967
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027

Recent clinical studies

Etiology

Zhang H, Ding X, Hu X, Cai YX, Chen H, Sun C, Chen J, Li X, Zheng Z, Liao T, Zhao N, Zhong M, Fang R, Huang XF, Zheng J
BMC Public Health 2024 Jul 11;24(1):1858. doi: 10.1186/s12889-024-19078-5. PMID: 38992645Free PMC Article
Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, Manson JE, Pan A, Chavarro JE
BMJ 2021 Mar 24;372:n530. doi: 10.1136/bmj.n530. PMID: 33762255Free PMC Article
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M
BMJ 2000 Jun 24;320(7251):1708-12. doi: 10.1136/bmj.320.7251.1708. PMID: 10864550Free PMC Article
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Diagnosis

Yao Y, Ye Y, Chen J, Zhang M, Cai X, Zheng C
Am J Reprod Immunol 2024 May;91(5):e13859. doi: 10.1111/aji.13859. PMID: 38722063
Manning S, Kuhn D
Emerg Med Clin North Am 2023 May;41(2):295-305. doi: 10.1016/j.emc.2022.12.003. PMID: 37024165
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Apgar BS, Churgay CA
Prim Care 1993 Sep;20(3):621-7. PMID: 8378454
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Therapy

McLindon LA, James G, Beckmann MM, Bertolone J, Mahomed K, Vane M, Baker T, Gleed M, Grey S, Tettamanzi L, Mol BWJ, Li W
Hum Reprod 2023 Apr 3;38(4):560-568. doi: 10.1093/humrep/dead029. PMID: 36806843Free PMC Article
Jiang Y, Wang L, Shen H, Wang B, Wu J, Hu K, Wang Y, Ma B, Zhang X
Fertil Steril 2023 Apr;119(4):597-605. Epub 2022 Dec 24 doi: 10.1016/j.fertnstert.2022.12.035. PMID: 36574915
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ
Cochrane Database Syst Rev 2020 Aug 27;8(8):CD007807. doi: 10.1002/14651858.CD007807.pub4. PMID: 32851663Free PMC Article
Rooney KL, Domar AD
Dialogues Clin Neurosci 2018 Mar;20(1):41-47. doi: 10.31887/DCNS.2018.20.1/klrooney. PMID: 29946210Free PMC Article

Prognosis

Lawrence ER, Klein TJ, Beyuo TK
Obstet Gynecol Clin North Am 2022 Dec;49(4):713-733. doi: 10.1016/j.ogc.2022.07.001. PMID: 36328676
Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, Manson JE, Pan A, Chavarro JE
BMJ 2021 Mar 24;372:n530. doi: 10.1136/bmj.n530. PMID: 33762255Free PMC Article
Phillips J, Millum J
Bioethics 2015 Jul;29(6):413-23. Epub 2014 Nov 14 doi: 10.1111/bioe.12120. PMID: 25395144Free PMC Article
Holmes MM, Resnick HS, Kilpatrick DG, Best CL
Am J Obstet Gynecol 1996 Aug;175(2):320-4; discussion 324-5. doi: 10.1016/s0002-9378(96)70141-2. PMID: 8765248
BENSON RC
Calif Med 1950 Jun;72(6):442-6. PMID: 15414445Free PMC Article

Clinical prediction guides

He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Li LJ, Du R, Loy SL, Chong YS, Chan JKY, Wong TY, Eriksson JG, Huang Z, Zhang C
Fertil Steril 2022 Oct;118(4):748-757. Epub 2022 Aug 16 doi: 10.1016/j.fertnstert.2022.06.033. PMID: 35981917
Kalantari N, Gorgani-Firouzjaee T, Moulana Z, Chehrazi M, Ghaffari S
Microb Pathog 2021 Sep;158:105070. Epub 2021 Jun 26 doi: 10.1016/j.micpath.2021.105070. PMID: 34186117
Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766
Houghton DE, Moll S
Vasc Med 2017 Dec;22(6):545-550. Epub 2017 Nov 5 doi: 10.1177/1358863X17737374. PMID: 29103369

Recent systematic reviews

Paulsen CP, Bandak E, Edemann-Callesen H, Juhl CB, Händel MN
Int J Environ Res Public Health 2023 Jun 6;20(12) doi: 10.3390/ijerph20126069. PMID: 37372656Free PMC Article
Desaunay P, Eude LG, Dreyfus M, Alexandre C, Fedrizzi S, Alexandre J, Uguz F, Guénolé F
Paediatr Drugs 2023 May;25(3):247-265. Epub 2023 Feb 28 doi: 10.1007/s40272-023-00561-2. PMID: 36853497
Zhao QY, Li QH, Fu YY, Ren CE, Jiang AF, Meng YH
Front Immunol 2022;13:994888. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.994888. PMID: 36569856Free PMC Article
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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